ID:KCMB1_HUMAN DESCRIPTION: RecName: Full=Calcium-activated potassium channel subunit beta-1; AltName: Full=BK channel subunit beta-1; Short=BKbeta; Short=BKbeta1; Short=Hbeta1; AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta-1; Short=Calcium-activated potassium channel subunit beta; AltName: Full=Charybdotoxin receptor subunit beta-1; AltName: Full=K(VCA)beta-1; AltName: Full=Maxi K channel subunit beta-1; AltName: Full=Slo-beta-1; Short=Slo-beta; FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum. PTM: N-glycosylated. POLYMORPHISM: Genetic variation in KCNMB1 can influence the severity of diastolic hypertension. SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16558
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005513 detection of calcium ion GO:0006811 ion transport GO:0006813 potassium ion transport GO:0007268 chemical synaptic transmission GO:0007568 aging GO:0051592 response to calcium ion GO:0071361 cellular response to ethanol GO:0071456 cellular response to hypoxia GO:0071805 potassium ion transmembrane transport GO:1901381 positive regulation of potassium ion transmembrane transport GO:1903413 cellular response to bile acid
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
