Human Gene PRORP (ENST00000250377.11_5) from GENCODE V47lift37
  Description: protein only RNase P catalytic subunit, transcript variant 2 (from RefSeq NM_001256678.2)
Gencode Transcript: ENST00000250377.11_5
Gencode Gene: ENSG00000100890.16_14
Transcript (Including UTRs)
   Position: hg19 chr14:35,591,770-35,746,820 Size: 155,051 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr14:35,592,452-35,742,772 Size: 150,321 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:35,591,770-35,746,820)mRNA (may differ from genome)Protein (567 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MRRP3_HUMAN
DESCRIPTION: RecName: Full=Mitochondrial ribonuclease P protein 3; Short=Mitochondrial RNase P protein 3; Flags: Precursor;
FUNCTION: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends.
SUBUNIT: Interacts with MRPP1/TRMT10C and MRPP2/HSD17B10.
SUBCELLULAR LOCATION: Mitochondrion.
SEQUENCE CAUTION: Sequence=BAA20845.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -88.40366-0.242 Picture PostScript Text
3' UTR -1359.404048-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026318 - MRPP3

Pfam Domains:
PF01535 - PPR repeat
PF16953 - Protein-only RNase P

ModBase Predicted Comparative 3D Structure on O15091
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004518 nuclease activity
GO:0004526 ribonuclease P activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0001682 tRNA 5'-leader removal
GO:0008033 tRNA processing
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0090646 mitochondrial tRNA processing
GO:0097745 mitochondrial tRNA 5'-end processing

Cellular Component:
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030678 mitochondrial ribonuclease P complex


-  Descriptions from all associated GenBank mRNAs
  AK301931 - Homo sapiens cDNA FLJ57649 complete cds.
BC050339 - Homo sapiens cDNA clone IMAGE:5260943, **** WARNING: chimeric clone ****.
BC044580 - Homo sapiens KIAA0391, mRNA (cDNA clone MGC:57169 IMAGE:4822711), complete cds.
BC001542 - Homo sapiens cDNA clone IMAGE:3456976, containing frame-shift errors.
AK304066 - Homo sapiens cDNA FLJ61536 complete cds.
BC032221 - Homo sapiens KIAA0391, mRNA (cDNA clone MGC:36741 IMAGE:5206545), complete cds.
AB002389 - Homo sapiens mRNA for KIAA0391 gene.
BX161394 - human full-length cDNA clone CS0DC011YE22 of Neuroblastoma of Homo sapiens (human).
BX161487 - human full-length cDNA clone CS0DJ005YK17 of T cells (Jurkat cell line) of Homo sapiens (human).
AK303508 - Homo sapiens cDNA FLJ57464 complete cds.
AB385323 - Synthetic construct DNA, clone: pF1KA0391, Homo sapiens KIAA0391 gene for KIAA0391 protein, complete cds, without stop codon, in Flexi system.
KJ906005 - Synthetic construct Homo sapiens clone ccsbBroadEn_15675 KIAA0391 gene, encodes complete protein.
KJ898073 - Synthetic construct Homo sapiens clone ccsbBroadEn_07467 KIAA0391 gene, encodes complete protein.
JD065716 - Sequence 46740 from Patent EP1572962.
JD074242 - Sequence 55266 from Patent EP1572962.
JD345499 - Sequence 326523 from Patent EP1572962.
JD510633 - Sequence 491657 from Patent EP1572962.
CU689302 - Synthetic construct Homo sapiens gateway clone IMAGE:100017417 5' read KIAA0391 mRNA.
CU692206 - Synthetic construct Homo sapiens gateway clone IMAGE:100020991 5' read KIAA0391 mRNA.
JD236949 - Sequence 217973 from Patent EP1572962.
JD254403 - Sequence 235427 from Patent EP1572962.
JD043907 - Sequence 24931 from Patent EP1572962.
JD513852 - Sequence 494876 from Patent EP1572962.
JD311781 - Sequence 292805 from Patent EP1572962.
JD535097 - Sequence 516121 from Patent EP1572962.
JD103538 - Sequence 84562 from Patent EP1572962.
JD429151 - Sequence 410175 from Patent EP1572962.
JD081730 - Sequence 62754 from Patent EP1572962.
JD394194 - Sequence 375218 from Patent EP1572962.
JD245081 - Sequence 226105 from Patent EP1572962.
JD131253 - Sequence 112277 from Patent EP1572962.
JD509366 - Sequence 490390 from Patent EP1572962.
JD268804 - Sequence 249828 from Patent EP1572962.
JD043703 - Sequence 24727 from Patent EP1572962.
JD302314 - Sequence 283338 from Patent EP1572962.
JD205424 - Sequence 186448 from Patent EP1572962.
JD175505 - Sequence 156529 from Patent EP1572962.
JD471943 - Sequence 452967 from Patent EP1572962.
JD279099 - Sequence 260123 from Patent EP1572962.
JD543098 - Sequence 524122 from Patent EP1572962.
JD478434 - Sequence 459458 from Patent EP1572962.
JD478435 - Sequence 459459 from Patent EP1572962.
JD463662 - Sequence 444686 from Patent EP1572962.
JD147999 - Sequence 129023 from Patent EP1572962.
JD516233 - Sequence 497257 from Patent EP1572962.
JD516234 - Sequence 497258 from Patent EP1572962.
JD370199 - Sequence 351223 from Patent EP1572962.
JD176874 - Sequence 157898 from Patent EP1572962.
JD167608 - Sequence 148632 from Patent EP1572962.
JD167609 - Sequence 148633 from Patent EP1572962.
JD300941 - Sequence 281965 from Patent EP1572962.
JD481184 - Sequence 462208 from Patent EP1572962.
JD179276 - Sequence 160300 from Patent EP1572962.
JD188714 - Sequence 169738 from Patent EP1572962.
JD096008 - Sequence 77032 from Patent EP1572962.
JD552122 - Sequence 533146 from Patent EP1572962.
JD411100 - Sequence 392124 from Patent EP1572962.
JD062120 - Sequence 43144 from Patent EP1572962.
JD560144 - Sequence 541168 from Patent EP1572962.
JD387927 - Sequence 368951 from Patent EP1572962.
JD322863 - Sequence 303887 from Patent EP1572962.
JD356170 - Sequence 337194 from Patent EP1572962.
JD112281 - Sequence 93305 from Patent EP1572962.
JD209823 - Sequence 190847 from Patent EP1572962.
JD097617 - Sequence 78641 from Patent EP1572962.
JD481177 - Sequence 462201 from Patent EP1572962.
JD277096 - Sequence 258120 from Patent EP1572962.
JD498193 - Sequence 479217 from Patent EP1572962.
JD430614 - Sequence 411638 from Patent EP1572962.
JD557661 - Sequence 538685 from Patent EP1572962.
JD455273 - Sequence 436297 from Patent EP1572962.
JD329042 - Sequence 310066 from Patent EP1572962.
JD130736 - Sequence 111760 from Patent EP1572962.
JD130737 - Sequence 111761 from Patent EP1572962.
JD343064 - Sequence 324088 from Patent EP1572962.
JD093278 - Sequence 74302 from Patent EP1572962.
JD314700 - Sequence 295724 from Patent EP1572962.
JD277899 - Sequence 258923 from Patent EP1572962.
JD490977 - Sequence 472001 from Patent EP1572962.
JD237374 - Sequence 218398 from Patent EP1572962.
JD358734 - Sequence 339758 from Patent EP1572962.
JD418235 - Sequence 399259 from Patent EP1572962.
JD288292 - Sequence 269316 from Patent EP1572962.
JD164280 - Sequence 145304 from Patent EP1572962.
JD299885 - Sequence 280909 from Patent EP1572962.
JD249237 - Sequence 230261 from Patent EP1572962.
JD352637 - Sequence 333661 from Patent EP1572962.
JD352640 - Sequence 333664 from Patent EP1572962.
JD352642 - Sequence 333666 from Patent EP1572962.
JD352643 - Sequence 333667 from Patent EP1572962.
JD067418 - Sequence 48442 from Patent EP1572962.
JD536853 - Sequence 517877 from Patent EP1572962.
JD132792 - Sequence 113816 from Patent EP1572962.
JD071707 - Sequence 52731 from Patent EP1572962.
JD242785 - Sequence 223809 from Patent EP1572962.
JD331137 - Sequence 312161 from Patent EP1572962.
JD441810 - Sequence 422834 from Patent EP1572962.
JD409367 - Sequence 390391 from Patent EP1572962.
JD119887 - Sequence 100911 from Patent EP1572962.
JD396355 - Sequence 377379 from Patent EP1572962.
JD142725 - Sequence 123749 from Patent EP1572962.
JD277530 - Sequence 258554 from Patent EP1572962.
JD317951 - Sequence 298975 from Patent EP1572962.
JD168113 - Sequence 149137 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O15091 (Reactome details) participates in the following event(s):

R-HSA-6787594 TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9
R-HSA-6787591 TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9
R-HSA-6785470 tRNA processing in the mitochondrion
R-HSA-8868766 rRNA processing in the mitochondrion
R-HSA-6787450 tRNA modification in the mitochondrion
R-HSA-72306 tRNA processing
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: B4DXD9, B4E0S8, B4E211, C4AM93, D3DS99, D3DSA1, ENST00000250377.1, ENST00000250377.10, ENST00000250377.2, ENST00000250377.3, ENST00000250377.4, ENST00000250377.5, ENST00000250377.6, ENST00000250377.7, ENST00000250377.8, ENST00000250377.9, KIAA0391, MRPP3 , MRPP3_HUMAN, NM_001256678, O15091, PRORP , Q86SZ4, Q86YB5, Q8N5L5, uc317fbl.1, uc317fbl.2
UCSC ID: ENST00000250377.11_5
RefSeq Accession: NM_001256678.2
Protein: O15091 (aka MRRP3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.