Human Gene JUNB (ENST00000302754.6_4) from GENCODE V47lift37
  Description: JunB proto-oncogene, AP-1 transcription factor subunit (from RefSeq NM_002229.3)
Gencode Transcript: ENST00000302754.6_4
Gencode Gene: ENSG00000171223.6_7
Transcript (Including UTRs)
   Position: hg19 chr19:12,902,300-12,904,129 Size: 1,830 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr19:12,902,586-12,903,629 Size: 1,044 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:12,902,300-12,904,129)mRNA (may differ from genome)Protein (347 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: JUNB
Diseases sorted by gene-association score: anaplastic large cell lymphoma (5), fumarate hydratase deficiency (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 578.34 RPKM in Fallopian Tube
Total median expression: 7412.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -133.80286-0.468 Picture PostScript Text
3' UTR -171.50500-0.343 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR008917 - Euk_TF_DNA-bd
IPR005643 - JNK
IPR002112 - Leuzip_Jun

Pfam Domains:
PF00170 - bZIP transcription factor
PF03131 - bZIP Maf transcription factor
PF03957 - Jun-like transcription factor
PF07716 - Basic region leucine zipper

SCOP Domains:
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain

ModBase Predicted Comparative 3D Structure on Q5U079
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Biological Process:
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0009987 cellular process
GO:0030316 osteoclast differentiation
GO:0033687 osteoblast proliferation
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046697 decidualization
GO:0051726 regulation of cell cycle
GO:0060136 embryonic process involved in female pregnancy
GO:0060716 labyrinthine layer blood vessel development
GO:0071277 cellular response to calcium ion

Cellular Component:
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  DQ650707 - Homo sapiens JUNB mRNA, 5' UTR.
AK222532 - Homo sapiens mRNA for jun B proto-oncogene variant, clone: adSH01561.
AK313737 - Homo sapiens cDNA, FLJ94337, Homo sapiens jun B proto-oncogene (JUNB), mRNA.
BC110372 - Homo sapiens cDNA clone IMAGE:5547587.
BC004250 - Homo sapiens jun B proto-oncogene, mRNA (cDNA clone MGC:10557 IMAGE:3621911), complete cds.
BC009465 - Homo sapiens jun B proto-oncogene, mRNA (cDNA clone MGC:16048 IMAGE:3611163), complete cds.
BC009466 - Homo sapiens jun B proto-oncogene, mRNA (cDNA clone MGC:16052 IMAGE:3611749), complete cds.
JD383168 - Sequence 364192 from Patent EP1572962.
X51345 - Human jun-B mRNA for JUN-B protein.
JD200378 - Sequence 181402 from Patent EP1572962.
JD459010 - Sequence 440034 from Patent EP1572962.
JD200608 - Sequence 181632 from Patent EP1572962.
JD391615 - Sequence 372639 from Patent EP1572962.
CU678638 - Synthetic construct Homo sapiens gateway clone IMAGE:100019047 5' read JUNB mRNA.
AB464600 - Synthetic construct DNA, clone: pF1KB9619, Homo sapiens JUNB gene for jun B proto-oncogene, without stop codon, in Flexi system.
BT019760 - Homo sapiens jun B proto-oncogene mRNA, complete cds.
DQ893021 - Synthetic construct clone IMAGE:100005651; FLH191742.01X; RZPDo839G0677D jun B proto-oncogene (JUNB) gene, encodes complete protein.
DQ896266 - Synthetic construct Homo sapiens clone IMAGE:100010726; FLH191738.01L; RZPDo839G0667D jun B proto-oncogene (JUNB) gene, encodes complete protein.
KJ891495 - Synthetic construct Homo sapiens clone ccsbBroadEn_00889 JUNB gene, encodes complete protein.
KJ891496 - Synthetic construct Homo sapiens clone ccsbBroadEn_00890 JUNB gene, encodes complete protein.
CQ873714 - Sequence 133 from Patent WO2004076622.
DD413551 - Regulation of Mammalian Cells.
JD252215 - Sequence 233239 from Patent EP1572962.
JD177177 - Sequence 158201 from Patent EP1572962.
JD217419 - Sequence 198443 from Patent EP1572962.
JD130362 - Sequence 111386 from Patent EP1572962.
JD093312 - Sequence 74336 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000302754.1, ENST00000302754.2, ENST00000302754.3, ENST00000302754.4, ENST00000302754.5, hCG_172481 , JUNB , NM_002229, Q5U079, Q5U079_HUMAN, uc317ncl.1, uc317ncl.2
UCSC ID: ENST00000302754.6_4
RefSeq Accession: NM_002229.3
Protein: Q5U079

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.