Human Gene KLRC2 (ENST00000381902.7_10) from GENCODE V47lift37
  Description: killer cell lectin like receptor C2 (from RefSeq NM_002260.4)
Gencode Transcript: ENST00000381902.7_10
Gencode Gene: ENSG00000205809.11_16
Transcript (Including UTRs)
   Position: hg19 chr12:10,583,198-10,588,609 Size: 5,412 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr12:10,583,716-10,588,585 Size: 4,870 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:10,583,198-10,588,609)mRNA (may differ from genome)Protein (231 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NKG2C_HUMAN
DESCRIPTION: RecName: Full=NKG2-C type II integral membrane protein; AltName: Full=CD159 antigen-like family member C; AltName: Full=NK cell receptor C; AltName: Full=NKG2-C-activating NK receptor; AltName: CD_antigen=CD159c;
FUNCTION: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
SUBUNIT: Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.
INTERACTION: O43914:TYROBP; NbExp=2; IntAct=EBI-3862171, EBI-2214794;
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
TISSUE SPECIFICITY: Natural killer cells.
POLYMORPHISM: Two alleles are known. The sequence shown is that of allele NKG2-C*01.
SIMILARITY: Contains 1 C-type lectin domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KLRC2
Diseases sorted by gene-association score: trachoma (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.05 RPKM in Brain - Hypothalamus
Total median expression: 20.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00240.000 Picture PostScript Text
3' UTR -112.30518-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001304 - C-type_lectin
IPR016186 - C-type_lectin-like
IPR016187 - C-type_lectin_fold

Pfam Domains:
PF00059 - Lectin C-type domain

SCOP Domains:
56436 - C-type lectin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2L35 - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P26717
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0023024 MHC class I protein complex binding
GO:0030246 carbohydrate binding
GO:1990405 protein antigen binding

Biological Process:
GO:0002228 natural killer cell mediated immunity
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0045087 innate immune response

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex


-  Descriptions from all associated GenBank mRNAs
  AF461157 - Homo sapiens NKG2E mRNA, complete cds.
AF350017 - Homo sapiens NKG2E (NKG2E) mRNA, NKG2E03 allele, complete cds.
AK295525 - Homo sapiens cDNA FLJ60557 complete cds, highly similar to NKG2-C type II integral membrane protein.
BC106069 - Homo sapiens killer cell lectin-like receptor subfamily C, member 2, mRNA (cDNA clone IMAGE:5104202), partial cds.
X54869 - Human mRNA for NKG2-C gene.
JD314230 - Sequence 295254 from Patent EP1572962.
JD343333 - Sequence 324357 from Patent EP1572962.
JD171346 - Sequence 152370 from Patent EP1572962.
JD145807 - Sequence 126831 from Patent EP1572962.
JD081200 - Sequence 62224 from Patent EP1572962.
BC112039 - Homo sapiens killer cell lectin-like receptor subfamily C, member 2, mRNA (cDNA clone MGC:138244 IMAGE:8327507), complete cds.
BC093644 - Homo sapiens killer cell lectin-like receptor subfamily C, member 2, mRNA (cDNA clone MGC:120679 IMAGE:7939489), complete cds.
Y13055 - Homo sapiens mRNA for NKG2-CII activating NK receptor.
AF260134 - Homo sapiens NK cell receptor C (NKG2-C) mRNA, NKG2-C*02 allele, complete cds.
KJ897101 - Synthetic construct Homo sapiens clone ccsbBroadEn_06495 KLRC2 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity

Reactome (by CSHL, EBI, and GO)

Protein P26717 (Reactome details) participates in the following event(s):

R-HSA-2172126 DAP12 interacts with NKG2C
R-HSA-210289 Recruitment of SYK to p-DAP12
R-HSA-2395439 Phosphorylation of DAP12
R-HSA-2395412 Phosphorylation of SYK
R-HSA-2424482 p85 regulatory unit of PI3K binds p-6Y-SYK
R-HSA-2395801 Phosphorylation of LAT by p-SYK
R-HSA-2396594 Phosphorylation of SLP-76 by p-SYK
R-HSA-2424484 Phosphorylation of BTK by p-SYK
R-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYK
R-HSA-2424480 PI3K phosphorylates PIP2 to PIP3
R-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYK
R-HSA-2172127 DAP12 interactions
R-HSA-168249 Innate Immune System
R-HSA-2424491 DAP12 signaling
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000381902.1, ENST00000381902.2, ENST00000381902.3, ENST00000381902.4, ENST00000381902.5, ENST00000381902.6, NKG2C , NKG2C_HUMAN, NM_002260, O43802, P26717, Q52M74, Q9NR42, uc318qnr.1, uc318qnr.2
UCSC ID: ENST00000381902.7_10
RefSeq Accession: NM_002260.4
Protein: P26717 (aka NKG2C_HUMAN or NKGC_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.