ID:KAT2A_HUMAN DESCRIPTION: RecName: Full=Histone acetyltransferase KAT2A; EC=2.3.1.48; AltName: Full=General control of amino acid synthesis protein 5-like 2; AltName: Full=Histone acetyltransferase GCN5; Short=HsGCN5; AltName: Full=Lysine acetyltransferase 2A; AltName: Full=STAF97; FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. SUBUNIT: Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP. Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with and acetylates HIV-1 Tat. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with CSRP2BP, MBIP and WDR5. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in all tissues tested, with most abundant expression in ovary. SIMILARITY: Belongs to the GCN5 family. SIMILARITY: Contains 1 bromo domain. SIMILARITY: Contains 1 N-acetyltransferase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92830
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001701 in utero embryonic development GO:0001756 somitogenesis GO:0001816 cytokine production GO:0001843 neural tube closure GO:0006338 chromatin remodeling GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007399 nervous system development GO:0007507 heart development GO:0007616 long-term memory GO:0008283 cell proliferation GO:0014070 response to organic cyclic compound GO:0016032 viral process GO:0016573 histone acetylation GO:0016578 histone deubiquitination GO:0016579 protein deubiquitination GO:0018393 internal peptidyl-lysine acetylation GO:0021537 telencephalon development GO:0022037 metencephalon development GO:0030901 midbrain development GO:0031346 positive regulation of cell projection organization GO:0031647 regulation of protein stability GO:0031667 response to nutrient levels GO:0035066 positive regulation of histone acetylation GO:0035264 multicellular organism growth GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter GO:0043966 histone H3 acetylation GO:0043983 histone H4-K12 acetylation GO:0044154 histone H3-K14 acetylation GO:0045589 regulation of regulatory T cell differentiation GO:0045815 positive regulation of gene expression, epigenetic GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046600 negative regulation of centriole replication GO:0048167 regulation of synaptic plasticity GO:0048312 intracellular distribution of mitochondria GO:0050863 regulation of T cell activation GO:0055007 cardiac muscle cell differentiation GO:0060173 limb development GO:0071356 cellular response to tumor necrosis factor GO:0071929 alpha-tubulin acetylation GO:1990090 cellular response to nerve growth factor stimulus GO:2000679 positive regulation of transcription regulatory region DNA binding
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
