ID:KRR1_HUMAN DESCRIPTION: RecName: Full=KRR1 small subunit processome component homolog; AltName: Full=HIV-1 Rev-binding protein 2; AltName: Full=KRR-R motif-containing protein 1; AltName: Full=Rev-interacting protein 1; Short=Rip-1; FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). SUBUNIT: Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR. SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Translocates from cytoplasm to nucleus after exposure to HIV- 1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR. SIMILARITY: Belongs to the KRR1 family. SIMILARITY: Contains 1 KH domain. SEQUENCE CAUTION: Sequence=AAB00557.1; Type=Frameshift; Positions=265, 300; Sequence=AAH05225.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 54791 - Eukaryotic type KH-domain (KH-domain type I) 54814 - Prokaryotic type KH domain (KH-domain type II)
ModBase Predicted Comparative 3D Structure on Q13601
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
CU680347 - Synthetic construct Homo sapiens gateway clone IMAGE:100018666 3' read GLIPR1 mRNA. AK024153 - Homo sapiens cDNA FLJ14091 fis, clone MAMMA1000266. AK093825 - Homo sapiens cDNA FLJ36506 fis, clone TRACH2001060. JD229245 - Sequence 210269 from Patent EP1572962. BC033887 - Homo sapiens KRR1, small subunit (SSU) processome component, homolog (yeast), mRNA (cDNA clone MGC:33073 IMAGE:5268517), complete cds. JD068857 - Sequence 49881 from Patent EP1572962. JD553313 - Sequence 534337 from Patent EP1572962. JD097495 - Sequence 78519 from Patent EP1572962. JD305853 - Sequence 286877 from Patent EP1572962. JD314670 - Sequence 295694 from Patent EP1572962. JD062172 - Sequence 43196 from Patent EP1572962. JD509918 - Sequence 490942 from Patent EP1572962. JD206642 - Sequence 187666 from Patent EP1572962. JD483704 - Sequence 464728 from Patent EP1572962. BC026107 - Homo sapiens KRR1, small subunit (SSU) processome component, homolog (yeast), mRNA (cDNA clone MGC:33072 IMAGE:4827704), complete cds. JD383263 - Sequence 364287 from Patent EP1572962. JD242525 - Sequence 223549 from Patent EP1572962. BC016778 - Homo sapiens KRR1, small subunit (SSU) processome component, homolog (yeast), mRNA (cDNA clone MGC:23749 IMAGE:4106298), complete cds. JD120343 - Sequence 101367 from Patent EP1572962. EF010919 - Homo sapiens HRB2 variant B mRNA, complete cds, alternatively spliced. AK313687 - Homo sapiens cDNA, FLJ94276, highly similar to Homo sapiens HIV-1 rev binding protein 2 (HRB2), mRNA. DQ893552 - Synthetic construct clone IMAGE:100006182; FLH195060.01X; RZPDo839F0383D KRR1, small subunit (SSU) processome component, homolog (yeast) (KRR1) gene, encodes complete protein. DQ893553 - Synthetic construct clone IMAGE:100006183; FLH195061.01X; RZPDo839G0383D KRR1, small subunit (SSU) processome component, homolog (yeast) (KRR1) gene, encodes complete protein. DQ893554 - Synthetic construct clone IMAGE:100006184; FLH195062.01X; RZPDo839H0383D KRR1, small subunit (SSU) processome component, homolog (yeast) (KRR1) gene, encodes complete protein. KJ898357 - Synthetic construct Homo sapiens clone ccsbBroadEn_07751 KRR1 gene, encodes complete protein. KJ898358 - Synthetic construct Homo sapiens clone ccsbBroadEn_07752 KRR1 gene, encodes complete protein. KJ898359 - Synthetic construct Homo sapiens clone ccsbBroadEn_07753 KRR1 gene, encodes complete protein. DQ896515 - Synthetic construct Homo sapiens clone IMAGE:100010975; FLH195058.01L; RZPDo839D0383D KRR1, small subunit (SSU) processome component, homolog (yeast) (KRR1) gene, encodes complete protein. BC014034 - Homo sapiens HIV-1 Rev binding protein 2, mRNA (cDNA clone IMAGE:4329064). U55766 - Human Rev interacting protein Rip-1 mRNA, complete cds. BC005225 - Homo sapiens KRR1, small subunit (SSU) processome component, homolog (yeast), mRNA (cDNA clone IMAGE:3685682), partial cds. CU689792 - Synthetic construct Homo sapiens gateway clone IMAGE:100019162 5' read KRR1 mRNA. AK297602 - Homo sapiens cDNA FLJ57399 complete cds, highly similar to HIV-1 Rev-binding protein 2. AK022133 - Homo sapiens cDNA FLJ12071 fis, clone HEMBB1002359.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q13601 (Reactome details) participates in the following event(s):
R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
