Human Gene KRT7 (ENST00000331817.6_4) from GENCODE V47lift37
  Description: keratin 7 (from RefSeq NM_005556.4)
Gencode Transcript: ENST00000331817.6_4
Gencode Gene: ENSG00000135480.17_9
Transcript (Including UTRs)
   Position: hg19 chr12:52,627,027-52,642,705 Size: 15,679 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr12:52,627,081-52,642,544 Size: 15,464 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:52,627,027-52,642,705)mRNA (may differ from genome)Protein (469 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K2C7_HUMAN
DESCRIPTION: RecName: Full=Keratin, type II cytoskeletal 7; AltName: Full=Cytokeratin-7; Short=CK-7; AltName: Full=Keratin-7; Short=K7; AltName: Full=Sarcolectin; AltName: Full=Type-II keratin Kb7;
FUNCTION: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
SUBUNIT: Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7.
INTERACTION: Q14152:EIF3A; NbExp=3; IntAct=EBI-297833, EBI-366617;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
INDUCTION: Up-regulated by retinoic acid.
PTM: Arg-20 is dimethylated, probably to asymmetric dimethylarginine.
MASS SPECTROMETRY: Mass=51203.48; Method=MALDI; Range=2-469; Source=PubMed:11840567;
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
SIMILARITY: Belongs to the intermediate filament family.
SEQUENCE CAUTION: Sequence=CAA26956.2; Type=Erroneous translation; Note=Wrong choice of CDS;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KRT7
Diseases sorted by gene-association score: pseudomyxoma peritonei (14), mucinous cystadenocarcinoma (9), signet ring cell adenocarcinoma (9), anal canal adenocarcinoma (8), appendix cancer (7), paget disease, extramammary (6), ovarian cancer, somatic (5), cervical adenocarcinoma (5), papillary carcinoma (5), transitional cell carcinoma (5), renal clear cell carcinoma (5), large cell carcinoma (5), mucoepidermoid carcinoma (5), proliferating trichilemmal cyst (5), teratoma (5), eccrine adenocarcinoma (5), chordoma (4), cystic basal cell carcinoma (4), chromophobe renal cell carcinoma (4), hepatocellular carcinoma (4), primary biliary cirrhosis (4), jejunal adenocarcinoma (4), endolymphatic sac tumor (4), hepatoblastoma (4), thymus cancer (4), renal cell carcinoma (4), cholangiocarcinoma, susceptibility to (4), basal cell carcinoma (4), adenoma (4), lipoadenoma (4), ovarian brenner tumor (4), necrotizing sialometaplasia (4), sarcoma, synovial (4), gallbladder signet ring cell adenocarcinoma (4), renal pelvis transitional cell carcinoma (4), colorectal adenocarcinoma (3), clear cell basal cell carcinoma (3), cystadenocarcinoma (3), bile duct carcinoma (3), pancreatic mucinous cystadenoma (3), intrahepatic cholangiocarcinoma (3), pulmonary hemosiderosis (3), secretory meningioma (3), mucinous bronchioloalveolar adenocarcinoma (3), vulva cancer (3), lung cancer susceptibility 3 (3), small cell carcinoma of the bladder (3), bladder urothelial carcinoma (3), clear cell papillary renal cell carcinoma (3), benign metastasizing leiomyoma (3), endometrial adenocarcinoma (3), barrett esophagus/esophageal adenocarcinoma (3), intestinal obstruction (3), nephrogenic adenoma of urinary bladder (3), lung cancer (3), endometrial cancer (3), mesothelioma, somatic (2), vulval paget's disease (2), papilloma (2), rectal neoplasm (2), inverted transitional papilloma (2), anal gland adenocarcinoma (2), vulva adenocarcinoma (2), granulosa cell tumor of the ovary (2), eccrine papillary adenocarcinoma (2), small cell cancer of the lung, somatic (2), horseshoe kidney (2), large intestine adenocarcinoma (2), lung acinar adenocarcinoma (2), wilms tumor susceptibility-5 (2), seminal vesicle adenocarcinoma (2), kidney benign neoplasm (2), cell type cancer (2), bladder benign neoplasm (2), mucinous adenofibroma (2), urinary bladder cancer (2), pancreatic cancer (2), stomach cancer (2), nodular hidradenoma (2), renal cell carcinoma, papillary (2), vulvar intraepithelial neoplasia (2), hidradenocarcinoma (2), cutaneous adenocystic carcinoma (2), primary cutaneous amyloidosis (2), malignant spiradenoma (2), cervical adenoma malignum (2), anus adenocarcinoma (2), balloon cell malignant melanoma (2), cutaneous mucoepidermoid carcinoma (2), anus basaloid carcinoma (2), bile duct adenocarcinoma (2), organ system benign neoplasm (2), ovarian mucinous neoplasm (2), extraosseous osteosarcoma (2), intrahepatic bile duct adenoma (2), renal pelvis carcinoma (2), intratubular embryonal carcinoma (2), bile duct mucoepidermoid carcinoma (2), integumentary system cancer (2), prostate squamous cell carcinoma (2), bile duct cystadenocarcinoma (2), large cell acanthoma (1), oncocytic breast carcinoma (1), cervical mucinous adenocarcinoma (1), biliary papillomatosis (1), cystitis cystica (1), ovary epithelial cancer (1), ovary adenocarcinoma (1), gastrointestinal system benign neoplasm (1), ovarian large-cell neuroendocrine carcinoma (1), colorectal cancer (1), adenoid basal cell carcinoma (1), malignant ovarian surface epithelial-stromal neoplasm (1), vaginal benign neoplasm (1), vaginal adenoma (1), vaginal tubulovillous adenoma (1), cecum adenocarcinoma (1), malignant leydig cell tumor (1), germ cell and embryonal cancer (1), epithelial predominant wilms' tumor (1), cell type benign neoplasm (1), cribriform carcinoma (1), meibomian cyst (1), bladder lymphoma (1), nasal cavity adenocarcinoma (1), vulvar sarcoma (1), glycogen-rich clear cell breast carcinoma (1), seminal vesicle tumor (1), nephrogenic adenofibroma (1), cystadenofibroma (1), choriocarcinoma of the testis (1), malignant biphasic mesothelioma (1), corneal abscess (1), pancreatic serous cystadenoma (1), ovarian endodermal sinus tumor (1), appendix adenocarcinoma (1), transverse colon cancer (1), breast adenoid cystic carcinoma (1), bladder carcinoma in situ (1), thymus adenocarcinoma (1), breast adenomyoepithelioma (1), breast myoepithelial neoplasm (1), ovarian primitive germ cell tumor (1), gastrointestinal system cancer (1), atypical choroid plexus papilloma (1), chondroid lipoma (1), nasal cavity squamous cell carcinoma (1), infiltrative basal cell carcinoma (1), adenosquamous pancreas carcinoma (1), mucinous ovarian cystadenoma (1), mucinous tubular and spindle renal cell carcinoma (1), malignant epithelial mesothelioma (1), immune system organ benign neoplasm (1), thymus lipoma (1), clear cell adenofibroma (1), renal-hepatic-pancreatic dysplasia (1), urethral diverticulum (1), gastric tubular adenocarcinoma (1), ovarian cystic teratoma (1), white sponge nevus 1 (1), intraneural perineurioma (1), breast secretory carcinoma (1), pericardium cancer (1), pericardial mesothelioma (1), leukocoria (1), spindle cell synovial sarcoma (1), skull base meningioma (1), leber congenital amaurosis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 363.80 RPKM in Minor Salivary Gland
Total median expression: 932.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.8054-0.293 Picture PostScript Text
3' UTR -30.70161-0.191 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016044 - F
IPR001664 - IF
IPR018039 - Intermediate_filament_CS
IPR003054 - Keratin_II
IPR009053 - Prefoldin

Pfam Domains:
PF00038 - Intermediate filament protein
PF01468 - GA module
PF16208 - Keratin type II head

SCOP Domains:
46579 - Prefoldin
58042 - Outer membrane lipoprotein
64593 - Intermediate filament protein, coiled coil region
90257 - Myosin rod fragments
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on P08729
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005515 protein binding

Biological Process:
GO:0016032 viral process
GO:0031424 keratinization
GO:0070268 cornification

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AJ238246 - Homo sapiens mRNA for sarcolectin.
LQ270770 - Sequence 98 from Patent WO2016071350.
AK128848 - Homo sapiens cDNA FLJ46620 fis, clone TLUNG2000654, highly similar to Keratin, type II cytoskeletal 7.
AK129924 - Homo sapiens cDNA FLJ26414 fis, clone KDN00245, highly similar to Keratin, type II cytoskeletal 7.
AK025881 - Homo sapiens cDNA: FLJ22228 fis, clone HRC01786, highly similar to HSKER7R Human mRNA fragment for mesothelial type II keratin K7.
AF509887 - Homo sapiens keratin 7 (KRT7) mRNA, complete cds.
X03212 - Human mRNA fragment for mesothelial type II keratin K7.
AK128505 - Homo sapiens cDNA FLJ46658 fis, clone TRACH3006379, moderately similar to Keratin, type II cytoskeletal 7.
AK225498 - Homo sapiens mRNA for keratin 7 variant, clone: JTH08659.
BC002700 - Homo sapiens keratin 7, mRNA (cDNA clone MGC:3625 IMAGE:3610347), complete cds.
DQ892996 - Synthetic construct clone IMAGE:100005626; FLH191501.01X; RZPDo839D1177D keratin 7 (KRT7) gene, encodes complete protein.
DQ896244 - Synthetic construct Homo sapiens clone IMAGE:100010704; FLH191497.01L; RZPDo839D1167D keratin 7 (KRT7) gene, encodes complete protein.
AB590146 - Synthetic construct DNA, clone: pFN21AB7993, Homo sapiens KRT7 gene for keratin 7, without stop codon, in Flexi system.
CU678130 - Synthetic construct Homo sapiens gateway clone IMAGE:100019548 5' read KRT7 mRNA.
KJ897111 - Synthetic construct Homo sapiens clone ccsbBroadEn_06505 KRT7 gene, encodes complete protein.
Z36852 - H.sapiens (xscad) mRNA, 340bp.
BC107082 - Homo sapiens keratin 7, mRNA (cDNA clone IMAGE:40014154), complete cds.
BC107083 - Homo sapiens keratin 7, mRNA (cDNA clone IMAGE:40014155), partial cds.
BC009521 - Homo sapiens, clone IMAGE:3638955, mRNA, partial cds.
JD049942 - Sequence 30966 from Patent EP1572962.
JD096014 - Sequence 77038 from Patent EP1572962.
JD349197 - Sequence 330221 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P08729 (Reactome details) participates in the following event(s):

R-HSA-6805546 Keratin type I binds keratin type II
R-HSA-6805573 Keratin type I/type II heterodimers form tetramers
R-HSA-6806613 Keratin tetramers bind to form unit length filaments
R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000331817.1, ENST00000331817.2, ENST00000331817.3, ENST00000331817.4, ENST00000331817.5, K2C7_HUMAN, NM_005556, P08729, Q92676, Q9BUD8, Q9Y3R7, SCL, uc317thn.1, uc317thn.2
UCSC ID: ENST00000331817.6_4
RefSeq Accession: NM_005556.4
Protein: P08729 (aka K2C7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.