Human Gene KLHL6 (ENST00000341319.8_7) from GENCODE V47lift37

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Description: kelch like family member 6 (from RefSeq NM_130446.4)
Gencode Transcript: ENST00000341319.8_7
Gencode Gene: ENSG00000172578.12_9
Transcript (Including UTRs)
Position: hg19 chr3:183,205,339-183,273,494 Size: 68,156 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr3:183,209,715-183,273,441 Size: 63,727 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:183,205,339-183,273,494)			mRNA (may differ from genome)		Protein (621 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: KLHL6_HUMAN DESCRIPTION: RecName: Full=Kelch-like protein 6; FUNCTION: Involved in B-lymphocyte antigen receptor signaling and germinal center formation (By similarity). TISSUE SPECIFICITY: Found in germinal center B-cells. SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 6 Kelch repeats. SEQUENCE CAUTION: Sequence=AAH32348.1; Type=Erroneous initiation; Sequence=AAL35594.1; Type=Erroneous initiation; Sequence=BAG37078.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: KLHL6 Diseases sorted by gene-association score: chronic lymphocytic leukemia (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C027576 4-hydroxy-2-nonenal D001564 Benzo(a)pyrene D004041 Dietary Fats D004147 Dioxins D004397 Fonofos D005839 Gentamicins D015735 Mifepristone D010278 Parathion C041786 palm oil C012568 terbufos

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.64 RPKM in Spleen Total median expression: 40.73 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-14.40	53	-0.272	Picture	PostScript	Text
3' UTR	-1539.34	4376	-0.352	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR017096 - Kelch-like_gigaxonin
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1

Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07646 - Kelch motif
PF07707 - BTB And C-terminal Kelch

SCOP Domains:
117281 - Kelch motif
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50985 - RCC1/BLIP-II
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like
51971 - Nucleotide-binding domain
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q8WZ60


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding Biological Process: GO:0002467 germinal center formation GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045893 positive regulation of transcription, DNA-templated GO:0050853 B cell receptor signaling pathway Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AF441792 - Homo sapiens kelch-like protein KLHL6 (KLHL6) mRNA, complete cds. BC032348 - Homo sapiens kelch-like 6 (Drosophila), mRNA (cDNA clone MGC:40562 IMAGE:5213743), complete cds. BX648370 - Homo sapiens mRNA; cDNA DKFZp686J13185 (from clone DKFZp686J13185). AK097125 - Homo sapiens cDNA FLJ39806 fis, clone SPLEN2008460. AK314473 - Homo sapiens cDNA, FLJ95278, highly similar to Homo sapiens kelch-like 6 (Drosophila) (KLHL6), mRNA. KJ903529 - Synthetic construct Homo sapiens clone ccsbBroadEn_12923 KLHL6 gene, encodes complete protein. DQ894788 - Synthetic construct Homo sapiens clone IMAGE:100009248; FLH178450.01L; RZPDo839D05127D kelch-like 6 (Drosophila) (KLHL6) gene, encodes complete protein. EU176275 - Synthetic construct Homo sapiens clone IMAGE:100006398; FLH178455.01X; RZPDo839B12250D kelch-like 6 (Drosophila) (KLHL6) gene, encodes complete protein. CU689348 - Synthetic construct Homo sapiens gateway clone IMAGE:100019937 5' read KLHL6 mRNA. BC037989 - Homo sapiens, Similar to kelch-like 6 (Drosophila), clone IMAGE:5538114, mRNA. JD244563 - Sequence 225587 from Patent EP1572962. AL833667 - Homo sapiens mRNA; cDNA DKFZp667I1621 (from clone DKFZp667I1621). AK024439 - Homo sapiens mRNA for FLJ00029 protein, partial cds. JD501812 - Sequence 482836 from Patent EP1572962. JD490396 - Sequence 471420 from Patent EP1572962. JD509111 - Sequence 490135 from Patent EP1572962. JD503764 - Sequence 484788 from Patent EP1572962. JD233716 - Sequence 214740 from Patent EP1572962. JD300030 - Sequence 281054 from Patent EP1572962. JD237538 - Sequence 218562 from Patent EP1572962. JD411755 - Sequence 392779 from Patent EP1572962. JD050609 - Sequence 31633 from Patent EP1572962. JD412578 - Sequence 393602 from Patent EP1572962. JD228187 - Sequence 209211 from Patent EP1572962. JD168661 - Sequence 149685 from Patent EP1572962. JD484800 - Sequence 465824 from Patent EP1572962. JD176931 - Sequence 157955 from Patent EP1572962. JD073869 - Sequence 54893 from Patent EP1572962. JD192802 - Sequence 173826 from Patent EP1572962. JD274620 - Sequence 255644 from Patent EP1572962. JD158501 - Sequence 139525 from Patent EP1572962. JD207493 - Sequence 188517 from Patent EP1572962. JD355467 - Sequence 336491 from Patent EP1572962. JD378663 - Sequence 359687 from Patent EP1572962. JD055602 - Sequence 36626 from Patent EP1572962. JD228088 - Sequence 209112 from Patent EP1572962. JD051227 - Sequence 32251 from Patent EP1572962. JD052902 - Sequence 33926 from Patent EP1572962. JD131144 - Sequence 112168 from Patent EP1572962. JD126599 - Sequence 107623 from Patent EP1572962. JD085412 - Sequence 66436 from Patent EP1572962. JD064215 - Sequence 45239 from Patent EP1572962. JD080541 - Sequence 61565 from Patent EP1572962. JD219413 - Sequence 200437 from Patent EP1572962. JD494193 - Sequence 475217 from Patent EP1572962. JD281274 - Sequence 262298 from Patent EP1572962. JD061620 - Sequence 42644 from Patent EP1572962. JD492235 - Sequence 473259 from Patent EP1572962. JD248897 - Sequence 229921 from Patent EP1572962. JD048665 - Sequence 29689 from Patent EP1572962. JD528483 - Sequence 509507 from Patent EP1572962. JD238923 - Sequence 219947 from Patent EP1572962. JD356678 - Sequence 337702 from Patent EP1572962. JD256631 - Sequence 237655 from Patent EP1572962. JD342365 - Sequence 323389 from Patent EP1572962. JD488487 - Sequence 469511 from Patent EP1572962. AK097976 - Homo sapiens cDNA FLJ40657 fis, clone THYMU2019436. JD127998 - Sequence 109022 from Patent EP1572962. JD462380 - Sequence 443404 from Patent EP1572962. JD076533 - Sequence 57557 from Patent EP1572962. JD246957 - Sequence 227981 from Patent EP1572962. JD425790 - Sequence 406814 from Patent EP1572962. JD123836 - Sequence 104860 from Patent EP1572962. JD054490 - Sequence 35514 from Patent EP1572962. JD287991 - Sequence 269015 from Patent EP1572962. JD179907 - Sequence 160931 from Patent EP1572962. JD118056 - Sequence 99080 from Patent EP1572962. JD413228 - Sequence 394252 from Patent EP1572962. JD055040 - Sequence 36064 from Patent EP1572962. JD144088 - Sequence 125112 from Patent EP1572962. JD026898 - Sequence 7922 from Patent EP1572962. JD036175 - Sequence 17199 from Patent EP1572962. JD019660 - Sequence 684 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B2RB31, D3DNS8, ENST00000341319.1, ENST00000341319.2, ENST00000341319.3, ENST00000341319.4, ENST00000341319.5, ENST00000341319.6, ENST00000341319.7, KLHL6_HUMAN, NM_130446, Q8N5I1, Q8N892, Q8WZ60, uc317vzh.1, uc317vzh.2 UCSC ID: ENST00000341319.8_7 RefSeq Accession: NM_130446.4 Protein: Q8WZ60 (aka KLHL6_HUMAN or KHL6_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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