Human Gene KCNJ4 (ENST00000303592.3_6) from GENCODE V47lift37
  Description: potassium inwardly rectifying channel subfamily J member 4, transcript variant 1 (from RefSeq NM_152868.3)
Gencode Transcript: ENST00000303592.3_6
Gencode Gene: ENSG00000168135.4_8
Transcript (Including UTRs)
   Position: hg19 chr22:38,822,332-38,851,205 Size: 28,874 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr22:38,822,800-38,824,137 Size: 1,338 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:38,822,332-38,851,205)mRNA (may differ from genome)Protein (445 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q58F07_HUMAN
DESCRIPTION: SubName: Full=KCNJ4 protein; Flags: Fragment;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the inward rectifier-type potassium channel family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KCNJ4
Diseases sorted by gene-association score: andersen syndrome (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.15 RPKM in Brain - Cortex
Total median expression: 311.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -129.90259-0.502 Picture PostScript Text
3' UTR -197.00468-0.421 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014756 - Ig_E-set
IPR016449 - K_chnl_inward-rec_Kir
IPR003273 - K_chnl_inward-rec_Kir2.3
IPR013518 - K_chnl_inward-rec_Kir_cyto

Pfam Domains:
PF01007 - Inward rectifier potassium channel transmembrane domain
PF17655 - Inward rectifier potassium channel C-terminal domain

SCOP Domains:
81296 - E set domains
81324 - Voltage-gated potassium channels

ModBase Predicted Comparative 3D Structure on Q58F07
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005242 inward rectifier potassium channel activity
GO:0005244 voltage-gated ion channel activity

Biological Process:
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  S72503 - HRK1=inward rectifier potassium channel [human, hippocampus, mRNA, 1913 nt].
U07364 - Human inwardly rectifying potassium channel mRNA, complete cds.
JD292856 - Sequence 273880 from Patent EP1572962.
JD052472 - Sequence 33496 from Patent EP1572962.
BC113506 - Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 4, mRNA (cDNA clone MGC:142066 IMAGE:8322558), complete cds.
BC113508 - Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 4, mRNA (cDNA clone MGC:142068 IMAGE:8322560), complete cds.
U24056 - Human inward rectifier K+ channel protein (hirk2) mRNA, complete cds.
JD388667 - Sequence 369691 from Patent EP1572962.
JD321211 - Sequence 302235 from Patent EP1572962.
JD174699 - Sequence 155723 from Patent EP1572962.
CR456507 - Homo sapiens KCNJ4 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.KCNJ4).
JD177780 - Sequence 158804 from Patent EP1572962.
JD121333 - Sequence 102357 from Patent EP1572962.
JD354105 - Sequence 335129 from Patent EP1572962.
JD404769 - Sequence 385793 from Patent EP1572962.
CU013106 - Homo sapiens KCNJ4, mRNA (cDNA clone IMAGE:100000364), complete cds, with stop codon, in Gateway system.
AB463188 - Synthetic construct DNA, clone: pF1KB8448, Homo sapiens KCNJ4 gene for potassium inwardly-rectifying channel, subfamily J, member 4, without stop codon, in Flexi system.
CU013394 - Homo sapiens KCNJ4, mRNA (cDNA clone IMAGE:100000268), complete cds, without stop codon, in Gateway system.
BC032562 - Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 4, mRNA (cDNA clone IMAGE:5578996), partial cds.
BC039618 - Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 4, mRNA (cDNA clone IMAGE:5770067).
JD470225 - Sequence 451249 from Patent EP1572962.
JD406179 - Sequence 387203 from Patent EP1572962.
JD280668 - Sequence 261692 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000303592.1, ENST00000303592.2, KCNJ4 , NM_152868, Q58F07, Q58F07_HUMAN, uc317ngn.1, uc317ngn.2
UCSC ID: ENST00000303592.3_6
RefSeq Accession: NM_152868.3
Protein: Q58F07

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.