Human Gene KLHL42 (ENST00000381271.7_4) from GENCODE V47lift37
  Description: kelch like family member 42 (from RefSeq NM_020782.2)
Gencode Transcript: ENST00000381271.7_4
Gencode Gene: ENSG00000087448.11_10
Transcript (Including UTRs)
   Position: hg19 chr12:27,933,166-27,955,973 Size: 22,808 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr12:27,933,264-27,951,099 Size: 17,836 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:27,933,166-27,955,973)mRNA (may differ from genome)Protein (505 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KLDC5_HUMAN
DESCRIPTION: RecName: Full=Kelch domain-containing protein 5;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 6 Kelch repeats.
SEQUENCE CAUTION: Sequence=AAH28742.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.37 RPKM in Bladder
Total median expression: 395.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.5098-0.566 Picture PostScript Text
3' UTR -1265.804874-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1

Pfam Domains:
PF01344 - Kelch motif
PF07707 - BTB And C-terminal Kelch
PF13415 - Galactose oxidase, central domain
PF13964 - Kelch motif

SCOP Domains:
117281 - Kelch motif
101898 - NHL repeat
50965 - Galactose oxidase, central domain
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q9P2K6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0000209 protein polyubiquitination
GO:0007049 cell cycle
GO:0016567 protein ubiquitination
GO:0032886 regulation of microtubule-based process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687 post-translational protein modification
GO:0051301 cell division

Cellular Component:
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0031463 Cul3-RING ubiquitin ligase complex


-  Descriptions from all associated GenBank mRNAs
  BC028742 - Homo sapiens kelch domain containing 5, mRNA (cDNA clone IMAGE:5264081), partial cds.
JD476094 - Sequence 457118 from Patent EP1572962.
AK095405 - Homo sapiens cDNA FLJ38086 fis, clone CTONG2018632, highly similar to Kelch domain-containing protein 5.
JD225660 - Sequence 206684 from Patent EP1572962.
BC137116 - Homo sapiens kelch domain containing 5, mRNA (cDNA clone MGC:168736 IMAGE:9021113), complete cds.
BC137117 - Homo sapiens kelch domain containing 5, mRNA (cDNA clone MGC:168737 IMAGE:9021114), complete cds.
BC108669 - Homo sapiens kelch domain containing 5, mRNA (cDNA clone MGC:131714 IMAGE:6173072), complete cds.
AB528162 - Synthetic construct DNA, clone: pF1KB5915, Homo sapiens KLHDC5 gene for kelch domain containing 5, without stop codon, in Flexi system.
AB587405 - Synthetic construct DNA, clone: pF1KB5915, Homo sapiens KLHDC5 gene for kelch domain containing 5, without stop codon, in Flexi system.
EU446834 - Synthetic construct Homo sapiens clone IMAGE:100069933; IMAGE:100012043; FLH257133.01L kelch domain containing 5 (KLHDC5) gene, encodes complete protein.
AB037761 - Homo sapiens mRNA for KIAA1340 protein, partial cds.
JD353533 - Sequence 334557 from Patent EP1572962.
JD204713 - Sequence 185737 from Patent EP1572962.
JD284294 - Sequence 265318 from Patent EP1572962.
JD067099 - Sequence 48123 from Patent EP1572962.
JD245656 - Sequence 226680 from Patent EP1572962.
JD332793 - Sequence 313817 from Patent EP1572962.
JD531344 - Sequence 512368 from Patent EP1572962.
JD298747 - Sequence 279771 from Patent EP1572962.
JD528506 - Sequence 509530 from Patent EP1572962.
JD040409 - Sequence 21433 from Patent EP1572962.
JD052191 - Sequence 33215 from Patent EP1572962.
JD244619 - Sequence 225643 from Patent EP1572962.
JD357781 - Sequence 338805 from Patent EP1572962.
JD418988 - Sequence 400012 from Patent EP1572962.
JD351192 - Sequence 332216 from Patent EP1572962.
JD052023 - Sequence 33047 from Patent EP1572962.
JD192207 - Sequence 173231 from Patent EP1572962.
JD126377 - Sequence 107401 from Patent EP1572962.
JD358909 - Sequence 339933 from Patent EP1572962.
JD245350 - Sequence 226374 from Patent EP1572962.
JD282406 - Sequence 263430 from Patent EP1572962.
JD499021 - Sequence 480045 from Patent EP1572962.
JD313611 - Sequence 294635 from Patent EP1572962.
JD236415 - Sequence 217439 from Patent EP1572962.
JD040606 - Sequence 21630 from Patent EP1572962.
JD274316 - Sequence 255340 from Patent EP1572962.
JD320517 - Sequence 301541 from Patent EP1572962.
JD269112 - Sequence 250136 from Patent EP1572962.
JD490454 - Sequence 471478 from Patent EP1572962.
JD434283 - Sequence 415307 from Patent EP1572962.
JD502004 - Sequence 483028 from Patent EP1572962.
JD314494 - Sequence 295518 from Patent EP1572962.
JD113709 - Sequence 94733 from Patent EP1572962.
JD305027 - Sequence 286051 from Patent EP1572962.
JD352760 - Sequence 333784 from Patent EP1572962.
JD525634 - Sequence 506658 from Patent EP1572962.
JD416855 - Sequence 397879 from Patent EP1572962.
JD292581 - Sequence 273605 from Patent EP1572962.
JD185376 - Sequence 166400 from Patent EP1572962.
JD366548 - Sequence 347572 from Patent EP1572962.
JD517718 - Sequence 498742 from Patent EP1572962.
JD517719 - Sequence 498743 from Patent EP1572962.
JD217350 - Sequence 198374 from Patent EP1572962.
AK002197 - Homo sapiens cDNA FLJ11335 fis, clone PLACE1010630.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9P2K6 (Reactome details) participates in the following event(s):

R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-597592 Post-translational protein modification
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-392499 Metabolism of proteins
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000381271.1, ENST00000381271.2, ENST00000381271.3, ENST00000381271.4, ENST00000381271.5, ENST00000381271.6, KIAA1340, KLH42_HUMAN, KLHDC5, NM_020782, Q2VPK1, Q8N334, Q9P2K6, uc318qdq.1, uc318qdq.2
UCSC ID: ENST00000381271.7_4
RefSeq Accession: NM_020782.2
Protein: Q9P2K6 (aka KLDC5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.