ID:KDM4C_HUMAN DESCRIPTION: RecName: Full=Lysine-specific demethylase 4C; EC=1.14.11.-; AltName: Full=Gene amplified in squamous cell carcinoma 1 protein; Short=GASC-1 protein; AltName: Full=JmjC domain-containing histone demethylation protein 3C; AltName: Full=Jumonji domain-containing protein 2C; FUNCTION: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. COFACTOR: Binds 1 Fe(2+) ion per subunit. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Overexpressed in several esophageal squamous cell carcinomas (ESCs). DOMAIN: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity). SIMILARITY: Belongs to the JHDM3 histone demethylase family. SIMILARITY: Contains 1 JmjC domain. SIMILARITY: Contains 1 JmjN domain. SIMILARITY: Contains 2 PHD-type zinc fingers. SIMILARITY: Contains 2 Tudor domains. SEQUENCE CAUTION: Sequence=BAA34500.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI39608.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GASC1ID432.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H3R0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
