Human Gene KLF13 (ENST00000307145.4_5) from GENCODE V47lift37

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Description: Kruppel like factor 13, transcript variant 1 (from RefSeq NM_015995.4)
Gencode Transcript: ENST00000307145.4_5
Gencode Gene: ENSG00000169926.11_9
Transcript (Including UTRs)
Position: hg19 chr15:31,619,038-31,670,102 Size: 51,065 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr15:31,619,416-31,664,502 Size: 45,087 Coding Exon Count: 2

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names
GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr15:31,619,038-31,670,102)			mRNA (may differ from genome)		Protein (288 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: KLF13 Diseases sorted by gene-association score: chromosome 15q13.3 microdeletion syndrome (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D014212 Tretinoin C028451 3,4,3',4'-tetrachlorobiphenyl C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001554 Benzene D001564 Benzo(a)pyrene D020111 Chlorodiphenyl (54% Chlorine) D004390 Chlorpyrifos D002794 Choline D002994 Clofibrate D003520 Cyclophosphamide D003907 Dexamethasone D004041 Dietary Fats D004054 Diethylstilbestrol D004958 Estradiol D004997 Ethinyl Estradiol D005492 Folic Acid D008715 Methionine D008727 Methotrexate D018817 N-Methyl-3,4-methylenedioxyamphetamine C568608 PCI 5002 D010634 Phenobarbital C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine D053260 Soot D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid D015032 Zinc C006632 arsenic trioxide C044887 beta-methylcholine C018021 cobaltous chloride C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 34.87 RPKM in Brain - Cerebellum Total median expression: 767.57 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-199.40	378	-0.528	Picture	PostScript	Text
3' UTR	-2196.10	5600	-0.392	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
		Ensembl

Descriptions from all associated GenBank mRNAs


	AF132599 - Homo sapiens RANTES factor of late activated T lymphocytes-1 mRNA, complete cds. BC035503 - Homo sapiens Kruppel-like factor 13, mRNA (cDNA clone IMAGE:4563309). BC010438 - Homo sapiens Kruppel-like factor 13, mRNA (cDNA clone MGC:4201 IMAGE:2823301), complete cds. BC013946 - Homo sapiens Kruppel-like factor 13, mRNA (cDNA clone MGC:2531 IMAGE:2823301), complete cds. DQ595388 - Homo sapiens piRNA piR-61500, complete sequence. BC012741 - Homo sapiens Kruppel-like factor 13, mRNA (cDNA clone MGC:15271 IMAGE:3940815), complete cds. JC513953 - Sequence 4206 from Patent WO2014113089. LQ071541 - Sequence 1865 from Patent EP2964234. AF150628 - Homo sapiens transcription factor NSLP1 mRNA, complete cds. JD129017 - Sequence 110041 from Patent EP1572962. KJ534876 - Homo sapiens clone KLF13_iso-A_adult-A15 Kruppel-like factor 13 isoform A (KLF13) mRNA, partial cds, alternatively spliced. KJ535015 - Homo sapiens clone KLF13_iso-B_adult-A13 Kruppel-like factor 13 isoform B (KLF13) mRNA, complete cds, alternatively spliced. DQ587638 - Homo sapiens piRNA piR-54750, complete sequence. JD117657 - Sequence 98681 from Patent EP1572962. AL390127 - Homo sapiens mRNA; cDNA DKFZp761P06121 (from clone DKFZp761P06121). DQ598126 - Homo sapiens piRNA piR-36192, complete sequence. DQ574999 - Homo sapiens piRNA piR-43111, complete sequence. BC012782 - Homo sapiens Kruppel-like factor 13, mRNA (cDNA clone IMAGE:3943625), partial cds. BC064552 - Homo sapiens cDNA clone IMAGE:5553940, partial cds. DQ575850 - Homo sapiens piRNA piR-43962, complete sequence. DQ595098 - Homo sapiens piRNA piR-61210, complete sequence.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000307145.1, ENST00000307145.2, ENST00000307145.3, hCG_38887 , KLF13 , NM_015995, uc317nzs.1, uc317nzs.2, X5DNR2, X5DNR2_HUMAN UCSC ID: ENST00000307145.4_5 RefSeq Accession: NM_015995.4

GeneReviews for This Gene


	GeneReviews article(s) related to gene KLF13: mdel15q13_3 (15q13.3 Recurrent Deletion)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.