ID:KI26A_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF26A; FUNCTION: Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). SUBUNIT: Interacts with GRB2 (via SH2 domain) (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). SIMILARITY: Belongs to the kinesin-like protein family. KIF26 subfamily. SIMILARITY: Contains 1 kinesin-motor domain. CAUTION: In contrast to other kinesin-like proteins, residues required for ATPase activity are missing. SEQUENCE CAUTION: Sequence=AAH09415.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULI4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001560 regulation of cell growth by extracellular stimulus GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0009968 negative regulation of signal transduction GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0048484 enteric nervous system development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
