Human Gene KRT33B (ENST00000251646.8_7) from GENCODE V47lift37
  Description: keratin 33B (from RefSeq NM_002279.5)
Gencode Transcript: ENST00000251646.8_7
Gencode Gene: ENSG00000131738.11_9
Transcript (Including UTRs)
   Position: hg19 chr17:39,519,750-39,526,065 Size: 6,316 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr17:39,520,088-39,526,002 Size: 5,915 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:39,519,750-39,526,065)mRNA (may differ from genome)Protein (404 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KT33B_HUMAN
DESCRIPTION: RecName: Full=Keratin, type I cuticular Ha3-II; AltName: Full=Hair keratin, type I Ha3-II; AltName: Full=Keratin-33B; Short=K33B;
MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
SIMILARITY: Belongs to the intermediate filament family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.26 RPKM in Testis
Total median expression: 1.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.0063-0.270 Picture PostScript Text
3' UTR -99.00338-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016044 - F
IPR001664 - IF
IPR018039 - Intermediate_filament_CS
IPR002957 - Keratin_I

Pfam Domains:
PF00038 - Intermediate filament protein

SCOP Domains:
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region
90257 - Myosin rod fragments

ModBase Predicted Comparative 3D Structure on Q14525
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005515 protein binding

Biological Process:
GO:0007568 aging
GO:0031424 keratinization
GO:0042633 hair cycle
GO:0070268 cornification

Cellular Component:
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  X82634 - Homo sapiens mRNA for hair keratin acidic 3-II.
BC009971 - Homo sapiens keratin 33B, mRNA (cDNA clone MGC:15362 IMAGE:4310076), complete cds.
JD379864 - Sequence 360888 from Patent EP1572962.
JD258354 - Sequence 239378 from Patent EP1572962.
JD076834 - Sequence 57858 from Patent EP1572962.
JD058863 - Sequence 39887 from Patent EP1572962.
DQ893452 - Synthetic construct clone IMAGE:100006082; FLH192946.01X; RZPDo839B0178D keratin 33B (KRT33B) gene, encodes complete protein.
DQ896286 - Synthetic construct Homo sapiens clone IMAGE:100010746; FLH192942.01L; RZPDo839B0168D keratin 33B (KRT33B) gene, encodes complete protein.
KJ891527 - Synthetic construct Homo sapiens clone ccsbBroadEn_00921 KRT33B gene, encodes complete protein.
CU679547 - Synthetic construct Homo sapiens gateway clone IMAGE:100019255 5' read KRT33B mRNA.
JD147016 - Sequence 128040 from Patent EP1572962.
JD119466 - Sequence 100490 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14525 (Reactome details) participates in the following event(s):

R-HSA-6805546 Keratin type I binds keratin type II
R-HSA-6805573 Keratin type I/type II heterodimers form tetramers
R-HSA-6806613 Keratin tetramers bind to form unit length filaments
R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000251646.1, ENST00000251646.2, ENST00000251646.3, ENST00000251646.4, ENST00000251646.5, ENST00000251646.6, ENST00000251646.7, HHA3-II, HKA3B, KRTHA3B, KT33B_HUMAN, NM_002279, O76010, Q14525, uc317fex.1, uc317fex.2
UCSC ID: ENST00000251646.8_7
RefSeq Accession: NM_002279.5
Protein: Q14525 (aka KT33B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.