Human Gene KIF3C (ENST00000264712.8_7) from GENCODE V47lift37
  Description: kinesin family member 3C (from RefSeq NM_002254.8)
Gencode Transcript: ENST00000264712.8_7
Gencode Gene: ENSG00000084731.15_11
Transcript (Including UTRs)
   Position: hg19 chr2:26,149,467-26,205,366 Size: 55,900 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr2:26,151,847-26,204,786 Size: 52,940 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:26,149,467-26,205,366)mRNA (may differ from genome)Protein (793 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KIF3C_HUMAN
DESCRIPTION: RecName: Full=Kinesin-like protein KIF3C;
FUNCTION: Microtubule-based anterograde translocator for membranous organelles (By similarity).
SUBUNIT: Heterodimer of KIF3A and KIF3C (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable).
SIMILARITY: Belongs to the kinesin-like protein family. Kinesin II subfamily.
SIMILARITY: Contains 1 kinesin-motor domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 58.36 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 503.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -274.10580-0.473 Picture PostScript Text
3' UTR -744.002380-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom

Pfam Domains:
PF00225 - Kinesin motor domain
PF16796 - Microtubule binding

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3B6V - X-ray


ModBase Predicted Comparative 3D Structure on O14782
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity

Biological Process:
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007018 microtubule-based movement
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0035735 intraciliary transport involved in cilium assembly
GO:0072384 organelle transport along microtubule

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005929 cilium
GO:0097542 ciliary tip


-  Descriptions from all associated GenBank mRNAs
  LF384835 - JP 2014500723-A/192338: Polycomb-Associated Non-Coding RNAs.
BX571741 - Homo sapiens mRNA; cDNA DKFZp686G1646 (from clone DKFZp686G1646).
AF035621 - Homo sapiens kinesin-related protein (KIF3C) mRNA, complete cds.
JD201587 - Sequence 182611 from Patent EP1572962.
JD089051 - Sequence 70075 from Patent EP1572962.
AB290173 - Homo sapiens mRNA for KIF3C variant protein, complete cds.
JD422813 - Sequence 403837 from Patent EP1572962.
JD269181 - Sequence 250205 from Patent EP1572962.
BC130423 - Homo sapiens kinesin family member 3C, mRNA (cDNA clone MGC:163295 IMAGE:40146454), complete cds.
BC132783 - Homo sapiens kinesin family member 3C, mRNA (cDNA clone MGC:164414 IMAGE:40146805), complete cds.
BC144223 - Homo sapiens kinesin family member 3C, mRNA (cDNA clone MGC:177760 IMAGE:9052743), complete cds.
JD226077 - Sequence 207101 from Patent EP1572962.
JD417373 - Sequence 398397 from Patent EP1572962.
JD262791 - Sequence 243815 from Patent EP1572962.
JD367420 - Sequence 348444 from Patent EP1572962.
JD446193 - Sequence 427217 from Patent EP1572962.
JD414413 - Sequence 395437 from Patent EP1572962.
JD434377 - Sequence 415401 from Patent EP1572962.
JD294670 - Sequence 275694 from Patent EP1572962.
JD090829 - Sequence 71853 from Patent EP1572962.
AF018164 - Homo sapiens kinesin-like protein 3C (KIF3C) mRNA, complete cds.
BC092406 - Homo sapiens kinesin family member 3C, mRNA (cDNA clone MGC:102751 IMAGE:6504352), complete cds.
BC042486 - Homo sapiens kinesin family member 3C, mRNA (cDNA clone MGC:9147 IMAGE:3866587), complete cds.
JD299946 - Sequence 280970 from Patent EP1572962.
JD052449 - Sequence 33473 from Patent EP1572962.
JD091223 - Sequence 72247 from Patent EP1572962.
JD290103 - Sequence 271127 from Patent EP1572962.
JD065964 - Sequence 46988 from Patent EP1572962.
JD296775 - Sequence 277799 from Patent EP1572962.
JD248930 - Sequence 229954 from Patent EP1572962.
JD523308 - Sequence 504332 from Patent EP1572962.
JD137532 - Sequence 118556 from Patent EP1572962.
JD053076 - Sequence 34100 from Patent EP1572962.
BC018932 - Homo sapiens kinesin family member 3C, mRNA (cDNA clone IMAGE:4303936).
JD063598 - Sequence 44622 from Patent EP1572962.
JD123448 - Sequence 104472 from Patent EP1572962.
JD149058 - Sequence 130082 from Patent EP1572962.
JD051852 - Sequence 32876 from Patent EP1572962.
JD215614 - Sequence 196638 from Patent EP1572962.
JD060632 - Sequence 41656 from Patent EP1572962.
JD306791 - Sequence 287815 from Patent EP1572962.
JD366842 - Sequence 347866 from Patent EP1572962.
JD102783 - Sequence 83807 from Patent EP1572962.
JD547191 - Sequence 528215 from Patent EP1572962.
JD147674 - Sequence 128698 from Patent EP1572962.
JD248409 - Sequence 229433 from Patent EP1572962.
JD346332 - Sequence 327356 from Patent EP1572962.
JD140706 - Sequence 121730 from Patent EP1572962.
AK293738 - Homo sapiens cDNA FLJ53846 complete cds, highly similar to Kinesin-like protein KIF3C.
JD261412 - Sequence 242436 from Patent EP1572962.
JD423823 - Sequence 404847 from Patent EP1572962.
JD353638 - Sequence 334662 from Patent EP1572962.
JD282283 - Sequence 263307 from Patent EP1572962.
JD186978 - Sequence 168002 from Patent EP1572962.
AK315324 - Homo sapiens cDNA, FLJ96360.
AB384383 - Synthetic construct DNA, clone: pF1KSDB0057, Homo sapiens KIF3C gene for kinesin family member 3C, complete cds, without stop codon, in Flexi system.
KJ901041 - Synthetic construct Homo sapiens clone ccsbBroadEn_10435 KIF3C gene, encodes complete protein.
LF328687 - JP 2014500723-A/136190: Polycomb-Associated Non-Coding RNAs.
LF328686 - JP 2014500723-A/136189: Polycomb-Associated Non-Coding RNAs.
LF328682 - JP 2014500723-A/136185: Polycomb-Associated Non-Coding RNAs.
LF328681 - JP 2014500723-A/136184: Polycomb-Associated Non-Coding RNAs.
LF328680 - JP 2014500723-A/136183: Polycomb-Associated Non-Coding RNAs.
LF212476 - JP 2014500723-A/19979: Polycomb-Associated Non-Coding RNAs.
LF328679 - JP 2014500723-A/136182: Polycomb-Associated Non-Coding RNAs.
JD170681 - Sequence 151705 from Patent EP1572962.
JD135205 - Sequence 116229 from Patent EP1572962.
MA620412 - JP 2018138019-A/192338: Polycomb-Associated Non-Coding RNAs.
MA564264 - JP 2018138019-A/136190: Polycomb-Associated Non-Coding RNAs.
MA564263 - JP 2018138019-A/136189: Polycomb-Associated Non-Coding RNAs.
MA564259 - JP 2018138019-A/136185: Polycomb-Associated Non-Coding RNAs.
MA564258 - JP 2018138019-A/136184: Polycomb-Associated Non-Coding RNAs.
MA564257 - JP 2018138019-A/136183: Polycomb-Associated Non-Coding RNAs.
MA564256 - JP 2018138019-A/136182: Polycomb-Associated Non-Coding RNAs.
MA448053 - JP 2018138019-A/19979: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O14782 (Reactome details) participates in the following event(s):

R-HSA-984708 Kinesin-2 is a heterotrimer
R-HSA-983266 Kinesins bind microtubules
R-HSA-5625424 The retrograde IFT train dissociates
R-HSA-5624952 Assembly of the retrograde IFT train
R-HSA-5625421 The anterograde IFT train dissociates
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-5624949 Assembly of the anterograde IFT train
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-109582 Hemostasis
R-HSA-5620924 Intraflagellar transport
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-5617833 Cilium Assembly
R-HSA-1280218 Adaptive Immune System
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-168256 Immune System
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000264712.1, ENST00000264712.2, ENST00000264712.3, ENST00000264712.4, ENST00000264712.5, ENST00000264712.6, ENST00000264712.7, KIF3C_HUMAN, NM_002254, O14782, O43544, Q4ZG18, Q53SX5, Q562F7, uc317huv.1, uc317huv.2
UCSC ID: ENST00000264712.8_7
RefSeq Accession: NM_002254.8
Protein: O14782 (aka KIF3C_HUMAN or KF3C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.