Human Gene RUBCNL (ENST00000378784.8_7) from GENCODE V47lift37
  Description: rubicon like autophagy enhancer, transcript variant 4 (from RefSeq NM_001286763.3)
Gencode Transcript: ENST00000378784.8_7
Gencode Gene: ENSG00000102445.20_17
Transcript (Including UTRs)
   Position: hg19 chr13:46,917,099-46,961,368 Size: 44,270 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr13:46,917,520-46,952,088 Size: 34,569 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:46,917,099-46,961,368)mRNA (may differ from genome)Protein (595 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K226L_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein KIAA0226-like;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.93 RPKM in Spleen
Total median expression: 83.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.10152-0.395 Picture PostScript Text
3' UTR -96.70421-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025258 - DUF4206

Pfam Domains:
PF13901 - Putative zinc-RING and/or ribbon

SCOP Domains:
48695 - Multiheme cytochromes

ModBase Predicted Comparative 3D Structure on Q9H714
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Descriptions from all associated GenBank mRNAs
  BC004495 - Homo sapiens chromosome 13 open reading frame 18, mRNA (cDNA clone IMAGE:3830267), partial cds.
BX641126 - Homo sapiens mRNA; cDNA DKFZp667G1115 (from clone DKFZp667G1115).
BC021097 - Homo sapiens chromosome 13 open reading frame 18, mRNA (cDNA clone IMAGE:4878849).
BC032311 - Homo sapiens chromosome 13 open reading frame 18, mRNA (cDNA clone IMAGE:5212065).
BC043488 - Homo sapiens chromosome 13 open reading frame 18, mRNA (cDNA clone MGC:49852 IMAGE:5205680), complete cds.
AK025215 - Homo sapiens cDNA: FLJ21562 fis, clone COL06420.
AK125750 - Homo sapiens cDNA FLJ43762 fis, clone TESTI2048465.
AK125950 - Homo sapiens cDNA FLJ43962 fis, clone TESTI4016822, highly similar to Protein phosphatase inhibitor 2.
AK300183 - Homo sapiens cDNA FLJ57196 complete cds.
AK307854 - Homo sapiens cDNA, FLJ97802.
AK293034 - Homo sapiens cDNA FLJ75517 complete cds.
AK093073 - Homo sapiens cDNA FLJ35754 fis, clone TESTI2004649, weakly similar to Homo sapiens B2 gene.
AX747903 - Sequence 1428 from Patent EP1308459.
KJ903285 - Synthetic construct Homo sapiens clone ccsbBroadEn_12679 KIAA0226L gene, encodes complete protein.
JD417388 - Sequence 398412 from Patent EP1572962.
JD314662 - Sequence 295686 from Patent EP1572962.
JD295603 - Sequence 276627 from Patent EP1572962.
JD563042 - Sequence 544066 from Patent EP1572962.
JD199760 - Sequence 180784 from Patent EP1572962.
AK310264 - Homo sapiens cDNA, FLJ17306.
KJ903286 - Synthetic construct Homo sapiens clone ccsbBroadEn_12680 KIAA0226L gene, encodes complete protein.
CU692164 - Synthetic construct Homo sapiens gateway clone IMAGE:100021463 5' read C13orf18 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: A8KAG9, A8XR19, B3KS87, C13orf18 , ENST00000378784.1, ENST00000378784.2, ENST00000378784.3, ENST00000378784.4, ENST00000378784.5, ENST00000378784.6, ENST00000378784.7, KIAA0226L , NM_001286763, PACER_HUMAN, Q5W051, Q5W053, Q6PJ74, Q6PK94, Q86XH7, Q8N5J6, Q9H714, RUBCNL , uc318onl.1, uc318onl.2
UCSC ID: ENST00000378784.8_7
RefSeq Accession: NM_001286763.3
Protein: Q9H714 (aka K226L_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.