Human Gene KLHL15 (ENST00000328046.8_6) from GENCODE V47lift37
  Description: kelch like family member 15 (from RefSeq NM_030624.3)
Gencode Transcript: ENST00000328046.8_6
Gencode Gene: ENSG00000174010.10_12
Transcript (Including UTRs)
   Position: hg19 chrX:24,001,837-24,045,303 Size: 43,467 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chrX:24,006,038-24,024,810 Size: 18,773 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:24,001,837-24,045,303)mRNA (may differ from genome)Protein (604 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KLHL15
Diseases sorted by gene-association score: mental retardation, x-linked 103* (919)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.06 RPKM in Testis
Total median expression: 114.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -98.60256-0.385 Picture PostScript Text
3' UTR -969.304201-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  LF211573 - JP 2014500723-A/19076: Polycomb-Associated Non-Coding RNAs.
AL834313 - Homo sapiens mRNA; cDNA DKFZp434M0516 (from clone DKFZp434M0516).
AB051464 - Homo sapiens mRNA for KIAA1677 protein, partial cds.
JD327339 - Sequence 308363 from Patent EP1572962.
JD493464 - Sequence 474488 from Patent EP1572962.
JD095699 - Sequence 76723 from Patent EP1572962.
JD311246 - Sequence 292270 from Patent EP1572962.
JD086748 - Sequence 67772 from Patent EP1572962.
JD510655 - Sequence 491679 from Patent EP1572962.
JD110761 - Sequence 91785 from Patent EP1572962.
JD022569 - Sequence 3593 from Patent EP1572962.
JD301921 - Sequence 282945 from Patent EP1572962.
LF381458 - JP 2014500723-A/188961: Polycomb-Associated Non-Coding RNAs.
JD198865 - Sequence 179889 from Patent EP1572962.
JD454361 - Sequence 435385 from Patent EP1572962.
JD245279 - Sequence 226303 from Patent EP1572962.
JD435929 - Sequence 416953 from Patent EP1572962.
JD528277 - Sequence 509301 from Patent EP1572962.
LF381457 - JP 2014500723-A/188960: Polycomb-Associated Non-Coding RNAs.
JD048950 - Sequence 29974 from Patent EP1572962.
JD166568 - Sequence 147592 from Patent EP1572962.
JD488467 - Sequence 469491 from Patent EP1572962.
JD425281 - Sequence 406305 from Patent EP1572962.
JD438911 - Sequence 419935 from Patent EP1572962.
JD503795 - Sequence 484819 from Patent EP1572962.
JD360618 - Sequence 341642 from Patent EP1572962.
JD065410 - Sequence 46434 from Patent EP1572962.
JD197530 - Sequence 178554 from Patent EP1572962.
JD429397 - Sequence 410421 from Patent EP1572962.
JD067983 - Sequence 49007 from Patent EP1572962.
JD156142 - Sequence 137166 from Patent EP1572962.
JD300529 - Sequence 281553 from Patent EP1572962.
JD082499 - Sequence 63523 from Patent EP1572962.
BC015415 - Homo sapiens kelch-like 15 (Drosophila), mRNA (cDNA clone IMAGE:4395166), partial cds.
JD261724 - Sequence 242748 from Patent EP1572962.
JD066872 - Sequence 47896 from Patent EP1572962.
JD080327 - Sequence 61351 from Patent EP1572962.
JD440424 - Sequence 421448 from Patent EP1572962.
JD330590 - Sequence 311614 from Patent EP1572962.
JD082836 - Sequence 63860 from Patent EP1572962.
JD433635 - Sequence 414659 from Patent EP1572962.
AK057298 - Homo sapiens cDNA FLJ32736 fis, clone TESTI2001237, weakly similar to RING CANAL PROTEIN.
BC109058 - Homo sapiens kelch-like 15 (Drosophila), mRNA (cDNA clone MGC:126148 IMAGE:40033682), complete cds.
BC109059 - Homo sapiens kelch-like 15 (Drosophila), mRNA (cDNA clone MGC:126149 IMAGE:40033683), complete cds.
EU794630 - Homo sapiens epididymis secretory protein Li 305 (HEL-S-305) mRNA, complete cds.
GQ891312 - Homo sapiens clone HEL-S-35a epididymis secretory sperm binding protein mRNA, complete cds.
KJ894811 - Synthetic construct Homo sapiens clone ccsbBroadEn_04205 KLHL15 gene, encodes complete protein.
AB384623 - Synthetic construct DNA, clone: pF1KA1677, Homo sapiens KLHL15 gene for kelch-like protein 15, complete cds, without stop codon, in Flexi system.
LF381456 - JP 2014500723-A/188959: Polycomb-Associated Non-Coding RNAs.
LF381445 - JP 2014500723-A/188948: Polycomb-Associated Non-Coding RNAs.
JD235418 - Sequence 216442 from Patent EP1572962.
MA447150 - JP 2018138019-A/19076: Polycomb-Associated Non-Coding RNAs.
MA617035 - JP 2018138019-A/188961: Polycomb-Associated Non-Coding RNAs.
MA617034 - JP 2018138019-A/188960: Polycomb-Associated Non-Coding RNAs.
MA617033 - JP 2018138019-A/188959: Polycomb-Associated Non-Coding RNAs.
MA617022 - JP 2018138019-A/188948: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000328046.1, ENST00000328046.2, ENST00000328046.3, ENST00000328046.4, ENST00000328046.5, ENST00000328046.6, ENST00000328046.7, hCG_1642367 , HEL-S-305 , KLHL15 , NM_030624, uc317skl.1, uc317skl.2, V9HWF1, V9HWF1_HUMAN
UCSC ID: ENST00000328046.8_6
RefSeq Accession: NM_030624.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.