ID:KTNA1_HUMAN DESCRIPTION: RecName: Full=Katanin p60 ATPase-containing subunit A1; Short=Katanin p60 subunit A1; EC=3.6.4.3; AltName: Full=p60 katanin; FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity). CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. ENZYME REGULATION: ATPase activity is stimulated by microtubules, which promote homooligomerization (By similarity). ATP dependent microtubule severing is stimulated by interaction with KATNB1. SUBUNIT: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules (By similarity). Interacts with KATNB1, which may serve as a targeting subunit. Interacts with dynein and NDEL1 (By similarity). Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. DOMAIN: The N-terminus is sufficient for interaction with microtubules. However, high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization (By similarity). PTM: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation. PTM: Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted to proteasomal degradation. SIMILARITY: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00004 - ATPase family associated with various cellular activities (AAA) PF05496 - Holliday junction DNA helicase RuvB P-loop domain PF07724 - AAA domain (Cdc48 subfamily) PF09336 - Vps4 C terminal oligomerisation domain PF17862 - AAA+ lid domain
SCOP Domains: 48452 - TPR-like 116846 - MIT domain 52540 - P-loop containing nucleoside triphosphate hydrolases 53795 - PEP carboxykinase-like
ModBase Predicted Comparative 3D Structure on O75449
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
