Human Gene KLC1 (ENST00000334553.11_4) from GENCODE V47lift37
  Description: kinesin light chain 1, transcript variant 9 (from RefSeq NM_001394837.1)
Gencode Transcript: ENST00000334553.11_4
Gencode Gene: ENSG00000126214.22_17
Transcript (Including UTRs)
   Position: hg19 chr14:104,095,548-104,167,881 Size: 72,334 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr14:104,120,902-104,167,063 Size: 46,162 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:104,095,548-104,167,881)mRNA (may differ from genome)Protein (639 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: KLC1_HUMAN
DESCRIPTION: RecName: Full=Kinesin light chain 1; Short=KLC 1;
FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
SUBUNIT: Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9 (By similarity). Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable).
TISSUE SPECIFICITY: Found in a variety of tissues. Mostly abundant in brain and spine.
PTM: Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631.
SIMILARITY: Belongs to the kinesin light chain family.
SIMILARITY: Contains 6 TPR repeats.
CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
SEQUENCE CAUTION: Sequence=AAA16576.1; Type=Erroneous initiation; Sequence=AAF72543.1; Type=Erroneous initiation; Sequence=AAO62549.1; Type=Erroneous initiation; Sequence=DAA01265.1; Type=Erroneous initiation; Sequence=DAA01266.1; Type=Erroneous initiation; Sequence=DAA01268.1; Type=Erroneous initiation; Sequence=DAA01291.1; Type=Erroneous initiation; Sequence=DAA01292.1; Type=Erroneous initiation; Sequence=DAA01295.1; Type=Erroneous initiation; Sequence=DAA01296.1; Type=Erroneous initiation; Sequence=DAA01297.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KLC1
Diseases sorted by gene-association score: medulloblastoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.00 RPKM in Nerve - Tibial
Total median expression: 967.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -166.50285-0.584 Picture PostScript Text
3' UTR -141.70345-0.411 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002151 - Kinesin_light
IPR015792 - Kinesin_light_repeat
IPR015390 - Rabaptin_Rab5-bd_dom
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF00515 - Tetratricopeptide repeat
PF01535 - PPR repeat
PF13176 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
PF13374 - Tetratricopeptide repeat
PF13424 - Tetratricopeptide repeat
PF13432 - Tetratricopeptide repeat
PF17874 - MalT-like TPR region

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48445 - 14-3-3 protein
48452 - TPR-like
116846 - MIT domain
58050 - N-terminal coiled coil domain from apc
57997 - Tropomyosin

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3NF1 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q07866
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0005515 protein binding

Biological Process:
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007018 microtubule-based movement
GO:0016032 viral process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0035617 stress granule disassembly

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  AK299527 - Homo sapiens cDNA FLJ55519 complete cds, highly similar to Kinesin light chain 1.
AK294508 - Homo sapiens cDNA FLJ61233 complete cds, highly similar to Kinesin light chain 1.
BC008881 - Homo sapiens kinesin light chain 1, mRNA (cDNA clone MGC:15245 IMAGE:4301579), complete cds.
L04733 - Homo sapiens kinesin light chain mRNA, complete cds.
AF527736 - Homo sapiens medulloblastoma antigen MU-MB-2.50 mRNA, partial cds.
AY180164 - Homo sapiens kinesin light chain 1C (KNS2) mRNA, complete cds.
JD026390 - Sequence 7414 from Patent EP1572962.
JD423274 - Sequence 404298 from Patent EP1572962.
JD508673 - Sequence 489697 from Patent EP1572962.
JD060225 - Sequence 41249 from Patent EP1572962.
JD459798 - Sequence 440822 from Patent EP1572962.
DQ893256 - Synthetic construct clone IMAGE:100005886; FLH195673.01X; RZPDo839F01152D kinesin 2 (KNS2) gene, encodes complete protein.
DQ896585 - Synthetic construct Homo sapiens clone IMAGE:100011045; FLH195669.01L; RZPDo839F01151D kinesin 2 (KNS2) gene, encodes complete protein.
KJ891518 - Synthetic construct Homo sapiens clone ccsbBroadEn_00912 KLC1 gene, encodes complete protein.
AB385087 - Synthetic construct DNA, clone: pF1KB5346, Homo sapiens KLC1 gene for kinesin light chain 1, complete cds, without stop codon, in Flexi system.
JD510804 - Sequence 491828 from Patent EP1572962.
AB451431 - Homo sapiens KLC1 mRNA for kinesin light chain 1, partial cds, clone: FLJ08153AAAF.
AB451299 - Homo sapiens KLC1 mRNA for kinesin light chain 1, complete cds, clone: FLJ08153AAAN.
JD025691 - Sequence 6715 from Patent EP1572962.
JD033140 - Sequence 14164 from Patent EP1572962.
JD025287 - Sequence 6311 from Patent EP1572962.
JD030993 - Sequence 12017 from Patent EP1572962.
AB781674 - Homo sapiens KLC1-ALK mRNA for KLC1-ALK fusion protein, partial cds.
AY180163 - Homo sapiens kinesin light chain 1S (KNS2) mRNA, partial cds.
AY244715 - Homo sapiens kinesin light chain 1B (KNS2) mRNA, partial cds; alternatively spliced.
AY180166 - Homo sapiens kinesin light chain 1N (KNS2) mRNA, partial cds.
AY180170 - Homo sapiens kinesin light chain 1J (KNS2) mRNA, partial cds.
AY180167 - Homo sapiens kinesin light chain 1P (KNS2) mRNA, partial cds.
AY180169 - Homo sapiens kinesin light chain 1R (KNS2) mRNA, partial cds.
AY180168 - Homo sapiens kinesin light chain 1G (KNS2) mRNA, partial cds.
AY180165 - Homo sapiens kinesin light chain 1K (KNS2) mRNA, partial cds.
AK125022 - Homo sapiens cDNA FLJ43032 fis, clone BRTHA3001221.
AK024714 - Homo sapiens cDNA: FLJ21061 fis, clone CAS01010.
AL133587 - Homo sapiens mRNA; cDNA DKFZp434I139 (from clone DKFZp434I139).
JD125523 - Sequence 106547 from Patent EP1572962.
JD470036 - Sequence 451060 from Patent EP1572962.
JD228725 - Sequence 209749 from Patent EP1572962.
JD532740 - Sequence 513764 from Patent EP1572962.
JD090605 - Sequence 71629 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q07866 (Reactome details) participates in the following event(s):

R-HSA-983194 Kinesin-1 is a heterotetramer
R-HSA-5672083 KTN1 binds Kinesin-1
R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-983189 Kinesins
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-195258 RHO GTPase Effectors
R-HSA-109582 Hemostasis
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-194315 Signaling by Rho GTPases
R-HSA-1280218 Adaptive Immune System
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: A6NF62, ENST00000334553.1, ENST00000334553.10, ENST00000334553.2, ENST00000334553.3, ENST00000334553.4, ENST00000334553.5, ENST00000334553.6, ENST00000334553.7, ENST00000334553.8, ENST00000334553.9, F8VTM4, KLC, KLC1_HUMAN, KNS2, NM_001394837, Q07866, Q7RTM2, Q7RTM3, Q7RTM5, Q7RTP9, Q7RTQ3, Q7RTQ5, Q7RTQ6, Q86SF5, Q86TF5, Q86V74, Q86V75, Q86V76, Q86V77, Q86V78, Q86V79, Q96H62, uc317tzw.1, uc317tzw.2
UCSC ID: ENST00000334553.11_4
RefSeq Accession: NM_001394837.1
Protein: Q07866 (aka KLC1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.