Human Gene KIF11 (ENST00000260731.5_4) from GENCODE V47lift37
  Description: kinesin family member 11 (from RefSeq NM_004523.4)
Gencode Transcript: ENST00000260731.5_4
Gencode Gene: ENSG00000138160.7_12
Transcript (Including UTRs)
   Position: hg19 chr10:94,352,887-94,415,152 Size: 62,266 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg19 chr10:94,353,133-94,413,553 Size: 60,421 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:94,352,887-94,415,152)mRNA (may differ from genome)Protein (1056 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KIF11_HUMAN
DESCRIPTION: RecName: Full=Kinesin-like protein KIF11; AltName: Full=Kinesin-like protein 1; AltName: Full=Kinesin-like spindle protein HKSP; AltName: Full=Kinesin-related motor protein Eg5; AltName: Full=Thyroid receptor-interacting protein 5; Short=TR-interacting protein 5; Short=TRIP-5;
FUNCTION: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
SUBUNIT: Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.
PTM: Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Phosphorylated upon DNA damage, probably by ATM or ATR.
PTM: A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.
DISEASE: Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:152950]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.
SIMILARITY: Belongs to the kinesin-like protein family. BimC subfamily.
SIMILARITY: Contains 1 kinesin-motor domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KIF11
Diseases sorted by gene-association score: microcephaly with or without chorioretinopathy, lymphedema, or mental retardation* (1350), congenital lymphedema (20), autosomal dominant microcephaly (18), lymphedema (16), exudative vitreoretinopathy (9), xeroderma pigmentosum, group f (8), invasive bladder transitional cell carcinoma (6), microcephaly (5), astigmatism (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.85 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 61.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -105.00246-0.427 Picture PostScript Text
3' UTR -369.001599-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025901 - Kinesin-assoc_MT-bd_dom
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom

Pfam Domains:
PF00225 - Kinesin motor domain
PF13931 - Kinesin-associated microtubule-binding
PF16796 - Microtubule binding

SCOP Domains:
48371 - ARM repeat
52540 - P-loop containing nucleoside triphosphate hydrolases
58113 - Apolipoprotein A-I

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1II6 - X-ray MuPIT 1Q0B - X-ray MuPIT 1X88 - X-ray MuPIT 1YRS - X-ray MuPIT 2FKY - X-ray MuPIT 2FL2 - X-ray MuPIT 2FL6 - X-ray MuPIT 2FME - X-ray MuPIT 2G1Q - X-ray MuPIT 2GM1 - X-ray MuPIT 2IEH - X-ray MuPIT 2PG2 - X-ray MuPIT 2Q2Y - X-ray MuPIT 2Q2Z - X-ray MuPIT 2UYI - X-ray MuPIT 2UYM - X-ray MuPIT 2WOG - X-ray MuPIT 2X2R - X-ray MuPIT 2X7C - X-ray MuPIT 2X7D - X-ray MuPIT 2X7E - X-ray MuPIT 2XAE - X-ray MuPIT 3CJO - X-ray MuPIT 3HQD - X-ray MuPIT 3K3B - X-ray MuPIT 3K5E - X-ray MuPIT 3KEN - X-ray MuPIT 3L9H - X-ray MuPIT 4AP0 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P52732
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
GO:0019901 protein kinase binding
GO:0044877 macromolecular complex binding

Biological Process:
GO:0000278 mitotic cell cycle
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007018 microtubule-based movement
GO:0007049 cell cycle
GO:0007051 spindle organization
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007100 mitotic centrosome separation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0046602 regulation of mitotic centrosome separation
GO:0051225 spindle assembly
GO:0051301 cell division
GO:0090307 mitotic spindle assembly

Cellular Component:
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0072686 mitotic spindle
GO:0005876 spindle microtubule


-  Descriptions from all associated GenBank mRNAs
  BC050421 - Homo sapiens kinesin family member 11, mRNA (cDNA clone IMAGE:6471737).
AK314258 - Homo sapiens cDNA, FLJ95005, highly similar to Homo sapiens kinesin family member 11 (KIF11), mRNA.
BC136474 - Homo sapiens kinesin family member 11, mRNA (cDNA clone MGC:168086 IMAGE:9020463), complete cds.
BC126211 - Homo sapiens kinesin family member 11, mRNA (cDNA clone MGC:161489 IMAGE:8991927), complete cds.
U37426 - Human kinesin-like spindle protein HKSP (HKSP) mRNA, complete cds.
X85137 - H.sapiens mRNA for kinesin-related protein.
BC050667 - Homo sapiens, clone IMAGE:6013224, mRNA.
JD174189 - Sequence 155213 from Patent EP1572962.
HV496035 - JP 2011518117-A/1263: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401552 - JP 2015177801-A/1263: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496019 - JP 2011518117-A/1247: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401536 - JP 2015177801-A/1247: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496037 - JP 2011518117-A/1265: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401554 - JP 2015177801-A/1265: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496015 - JP 2011518117-A/1243: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401532 - JP 2015177801-A/1243: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496022 - JP 2011518117-A/1250: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401539 - JP 2015177801-A/1250: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496023 - JP 2011518117-A/1251: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401540 - JP 2015177801-A/1251: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496025 - JP 2011518117-A/1253: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401542 - JP 2015177801-A/1253: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496024 - JP 2011518117-A/1252: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401541 - JP 2015177801-A/1252: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496026 - JP 2011518117-A/1254: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401543 - JP 2015177801-A/1254: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496027 - JP 2011518117-A/1255: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401544 - JP 2015177801-A/1255: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496033 - JP 2011518117-A/1261: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401550 - JP 2015177801-A/1261: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496028 - JP 2011518117-A/1256: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401545 - JP 2015177801-A/1256: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496018 - JP 2011518117-A/1246: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401535 - JP 2015177801-A/1246: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496031 - JP 2011518117-A/1259: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401548 - JP 2015177801-A/1259: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496017 - JP 2011518117-A/1245: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401534 - JP 2015177801-A/1245: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496036 - JP 2011518117-A/1264: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401553 - JP 2015177801-A/1264: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496034 - JP 2011518117-A/1262: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401551 - JP 2015177801-A/1262: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496021 - JP 2011518117-A/1249: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401538 - JP 2015177801-A/1249: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496032 - JP 2011518117-A/1260: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401549 - JP 2015177801-A/1260: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
AB208964 - Homo sapiens mRNA for kinesin family member 11 variant protein.
HV496030 - JP 2011518117-A/1258: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ401547 - JP 2015177801-A/1258: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
L40372 - Homo sapiens thyroid receptor interactor (TRIP5) mRNA, partial cds.
JD564395 - Sequence 545419 from Patent EP1572962.
JD558319 - Sequence 539343 from Patent EP1572962.
JD558320 - Sequence 539344 from Patent EP1572962.
JD540189 - Sequence 521213 from Patent EP1572962.
JD560096 - Sequence 541120 from Patent EP1572962.
JD356975 - Sequence 337999 from Patent EP1572962.
JD395749 - Sequence 376773 from Patent EP1572962.
JD217791 - Sequence 198815 from Patent EP1572962.
JD520606 - Sequence 501630 from Patent EP1572962.
JD144545 - Sequence 125569 from Patent EP1572962.
JD084352 - Sequence 65376 from Patent EP1572962.
JD247768 - Sequence 228792 from Patent EP1572962.
JD326810 - Sequence 307834 from Patent EP1572962.
JD430125 - Sequence 411149 from Patent EP1572962.
JD557297 - Sequence 538321 from Patent EP1572962.
JD529107 - Sequence 510131 from Patent EP1572962.
JD169179 - Sequence 150203 from Patent EP1572962.
JD169180 - Sequence 150204 from Patent EP1572962.
JD041215 - Sequence 22239 from Patent EP1572962.
JD320963 - Sequence 301987 from Patent EP1572962.
JD387940 - Sequence 368964 from Patent EP1572962.
JD387941 - Sequence 368965 from Patent EP1572962.
JD118022 - Sequence 99046 from Patent EP1572962.
JD292784 - Sequence 273808 from Patent EP1572962.
JD080893 - Sequence 61917 from Patent EP1572962.
JD177398 - Sequence 158422 from Patent EP1572962.
JD188571 - Sequence 169595 from Patent EP1572962.
JD303815 - Sequence 284839 from Patent EP1572962.
JD401939 - Sequence 382963 from Patent EP1572962.
JD060936 - Sequence 41960 from Patent EP1572962.
JD053502 - Sequence 34526 from Patent EP1572962.
JD330403 - Sequence 311427 from Patent EP1572962.
JD382197 - Sequence 363221 from Patent EP1572962.
JD328833 - Sequence 309857 from Patent EP1572962.
JD173149 - Sequence 154173 from Patent EP1572962.
JD283538 - Sequence 264562 from Patent EP1572962.
JD348490 - Sequence 329514 from Patent EP1572962.
JD196745 - Sequence 177769 from Patent EP1572962.
JD312991 - Sequence 294015 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P52732 (Reactome details) participates in the following event(s):

R-HSA-984606 Kinesin-5 is a homotetramer
R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-109582 Hemostasis
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-1280218 Adaptive Immune System
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-168256 Immune System
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: A0AV49, B2RMV3, EG5, ENST00000260731.1, ENST00000260731.2, ENST00000260731.3, ENST00000260731.4, KIF11_HUMAN, KNSL1, NM_004523, P52732, Q15716, Q5VWX0, TRIP5, uc317gln.1, uc317gln.2
UCSC ID: ENST00000260731.5_4
RefSeq Accession: NM_004523.4
Protein: P52732 (aka KIF11_HUMAN or KF11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.