ID:KCNH8_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily H member 8; AltName: Full=ELK1; Short=hElk1; AltName: Full=Ether-a-go-go-like potassium channel 3; Short=ELK channel 3; Short=ELK3; AltName: Full=Voltage-gated potassium channel subunit Kv12.1; FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Primarily expressed in the nervous system. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. SIMILARITY: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily. SIMILARITY: Contains 1 cyclic nucleotide-binding domain. SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. SIMILARITY: Contains 1 PAS (PER-ARNT-SIM) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96L42
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000160 phosphorelay signal transduction system GO:0006811 ion transport GO:0006813 potassium ion transport GO:0023014 signal transduction by protein phosphorylation GO:0034765 regulation of ion transmembrane transport GO:0042391 regulation of membrane potential GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
