Human Gene KIR3DL2 (ENST00000326321.7_8) from GENCODE V47lift37
  Description: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2, transcript variant 1 (from RefSeq NM_006737.4)
Gencode Transcript: ENST00000326321.7_8
Gencode Gene: ENSG00000240403.6_10
Transcript (Including UTRs)
   Position: hg19 chr19:55,361,898-55,378,662 Size: 16,765 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr19:55,361,931-55,378,186 Size: 16,256 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:55,361,898-55,378,662)mRNA (may differ from genome)Protein (455 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KI3L2_HUMAN
DESCRIPTION: RecName: Full=Killer cell immunoglobulin-like receptor 3DL2; AltName: Full=CD158 antigen-like family member K; AltName: Full=MHC class I NK cell receptor; AltName: Full=Natural killer-associated transcript 4; Short=NKAT-4; AltName: Full=p70 natural killer cell receptor clone CL-5; Short=p70 NK receptor CL-5; AltName: CD_antigen=CD158k; Flags: Precursor;
FUNCTION: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the immunoglobulin superfamily.
SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KIR3DL2
Diseases sorted by gene-association score: mild pre-eclampsia (6), sezary's disease (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.48 RPKM in Whole Blood
Total median expression: 2.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.0033-0.333 Picture PostScript Text
3' UTR -95.30476-0.200 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub

Pfam Domains:
PF00047 - Immunoglobulin domain
PF13895 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on P43630
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006968 cellular defense response
GO:0050776 regulation of immune response

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LT963640 - Homo sapiens mRNA for KIR2DL protein (KIR2DL1/3DL2 gene), isolate 01, 04, allele KIR2DL1/3DL2.
AY366253 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1/2V) mRNA, KIR3DL1/2V*c allele, complete cds.
AY366255 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1/2V) mRNA, KIR3DL1/2V*d allele, complete cds.
AY366254 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1/2V) mRNA, KIR3DL1/2V*b allele, complete cds.
AY059417 - Homo sapiens killer-cell immunoglobulin-like receptor KIR3DL1/2v mRNA, partial cds.
AF135559 - Homo sapiens p58 killer cell inhibitory receptor KIR-K61 (KIR-K61) mRNA, partial cds.
AF135561 - Homo sapiens p58 killer cell inhibitory receptor KIR-K65 (KIR-K65) mRNA, partial cds.
AF135562 - Homo sapiens p58 killer cell inhibitory receptor KIR-K78 (KIR-K78) mRNA, partial cds.
AF262967 - Homo sapiens killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) mRNA, KIR3DL2*00801 allele, complete cds.
AF263617 - Homo sapiens killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) mRNA, KIR3DL2*00901 allele, complete cds.
X93595 - H.sapiens mRNA for NK receptor (clone 17.1C).
BC105678 - Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2, mRNA (cDNA clone MGC:125320 IMAGE:40004817), complete cds.
BC107951 - Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2, mRNA (cDNA clone MGC:125321 IMAGE:40004820), complete cds.
L41270 - Homo sapiens NK-associated transcript 4 (NKAT4) mRNA, complete cds.
AY366256 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL2) mRNA, KIR3DL2*013 allele, complete cds.
L76666 - Homo sapiens NKAT4b mRNA, complete cds.
L76665 - Homo sapiens Nkat4a mRNA, complete cds.
KJ891513 - Synthetic construct Homo sapiens clone ccsbBroadEn_00907 KIR3DL2 gene, encodes complete protein.
U30272 - Human KIR (cl-5) NK receptor precursor protein mRNA, complete cds.
AJ276125 - Homo sapiens mRNA for inhibitory NK receptor (kir3d gene).
X94373 - H.sapiens mRNA for HLA class I inhibitory NK receptor (1.1).
AY789068 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL2) mRNA, KIR3DL2*00902 allele, complete cds.
AY789070 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL2) mRNA, KIR3DL2*015 allele, complete cds.
EF582384 - Homo sapiens killer cell immunoglobulin-like receptor KIR3DL2 (KIR3DL2) mRNA, KIR3DL2*022 allele, complete cds.
LS974083 - Homo sapiens mRNA for KIR3DL2 protein (KIR3DL2 gene), isolate 82, 85, allele Del51bp_(ex6)_hKIR3DL2_00701.
LS974090 - Homo sapiens mRNA for KIR3DL2 protein (KIR3DL2 gene), isolate 39, allele Del105bp_(ex7)_hKIR3DL2_008.
LS974094 - Homo sapiens mRNA for KIR3DL2 protein (KIR3DL2 gene), isolate 39, allele Del156bp_(ex6+7)_hKIR3DL2_008.
LS974102 - Homo sapiens mRNA for KIR3DL2 protein (KIR3DL2 gene), isolate 02, 04, allele Ins129bp_(5ss)_hKIR3DL2_00201.
LS974109 - Homo sapiens mRNA for KIR3DL2 protein (KIR3DL2 gene), isolate 04, allele Del294_(3-5ss)_hKIR3DL2_00201.
LT934502 - Homo sapiens mRNA for KIR3DL2 protein (KIR3DL2 gene), isolate human, allele KIR3DL2-011:01.
X94374 - H.sapiens mRNA for HLA class I inhibitory NK receptor (AMC5).
AY789067 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL2) mRNA, KIR3DL2*002 allele, complete cds.
X93596 - H.sapiens mRNA for HLA specific NK receptor.
AY789069 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL2) mRNA, KIR3DL2*014 allele, partial cds.
AY789071 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL2) mRNA, KIR3DL2*016 allele, partial cds.
AF208683 - Homo sapiens clone 1 p70 killer cell inhibitory receptor mRNA, partial cds.
AF208684 - Homo sapiens clone 6 p70 killer cell inhibitory receptor mRNA, partial cds.
AF208685 - Homo sapiens clone 21 p70 killer cell inhibitory receptor mRNA, partial cds.
AF208686 - Homo sapiens clone 23 p70 killer cell inhibitory receptor mRNA, partial cds.
AF208687 - Homo sapiens clone 25 p70 killer cell inhibitory receptor mRNA, partial cds.
AF208690 - Homo sapiens clone 24 p70 killer cell inhibitory receptor mRNA, partial cds.
DQ256504 - Homo sapiens KIR3DL2 mRNA, partial cds.
AY059418 - Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL2) mRNA, KIR3DL2*010 allele, partial cds.
AY059419 - Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL2) mRNA, KIR3DL2*011 allele, partial cds.
AY059420 - Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL2) mRNA, KIR3DL2*012 allele, partial cds.
AF262965 - Homo sapiens killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) mRNA, KIR3DL2*00701 allele, partial cds.
AF262966 - Homo sapiens killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) mRNA, KIR3DL2*00601 allele, partial cds.
AF135558 - Homo sapiens p58 killer cell inhibitory receptor KIR-K39 (KIR-K39) mRNA, partial cds.
JD353404 - Sequence 334428 from Patent EP1572962.
JD353407 - Sequence 334431 from Patent EP1572962.
JD228897 - Sequence 209921 from Patent EP1572962.
JD354283 - Sequence 335307 from Patent EP1572962.
JD237441 - Sequence 218465 from Patent EP1572962.
JD078718 - Sequence 59742 from Patent EP1572962.
JD565291 - Sequence 546315 from Patent EP1572962.
JD510504 - Sequence 491528 from Patent EP1572962.
JD259180 - Sequence 240204 from Patent EP1572962.
JD291661 - Sequence 272685 from Patent EP1572962.
JD533385 - Sequence 514409 from Patent EP1572962.
JD132046 - Sequence 113070 from Patent EP1572962.
JD132047 - Sequence 113071 from Patent EP1572962.
JD148398 - Sequence 129422 from Patent EP1572962.
JD273310 - Sequence 254334 from Patent EP1572962.
JD428054 - Sequence 409078 from Patent EP1572962.
JD087251 - Sequence 68275 from Patent EP1572962.
JD163033 - Sequence 144057 from Patent EP1572962.
MK460225 - Homo sapiens isolate C167 KIR3DL2 mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P43630 (Reactome details) participates in the following event(s):

R-HSA-199576 KIR3DL2 interacting with HLA-A3
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CD158K, ENST00000326321.1, ENST00000326321.2, ENST00000326321.3, ENST00000326321.4, ENST00000326321.5, ENST00000326321.6, KI3L2_HUMAN, KIR3DL2 , NKAT4, NM_006737, P43630, Q13238, Q14947, Q14948, Q92684, Q95366, Q95367, Q95368, uc317sas.1, uc317sas.2
UCSC ID: ENST00000326321.7_8
RefSeq Accession: NM_006737.4
Protein: P43630 (aka KI3L2_HUMAN or K3L2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.