ID:JUN_HUMAN DESCRIPTION: RecName: Full=Transcription factor AP-1; AltName: Full=Activator protein 1; Short=AP1; AltName: Full=Proto-oncogene c-Jun; AltName: Full=V-jun avian sarcoma virus 17 oncogene homolog; AltName: Full=p39; FUNCTION: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. SUBUNIT: Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3. INTERACTION: Q06481:APLP2; NbExp=3; IntAct=EBI-852823, EBI-79306; P05067:APP; NbExp=2; IntAct=EBI-852823, EBI-77613; P15336:ATF2; NbExp=4; IntAct=EBI-852823, EBI-1170906; Q8IWZ6:BBS7; NbExp=3; IntAct=EBI-852823, EBI-1806001; O43889:CREB3; NbExp=4; IntAct=EBI-852823, EBI-625002; P14921:ETS1; NbExp=3; IntAct=EBI-852823, EBI-913209; P01100:FOS; NbExp=6; IntAct=EBI-852823, EBI-852851; P07900:HSP90AA1; NbExp=2; IntAct=EBI-852823, EBI-296047; Q8WQG9:jnk-1 (xeno); NbExp=3; IntAct=EBI-852823, EBI-321822; P52292:KPNA2; NbExp=2; IntAct=EBI-852823, EBI-349938; P45983:MAPK8; NbExp=2; IntAct=EBI-852823, EBI-286483; P45983-1:MAPK8; NbExp=2; IntAct=EBI-852823, EBI-288687; Q9UPY8:MAPRE3; NbExp=3; IntAct=EBI-852823, EBI-726739; Q00987:MDM2; NbExp=3; IntAct=EBI-852823, EBI-389668; P48634:PRRC2A; NbExp=2; IntAct=EBI-852823, EBI-347545; Q9NRL3:STRN4; NbExp=3; IntAct=EBI-852823, EBI-717245; Q99986:VRK1; NbExp=4; IntAct=EBI-852823, EBI-1769146; SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity. PTM: Acetylated at Lys-271 by EP300. SIMILARITY: Belongs to the bZIP family. Jun subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/JUNID151.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/jun/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05412
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003690 double-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003713 transcription coactivator activity GO:0003723 RNA binding GO:0005096 GTPase activator activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0019899 enzyme binding GO:0031625 ubiquitin protein ligase binding GO:0033613 activating transcription factor binding GO:0035497 cAMP response element binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046982 protein heterodimerization activity GO:0070412 R-SMAD binding GO:0071837 HMG box domain binding
Biological Process: GO:0001525 angiogenesis GO:0001774 microglial cell activation GO:0001836 release of cytochrome c from mitochondria GO:0001889 liver development GO:0001938 positive regulation of endothelial cell proliferation GO:0003151 outflow tract morphogenesis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007265 Ras protein signal transduction GO:0007568 aging GO:0007612 learning GO:0007623 circadian rhythm GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0009314 response to radiation GO:0009612 response to mechanical stimulus GO:0009987 cellular process GO:0010033 response to organic substance GO:0010634 positive regulation of epithelial cell migration GO:0014070 response to organic cyclic compound GO:0030224 monocyte differentiation GO:0031103 axon regeneration GO:0031953 negative regulation of protein autophosphorylation GO:0032496 response to lipopolysaccharide GO:0032870 cellular response to hormone stimulus GO:0034097 response to cytokine GO:0034614 cellular response to reactive oxygen species GO:0035026 leading edge cell differentiation GO:0035994 response to muscle stretch GO:0038095 Fc-epsilon receptor signaling pathway GO:0042127 regulation of cell proliferation GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043392 negative regulation of DNA binding GO:0043524 negative regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043547 positive regulation of GTPase activity GO:0043922 negative regulation by host of viral transcription GO:0043923 positive regulation by host of viral transcription GO:0045597 positive regulation of cell differentiation GO:0045657 positive regulation of monocyte differentiation GO:0045740 positive regulation of DNA replication GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048146 positive regulation of fibroblast proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051365 cellular response to potassium ion starvation GO:0051591 response to cAMP GO:0051726 regulation of cell cycle GO:0051899 membrane depolarization GO:0060395 SMAD protein signal transduction GO:0061029 eyelid development in camera-type eye GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071276 cellular response to cadmium ion GO:0071277 cellular response to calcium ion GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1904707 positive regulation of vascular smooth muscle cell proliferation GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:2000144 positive regulation of DNA-templated transcription, initiation
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Common Gene Haplotype Alleles 
