ID:KCNN4_HUMAN DESCRIPTION: RecName: Full=Intermediate conductance calcium-activated potassium channel protein 4; Short=SK4; Short=SKCa 4; Short=SKCa4; AltName: Full=IKCa1; Short=IK1; AltName: Full=KCa3.1; AltName: Full=KCa4; AltName: Full=Putative Gardos channel; FUNCTION: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. SUBUNIT: Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in non-excitable tissues. INDUCTION: Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells. PTM: Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel. SIMILARITY: Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15554
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005267 potassium channel activity GO:0005515 protein binding GO:0005516 calmodulin binding GO:0015269 calcium-activated potassium channel activity GO:0016286 small conductance calcium-activated potassium channel activity GO:0019903 protein phosphatase binding
Biological Process: GO:0002376 immune system process GO:0006811 ion transport GO:0006813 potassium ion transport GO:0006816 calcium ion transport GO:0006884 cell volume homeostasis GO:0006952 defense response GO:0030322 stabilization of membrane potential GO:0045332 phospholipid translocation GO:0046541 saliva secretion GO:0050714 positive regulation of protein secretion GO:0050862 positive regulation of T cell receptor signaling pathway GO:0071805 potassium ion transmembrane transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
