ID:KI13A_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF13A; AltName: Full=Kinesin-like protein RBKIN; FUNCTION: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. SUBUNIT: Interacts with AP2B1 (By similarity). Interacts with ZFYVE26. Interacts with AP1G1 and AP1G2. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane (By similarity). Note=Recruited to the midbody during cytokinesis. TISSUE SPECIFICITY: Widely expressed, with highest levels in heart, brain and skeletal muscle. DEVELOPMENTAL STAGE: Expressed at very low level in most fetal tissues, but at higher levels in skeletal muscle and lung. SIMILARITY: Belongs to the kinesin-like protein family. SIMILARITY: Contains 1 FHA domain. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=CAI21670.1; Type=Erroneous gene model prediction; Sequence=CAI21671.1; Type=Erroneous gene model prediction; Sequence=CAI40947.1; Type=Erroneous gene model prediction; Sequence=CAI40948.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H1H9
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0007018 microtubule-based movement GO:0007049 cell cycle GO:0008333 endosome to lysosome transport GO:0015031 protein transport GO:0030705 cytoskeleton-dependent intracellular transport GO:0032438 melanosome organization GO:0032465 regulation of cytokinesis GO:0035459 cargo loading into vesicle GO:0043001 Golgi to plasma membrane protein transport GO:0051301 cell division GO:0072383 plus-end-directed vesicle transport along microtubule
LP896415 - Sequence 1279 from Patent EP3253886. AJ291579 - Homo sapiens mRNA for KINESIN-13A2 (KIN13A gene). AJ291578 - Homo sapiens mRNA for KINESIN-13A1 (KIN13A gene). AY014403 - Homo sapiens kinesin-like protein RBKIN1 (RBKIN) mRNA, complete cds, alternatively spliced. AY014404 - Homo sapiens kinesin-like protein RBKIN2 (RBKIN) mRNA, complete cds, alternatively spliced. BC127115 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150707 IMAGE:40125246), complete cds. BC127116 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150708 IMAGE:40125251), complete cds. BC001730 - Homo sapiens cDNA clone IMAGE:3353875, containing frame-shift errors. BC023613 - Homo sapiens cDNA clone IMAGE:4646849, containing frame-shift errors. BC062673 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone IMAGE:6654466), with apparent retained intron. AK130742 - Homo sapiens cDNA FLJ27232 fis, clone SYN06360. JD204951 - Sequence 185975 from Patent EP1572962. JD486786 - Sequence 467810 from Patent EP1572962. JD404219 - Sequence 385243 from Patent EP1572962. AK025303 - Homo sapiens cDNA: FLJ21650 fis, clone COL08516. AK225214 - Homo sapiens mRNA for kinesin family member 13A variant, clone: COL08516. JD336425 - Sequence 317449 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H1H9 (Reactome details) participates in the following event(s):
R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
