Human Gene KIR2DL3 (ENST00000342376.4_4) from GENCODE V47lift37
  Description: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 (from RefSeq NM_015868.3)
Gencode Transcript: ENST00000342376.4_4
Gencode Gene: ENSG00000243772.8_8
Transcript (Including UTRs)
   Position: hg19 chr19:55,249,978-55,264,504 Size: 14,527 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr19:55,250,011-55,263,971 Size: 13,961 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:55,249,978-55,264,504)mRNA (may differ from genome)Protein (341 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KI2L3_HUMAN
DESCRIPTION: RecName: Full=Killer cell immunoglobulin-like receptor 2DL3; AltName: Full=CD158 antigen-like family member B2; AltName: Full=KIR-023GB; AltName: Full=Killer inhibitory receptor cl 2-3; AltName: Full=MHC class I NK cell receptor; AltName: Full=NKAT2a; AltName: Full=NKAT2b; AltName: Full=Natural killer-associated transcript 2; Short=NKAT-2; AltName: Full=p58 natural killer cell receptor clone CL-6; Short=p58 NK receptor CL-6; AltName: Full=p58.2 MHC class-I-specific NK receptor; AltName: CD_antigen=CD158b2; Flags: Precursor;
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
SUBUNIT: Interacts with ARRB2.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the immunoglobulin superfamily.
SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KIR2DL3
Diseases sorted by gene-association score: trachoma (22), hematopoietic stem cell transplantation (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.50 RPKM in Whole Blood
Total median expression: 4.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.6033-0.321 Picture PostScript Text
3' UTR -120.63533-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013151 - Immunoglobulin

Pfam Domains:
PF00047 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1B6U - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P43628
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003823 antigen binding
GO:0005515 protein binding
GO:0038023 signaling receptor activity

Biological Process:
GO:0006955 immune response
GO:0007165 signal transduction
GO:0050776 regulation of immune response

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF135557 - Homo sapiens p58 killer cell inhibitory receptor KIR-K36 (KIR-K36) mRNA, partial cds.
L41268 - Homo sapiens natural killer-associated transcript 2 (NKAT2) mRNA, complete cds.
LP896121 - Sequence 985 from Patent EP3253886.
BC050730 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3, mRNA (cDNA clone MGC:60369 IMAGE:5219336), complete cds.
U24074 - Human p58 natural killer cell receptor precursor mRNA, clone cl-6, complete cds.
U73395 - Human NK-receptor (KIR-023GB) mRNA, complete cds.
BC110613 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3, mRNA (cDNA clone MGC:129943 IMAGE:40031619), complete cds.
BC032422 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3, mRNA (cDNA clone MGC:39949 IMAGE:5220339), complete cds.
L76663 - Homo sapiens nkat2b mRNA, complete cds.
L76662 - Homo sapiens nkat2a mRNA, complete cds.
U50546 - Human natural killer-associated transcript 2a protein (NKAT2a-delta-Ig2) mRNA, complete cds.
DQ890622 - Synthetic construct clone IMAGE:100003252; FLH164426.01X; RZPDo839G02162D killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 (KIR2DL3) gene, encodes complete protein.
DQ893791 - Synthetic construct Homo sapiens clone IMAGE:100008251; FLH164422.01L; RZPDo839G02161D killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 (KIR2DL3) gene, encodes complete protein.
KJ897093 - Synthetic construct Homo sapiens clone ccsbBroadEn_06487 KIR2DL3 gene, encodes complete protein.
LS974079 - Homo sapiens mRNA for KIR2DL3 protein (KIR2DL3 gene), isolate 04, allele Del51bp_(ex6)_hKIR2DL3_00201.
LS974085 - Homo sapiens mRNA for KIR2DL3 protein (KIR2DL3 gene), isolate 04, 38, allele Del294bp_(ex5)_hKIR2DL3_00201.
LS974098 - Homo sapiens mRNA for KIR2DL3 protein (KIR2DL3 gene), isolate 10, 39, allele Del150bp_(3ss)_hKIR2DL3_00101.
LS974108 - Homo sapiens mRNA for KIR2DL3 protein (KIR2DL3 gene), isolate 04, 06, allele Del294bp_(3-5ss)_hKIR2DL3_00201.
LS974113 - Homo sapiens mRNA for KIR2DL3 protein (KIR2DL3 gene), isolate 00, 04, allele Ins78bp_(Cry)_hKIR2DL3_00101.
AF022048 - Homo sapiens natural killer cell inhibitory receptor KIR2DL3 variant mRNA, complete cds.
AY789057 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL3) mRNA, KIR2DL3*007 allele, complete cds.
FN552550 - Homo sapiens partial mRNA for killer Ig-like inhibitory receptor (KIR2DL3 gene).
AF285435 - Homo sapiens clone KIR2DL3v2 killer-cell Ig-like receptor mRNA, partial cds.
AF285433 - Homo sapiens clone KIR2DL2v1 killer-cell Ig-like receptor mRNA, partial cds.
JD022847 - Sequence 3871 from Patent EP1572962.
AF135565 - Homo sapiens p58 killer cell inhibitory receptor KIR-K7a mRNA, alternatively spliced, partial cds.
AF135566 - Homo sapiens p58 killer cell inhibitory receptor KIR-K7b mRNA, alternatively spliced, partial cds.
AF135567 - Homo sapiens p58 killer cell inhibitory receptor KIR-K7c mRNA, alternatively spliced, partial cds.
AF135561 - Homo sapiens p58 killer cell inhibitory receptor KIR-K65 (KIR-K65) mRNA, partial cds.
U96190 - Homo sapiens p58 NK cell inhibitory receptor NKR-K7 mRNA, partial cds.
JD036258 - Sequence 17282 from Patent EP1572962.
JD098050 - Sequence 79074 from Patent EP1572962.
JD269876 - Sequence 250900 from Patent EP1572962.
JD353407 - Sequence 334431 from Patent EP1572962.
JD525272 - Sequence 506296 from Patent EP1572962.
JD480912 - Sequence 461936 from Patent EP1572962.
JD291661 - Sequence 272685 from Patent EP1572962.
JD533385 - Sequence 514409 from Patent EP1572962.
JD132047 - Sequence 113071 from Patent EP1572962.
JD132046 - Sequence 113070 from Patent EP1572962.
JD148398 - Sequence 129422 from Patent EP1572962.
JD273309 - Sequence 254333 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P43628 (Reactome details) participates in the following event(s):

R-HSA-198958 KIR2DL2/3 interacting with HLA-C group 1 (Cw4)
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CD158B2, ENST00000342376.1, ENST00000342376.2, ENST00000342376.3, KI2L3_HUMAN, KIR2DL3 , KIRCL23, NKAT2, NM_015868, O43472, P43628, P78402, Q14944, Q14945, Q9UM51, Q9UQ70, uc317wie.1, uc317wie.2
UCSC ID: ENST00000342376.4_4
RefSeq Accession: NM_015868.3
Protein: P43628 (aka KI2L3_HUMAN or K2L3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.