Human Gene KBTBD7 (ENST00000379483.4_6) from GENCODE V47lift37
  Description: kelch repeat and BTB domain containing 7 (from RefSeq NM_032138.7)
Gencode Transcript: ENST00000379483.4_6
Gencode Gene: ENSG00000120696.9_8
Transcript (Including UTRs)
   Position: hg19 chr13:41,763,970-41,768,705 Size: 4,736 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr13:41,766,339-41,768,393 Size: 2,055 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:41,763,970-41,768,705)mRNA (may differ from genome)Protein (684 aa)
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-  Comments and Description Text from UniProtKB
  ID: KBTB7_HUMAN
DESCRIPTION: RecName: Full=Kelch repeat and BTB domain-containing protein 7;
INTERACTION: O95166:GABARAP; NbExp=2; IntAct=EBI-473695, EBI-712001; Q9H0R8:GABARAPL1; NbExp=3; IntAct=EBI-473695, EBI-746969; P60520:GABARAPL2; NbExp=2; IntAct=EBI-473695, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=3; IntAct=EBI-473695, EBI-373144; Q9BXW4:MAP1LC3C; NbExp=2; IntAct=EBI-473695, EBI-2603996;
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 5 Kelch repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.33 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 100.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -152.30312-0.488 Picture PostScript Text
3' UTR -513.202369-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR017096 - Kelch-like_gigaxonin
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1

Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07707 - BTB And C-terminal Kelch

SCOP Domains:
117281 - Kelch motif
50952 - Soluble quinoprotein glucose dehydrogenase
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q8WVZ9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0008150 biological_process
GO:0016567 protein ubiquitination
GO:0043687 post-translational protein modification

Cellular Component:
GO:0005575 cellular_component
GO:0005829 cytosol
GO:0031463 Cul3-RING ubiquitin ligase complex


-  Descriptions from all associated GenBank mRNAs
  LP895282 - Sequence 146 from Patent EP3253886.
AL136782 - Homo sapiens mRNA; cDNA DKFZp434E2318 (from clone DKFZp434E2318).
AK091344 - Homo sapiens cDNA FLJ34025 fis, clone FCBBF2003336, weakly similar to RING CANAL PROTEIN.
AX746923 - Sequence 448 from Patent EP1308459.
BC022033 - Homo sapiens kelch repeat and BTB (POZ) domain containing 7, mRNA (cDNA clone MGC:26978 IMAGE:4825536), complete cds.
FJ150424 - Homo sapiens kelch repeat and BTB POZ-domain containing 7 (KBTBD7) mRNA, complete cds.
JD541483 - Sequence 522507 from Patent EP1572962.
AK299614 - Homo sapiens cDNA FLJ51290 complete cds, highly similar to Kelch repeat and BTB domain-containing protein 7.
JD288667 - Sequence 269691 from Patent EP1572962.
JD504107 - Sequence 485131 from Patent EP1572962.
CR533558 - Homo sapiens full open reading frame cDNA clone RZPDo834H0521D for gene KBTBD7, kelch repeat and BTB (POZ) domain containing 7; complete cds, incl. stopcodon.
AK315589 - Homo sapiens cDNA, FLJ96667.
KJ894932 - Synthetic construct Homo sapiens clone ccsbBroadEn_04326 KBTBD7 gene, encodes complete protein.
DQ890838 - Synthetic construct clone IMAGE:100003468; FLH166358.01X; RZPDo839F1186D kelch repeat and BTB (POZ) domain containing 7 (KBTBD7) gene, encodes complete protein.
DQ893994 - Synthetic construct Homo sapiens clone IMAGE:100008454; FLH166354.01L; RZPDo839F1185D kelch repeat and BTB (POZ) domain containing 7 (KBTBD7) gene, encodes complete protein.
AB464601 - Synthetic construct DNA, clone: pF1KB9621, Homo sapiens KBTBD7 gene for kelch repeat and BTB (POZ) domain containing 7, without stop codon, in Flexi system.
AM393035 - Synthetic construct Homo sapiens clone IMAGE:100001695 for hypothetical protein (KBTBD7 gene).
AM393575 - Synthetic construct Homo sapiens clone IMAGE:100001693 for hypothetical protein (KBTBD7 gene).
CU692470 - Synthetic construct Homo sapiens gateway clone IMAGE:100020011 5' read KBTBD7 mRNA.
JD547258 - Sequence 528282 from Patent EP1572962.
JD120076 - Sequence 101100 from Patent EP1572962.
JD156252 - Sequence 137276 from Patent EP1572962.
JD427033 - Sequence 408057 from Patent EP1572962.
JD336355 - Sequence 317379 from Patent EP1572962.
JD336354 - Sequence 317378 from Patent EP1572962.
JD492560 - Sequence 473584 from Patent EP1572962.
JD201902 - Sequence 182926 from Patent EP1572962.
JD407105 - Sequence 388129 from Patent EP1572962.
JD173471 - Sequence 154495 from Patent EP1572962.
JD478356 - Sequence 459380 from Patent EP1572962.
JD203591 - Sequence 184615 from Patent EP1572962.
JD217532 - Sequence 198556 from Patent EP1572962.
JD487780 - Sequence 468804 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WVZ9 (Reactome details) participates in the following event(s):

R-HSA-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1
R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-597592 Post-translational protein modification
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-5683057 MAPK family signaling cascades
R-HSA-392499 Metabolism of proteins
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B5TZ86, ENST00000379483.1, ENST00000379483.2, ENST00000379483.3, KBTB7_HUMAN, KBTBD7 , NM_032138, Q5T6Y7, Q8NB99, Q8WVZ9, Q9H0I6, uc318ozr.1, uc318ozr.2
UCSC ID: ENST00000379483.4_6
RefSeq Accession: NM_032138.7
Protein: Q8WVZ9 (aka KBTB7_HUMAN or KBT7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.