ID:KIFC1_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIFC1; AltName: Full=Kinesin-like protein 2; AltName: Full=Kinesin-related protein HSET; FUNCTION: Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. SUBUNIT: Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Early endosome (By similarity). Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis (By similarity). MISCELLANEOUS: HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis. SIMILARITY: Belongs to the kinesin-like protein family. NCD subfamily. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=AAH00712.2; Type=Erroneous initiation; Sequence=AAH63567.1; Type=Erroneous initiation; Sequence=AAH73878.1; Type=Erroneous initiation; Sequence=AAH98438.1; Type=Erroneous initiation; Sequence=BAA03509.1; Type=Frameshift; Positions=223, 256;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BW19
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AJ010479 - Homo sapiens mRNA for kinesin-like protein 2. JD078472 - Sequence 59496 from Patent EP1572962. BC000712 - Homo sapiens kinesin family member C1, mRNA (cDNA clone IMAGE:3506669). BC073878 - Homo sapiens kinesin family member C1, mRNA (cDNA clone IMAGE:3914750). JD478379 - Sequence 459403 from Patent EP1572962. BC098438 - Homo sapiens kinesin family member C1, mRNA (cDNA clone IMAGE:3532250). AK297378 - Homo sapiens cDNA FLJ53841 complete cds, highly similar to Kinesin-like protein KIFC1. AK303239 - Homo sapiens cDNA FLJ54292 complete cds, highly similar to Kinesin-like protein KIFC1. BC063567 - Homo sapiens kinesin family member C1, mRNA (cDNA clone IMAGE:4178503). JD336837 - Sequence 317861 from Patent EP1572962. BC121041 - Homo sapiens kinesin family member C1, mRNA (cDNA clone MGC:149736 IMAGE:40117894), complete cds. BC121042 - Homo sapiens kinesin family member C1, mRNA (cDNA clone MGC:149737 IMAGE:40117899), complete cds. JD153879 - Sequence 134903 from Patent EP1572962. KJ904496 - Synthetic construct Homo sapiens clone ccsbBroadEn_13890 KIFC1-like gene, encodes complete protein. D14678 - Homo sapiens HSET mRNA for kinesin-related protein, partial cds. JD094816 - Sequence 75840 from Patent EP1572962. JD317849 - Sequence 298873 from Patent EP1572962. JD473127 - Sequence 454151 from Patent EP1572962. JD473109 - Sequence 454133 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BW19 (Reactome details) participates in the following event(s):
R-HSA-990478 Kinesin-14 is a dimer R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-983189 Kinesins R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-109582 Hemostasis R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
