Human Gene KRT35 (ENST00000246639.7_6) from GENCODE V47lift37
  Description: keratin 35 (from RefSeq NM_002280.6)
Gencode Transcript: ENST00000246639.7_6
Gencode Gene: ENSG00000197079.9_9
Transcript (Including UTRs)
   Position: hg19 chr17:39,632,962-39,637,403 Size: 4,442 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr17:39,633,308-39,637,349 Size: 4,042 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:39,632,962-39,637,403)mRNA (may differ from genome)Protein (455 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KRT35_HUMAN
DESCRIPTION: RecName: Full=Keratin, type I cuticular Ha5; AltName: Full=Hair keratin, type I Ha5; AltName: Full=Keratin-35; Short=K35;
TISSUE SPECIFICITY: Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.
MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
SIMILARITY: Belongs to the intermediate filament family.
SEQUENCE CAUTION: Sequence=CAA62286.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA76387.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KRT35
Diseases sorted by gene-association score: skin pilomatrix carcinoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.09 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 0.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.9054-0.331 Picture PostScript Text
3' UTR -111.20346-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016044 - F
IPR001664 - IF
IPR018039 - Intermediate_filament_CS
IPR002957 - Keratin_I

Pfam Domains:
PF00038 - Intermediate filament protein

SCOP Domains:
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region
90257 - Myosin rod fragments

ModBase Predicted Comparative 3D Structure on Q92764
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity

Biological Process:
GO:0009653 anatomical structure morphogenesis
GO:0031424 keratinization
GO:0070268 cornification

Cellular Component:
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  X90763 - Homo sapiens mRNA for type I keratin.
JD515609 - Sequence 496633 from Patent EP1572962.
JD228852 - Sequence 209876 from Patent EP1572962.
JD228851 - Sequence 209875 from Patent EP1572962.
JD049101 - Sequence 30125 from Patent EP1572962.
JD406635 - Sequence 387659 from Patent EP1572962.
JD284423 - Sequence 265447 from Patent EP1572962.
JD384277 - Sequence 365301 from Patent EP1572962.
JD487911 - Sequence 468935 from Patent EP1572962.
BC140365 - Synthetic construct Homo sapiens clone IMAGE:100014396, MGC:173244 keratin 35 (KRT35) mRNA, encodes complete protein.
BC146508 - Synthetic construct Homo sapiens clone IMAGE:100014999, MGC:180172 keratin 35 (KRT35) mRNA, encodes complete protein.
AB463814 - Synthetic construct DNA, clone: pF1KB7222, Homo sapiens KRT35 gene for keratin 35, without stop codon, in Flexi system.
JD457148 - Sequence 438172 from Patent EP1572962.
JD260477 - Sequence 241501 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q92764 (Reactome details) participates in the following event(s):

R-HSA-6805546 Keratin type I binds keratin type II
R-HSA-6805573 Keratin type I/type II heterodimers form tetramers
R-HSA-6806613 Keratin tetramers bind to form unit length filaments
R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000246639.1, ENST00000246639.2, ENST00000246639.3, ENST00000246639.4, ENST00000246639.5, ENST00000246639.6, HHA5, HKA5, KRT35_HUMAN, KRTHA5, NM_002280, O76012, Q92651, Q92764, uc317etx.1, uc317etx.2
UCSC ID: ENST00000246639.7_6
RefSeq Accession: NM_002280.6
Protein: Q92764 (aka KRT35_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.