Human Gene KLF14 (ENST00000583337.4_8) from GENCODE V47lift37
  Description: Kruppel like factor 14 (from RefSeq NM_138693.4)
Gencode Transcript: ENST00000583337.4_8
Gencode Gene: ENSG00000266265.4_10
Transcript (Including UTRs)
   Position: hg19 chr7:130,415,525-130,418,967 Size: 3,443 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr7:130,417,889-130,418,860 Size: 972 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:130,415,525-130,418,967)mRNA (may differ from genome)Protein (322 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KLF14_HUMAN
DESCRIPTION: RecName: Full=Krueppel-like factor 14; AltName: Full=Basic transcription element-binding protein 5; Short=BTE-binding protein 5; AltName: Full=Transcription factor BTEB5;
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.80107-0.578 Picture PostScript Text
3' UTR -773.502349-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q8TD94
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  DQ534757 - Homo sapiens Kruppel-like factor 14 (KLF14) mRNA, complete cds.
AF490374 - Homo sapiens BTEB5 mRNA, complete cds.
JD204021 - Sequence 185045 from Patent EP1572962.
JD360997 - Sequence 342021 from Patent EP1572962.
JD248431 - Sequence 229455 from Patent EP1572962.
JD060345 - Sequence 41369 from Patent EP1572962.
JD519166 - Sequence 500190 from Patent EP1572962.
JD103153 - Sequence 84177 from Patent EP1572962.
JD271935 - Sequence 252959 from Patent EP1572962.
JD423770 - Sequence 404794 from Patent EP1572962.
JD060878 - Sequence 41902 from Patent EP1572962.
BC160035 - Synthetic construct Homo sapiens clone IMAGE:100063971, MGC:193150 Kruppel-like factor 14 (KLF14) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A075B756, A4D1N0, BTEB5, ENST00000583337.1, ENST00000583337.2, ENST00000583337.3, KLF14_HUMAN, NM_138693, Q19A42, Q19A43, Q8TD94, uc326mgr.1, uc326mgr.2
UCSC ID: ENST00000583337.4_8
RefSeq Accession: NM_000014.6
Protein: Q8TD94 (aka KLF14_HUMAN or KLFE_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.