ID:IMA7_HUMAN DESCRIPTION: RecName: Full=Importin subunit alpha-7; AltName: Full=Karyopherin subunit alpha-6; FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. SUBUNIT: Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the importin alpha family. SIMILARITY: Contains 10 ARM repeats. SIMILARITY: Contains 1 IBB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48371 - ARM repeat 48431 - Lipovitellin-phosvitin complex, superhelical domain 53850 - Periplasmic binding protein-like II
ModBase Predicted Comparative 3D Structure on O60684
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008139 nuclear localization sequence binding GO:0008565 protein transporter activity GO:0061608 nuclear import signal receptor activity
Biological Process: GO:0006606 protein import into nucleus GO:0006607 NLS-bearing protein import into nucleus GO:0015031 protein transport GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060135 maternal process involved in female pregnancy
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
