ID:KLF2_HUMAN DESCRIPTION: RecName: Full=Krueppel-like factor 2; AltName: Full=Lung krueppel-like factor; FUNCTION: Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity). SUBUNIT: Interacts with WWP1. SUBCELLULAR LOCATION: Nucleus (By similarity). PTM: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 3 C2H2-type zinc fingers. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/klf2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5W3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000902 cell morphogenesis GO:0001701 in utero embryonic development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0032715 negative regulation of interleukin-6 production GO:0034101 erythrocyte homeostasis GO:0034616 response to laminar fluid shear stress GO:0035264 multicellular organism growth GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0040029 regulation of gene expression, epigenetic GO:0043249 erythrocyte maturation GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051247 positive regulation of protein metabolic process GO:0060509 Type I pneumocyte differentiation GO:0070301 cellular response to hydrogen peroxide GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071407 cellular response to organic cyclic compound GO:0071409 cellular response to cycloheximide GO:0071498 cellular response to fluid shear stress GO:0071499 cellular response to laminar fluid shear stress GO:0097533 cellular stress response to acid chemical GO:1901653 cellular response to peptide GO:1903671 negative regulation of sprouting angiogenesis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
