Human Gene KLF12 (ENST00000703967.1_4) from GENCODE V47lift37

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Description: Kruppel like factor 12, transcript variant 12 (from RefSeq NM_001400153.1)
Gencode Transcript: ENST00000703967.1_4
Gencode Gene: ENSG00000118922.19_12
Transcript (Including UTRs)
Position: hg19 chr13:74,260,226-74,708,541 Size: 448,316 Total Exon Count: 8 Strand: -
Coding Region
Position: hg19 chr13:74,269,627-74,569,159 Size: 299,533 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr13:74,260,226-74,708,541)			mRNA (may differ from genome)		Protein (402 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
Malacards	MGI	PubMed	UniProtKB	Wikipedia

Comments and Description Text from UniProtKB


	ID: KLF12_HUMAN DESCRIPTION: RecName: Full=Krueppel-like factor 12; AltName: Full=Transcriptional repressor AP-2rep; FUNCTION: Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family. SIMILARITY: Contains 3 C2H2-type zinc fingers.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: KLF12 Diseases sorted by gene-association score: wegener granulomatosis (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D016572 Cyclosporine C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone D016604 Aflatoxin B1 D002251 Carbon Tetrachloride D020111 Chlorodiphenyl (54% Chlorine) D003375 Coumestrol D004052 Diethylnitrosamine D008558 Melphalan D008628 Mercury more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-194.90	464	-0.420	Picture	PostScript	Text
3' UTR	-2379.20	9401	-0.253	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

SCOP Domains:
49599 - TRAF domain-like
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q9Y4X4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0046872 metal ion binding Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	AF330041 - Homo sapiens AP-2 repressor mRNA, complete cds. BC019680 - Homo sapiens Kruppel-like factor 12, mRNA (cDNA clone MGC:24862 IMAGE:4942405), complete cds. AK291397 - Homo sapiens cDNA FLJ75938 complete cds, highly similar to Homo sapiens Kruppel-like factor 12 (KLF12), transcript variant 1, mRNA. HF546212 - Homo sapiens mRNA for Kruppel-like factor 12, splice variant 1 (KLF12 gene). AJ243274 - Homo sapiens mRNA for AP-2rep protein (ap-2rep gene). DQ891773 - Synthetic construct clone IMAGE:100004403; FLH179801.01X; RZPDo839C11132D Kruppel-like factor 12 (KLF12) gene, encodes complete protein. DQ894957 - Synthetic construct Homo sapiens clone IMAGE:100009417; FLH179797.01L; RZPDo839C11131D Kruppel-like factor 12 (KLF12) gene, encodes complete protein. KJ898399 - Synthetic construct Homo sapiens clone ccsbBroadEn_07793 KLF12 gene, encodes complete protein. AB384998 - Synthetic construct DNA, clone: pF1KB4907, Homo sapiens KLF12 gene for krueppel-like factor 12, complete cds, without stop codon, in Flexi system. AF161471 - Homo sapiens HSPC122 mRNA, complete cds. AF113122 - Homo sapiens AP-2rep transcription factor mRNA, complete cds. CU676462 - Synthetic construct Homo sapiens gateway clone IMAGE:100019244 5' read KLF12 mRNA. AY584194 - Homo sapiens clone C4 isolate JA Trypanosoma cruzi infected macrophage transcript J mRNA, partial sequence. AY584195 - Homo sapiens clone C4 isolate JB Trypanosoma cruzi infected macrophage LINE-1 element mRNA, partial sequence. JD297541 - Sequence 278565 from Patent EP1572962. JD315933 - Sequence 296957 from Patent EP1572962. JD450601 - Sequence 431625 from Patent EP1572962. JD534180 - Sequence 515204 from Patent EP1572962. JD224793 - Sequence 205817 from Patent EP1572962. JD222096 - Sequence 203120 from Patent EP1572962. JD304138 - Sequence 285162 from Patent EP1572962. AK126412 - Homo sapiens cDNA FLJ44448 fis, clone UTERU2021917. AK094419 - Homo sapiens cDNA FLJ37100 fis, clone BRACE2019147. JD298581 - Sequence 279605 from Patent EP1572962. JD046639 - Sequence 27663 from Patent EP1572962. JD066450 - Sequence 47474 from Patent EP1572962. JD375305 - Sequence 356329 from Patent EP1572962. JD298305 - Sequence 279329 from Patent EP1572962. JD504140 - Sequence 485164 from Patent EP1572962. JD309440 - Sequence 290464 from Patent EP1572962. JD543840 - Sequence 524864 from Patent EP1572962. JD553451 - Sequence 534475 from Patent EP1572962. JD364095 - Sequence 345119 from Patent EP1572962. JD295550 - Sequence 276574 from Patent EP1572962. JD510569 - Sequence 491593 from Patent EP1572962. JD281907 - Sequence 262931 from Patent EP1572962. JD253915 - Sequence 234939 from Patent EP1572962. JD045433 - Sequence 26457 from Patent EP1572962. JD348870 - Sequence 329894 from Patent EP1572962. JD166278 - Sequence 147302 from Patent EP1572962. JD437908 - Sequence 418932 from Patent EP1572962. JD250414 - Sequence 231438 from Patent EP1572962. JD292826 - Sequence 273850 from Patent EP1572962. JD345001 - Sequence 326025 from Patent EP1572962. JD198892 - Sequence 179916 from Patent EP1572962. JD313719 - Sequence 294743 from Patent EP1572962. JD240931 - Sequence 221955 from Patent EP1572962. JD509438 - Sequence 490462 from Patent EP1572962. JD162610 - Sequence 143634 from Patent EP1572962. JD549974 - Sequence 530998 from Patent EP1572962. JD146409 - Sequence 127433 from Patent EP1572962. JD307803 - Sequence 288827 from Patent EP1572962. AK096503 - Homo sapiens cDNA FLJ39184 fis, clone OCBBF2004385. JD501942 - Sequence 482966 from Patent EP1572962. JD534363 - Sequence 515387 from Patent EP1572962. JD122994 - Sequence 104018 from Patent EP1572962. JD190515 - Sequence 171539 from Patent EP1572962. JD063958 - Sequence 44982 from Patent EP1572962. JD438760 - Sequence 419784 from Patent EP1572962. JD552573 - Sequence 533597 from Patent EP1572962. JD353359 - Sequence 334383 from Patent EP1572962. JD359547 - Sequence 340571 from Patent EP1572962. JD066963 - Sequence 47987 from Patent EP1572962. JD508860 - Sequence 489884 from Patent EP1572962. JD049204 - Sequence 30228 from Patent EP1572962. JD290716 - Sequence 271740 from Patent EP1572962. JD057498 - Sequence 38522 from Patent EP1572962. JD309217 - Sequence 290241 from Patent EP1572962. JD348920 - Sequence 329944 from Patent EP1572962. JD509515 - Sequence 490539 from Patent EP1572962. JD468530 - Sequence 449554 from Patent EP1572962. JD539281 - Sequence 520305 from Patent EP1572962. JD208222 - Sequence 189246 from Patent EP1572962. JD213960 - Sequence 194984 from Patent EP1572962. JD319016 - Sequence 300040 from Patent EP1572962. JD267010 - Sequence 248034 from Patent EP1572962. JD315469 - Sequence 296493 from Patent EP1572962. JD183056 - Sequence 164080 from Patent EP1572962. JD109599 - Sequence 90623 from Patent EP1572962. JD400304 - Sequence 381328 from Patent EP1572962. JD050465 - Sequence 31489 from Patent EP1572962. JD162750 - Sequence 143774 from Patent EP1572962. JD087238 - Sequence 68262 from Patent EP1572962. JD260845 - Sequence 241869 from Patent EP1572962. JD357304 - Sequence 338328 from Patent EP1572962. JD202159 - Sequence 183183 from Patent EP1572962. JD320200 - Sequence 301224 from Patent EP1572962. JD310210 - Sequence 291234 from Patent EP1572962. JD122450 - Sequence 103474 from Patent EP1572962. JD330692 - Sequence 311716 from Patent EP1572962. JD359061 - Sequence 340085 from Patent EP1572962. JD127397 - Sequence 108421 from Patent EP1572962. JD133462 - Sequence 114486 from Patent EP1572962. JD544188 - Sequence 525212 from Patent EP1572962. JD498741 - Sequence 479765 from Patent EP1572962. JD305943 - Sequence 286967 from Patent EP1572962. JD551350 - Sequence 532374 from Patent EP1572962. JD434474 - Sequence 415498 from Patent EP1572962. JD207026 - Sequence 188050 from Patent EP1572962. JD487015 - Sequence 468039 from Patent EP1572962. JD499547 - Sequence 480571 from Patent EP1572962. JD300328 - Sequence 281352 from Patent EP1572962. JD073154 - Sequence 54178 from Patent EP1572962. JD093262 - Sequence 74286 from Patent EP1572962. JD263982 - Sequence 245006 from Patent EP1572962. JD198937 - Sequence 179961 from Patent EP1572962. JD549358 - Sequence 530382 from Patent EP1572962. JD548950 - Sequence 529974 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A8K5T2, AP2REP, HSPC122, KLF12_HUMAN, L0R3J4, NM_001400153, Q5VZM7, Q9UHZ0, Q9Y4X4, uc331lck.1, uc331lck.2 UCSC ID: ENST00000703967.1_4 RefSeq Accession: NM_001400136.1 Protein: Q9Y4X4 (aka KLF12_HUMAN or KLFC_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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