ID:K2C72_HUMAN DESCRIPTION: RecName: Full=Keratin, type II cytoskeletal 72; AltName: Full=Cytokeratin-72; Short=CK-72; AltName: Full=Keratin-72; Short=K72; AltName: Full=Type II inner root sheath-specific keratin-K6irs2; AltName: Full=Type-II keratin Kb35; FUNCTION: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). SUBUNIT: Heterotetramer of two type I and two type II keratins. TISSUE SPECIFICITY: Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantar epidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of the dermal papilla (at protein level). MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40- 55 and 56-70 kDa, respectively). SIMILARITY: Belongs to the intermediate filament family. CAUTION: Was initially thought to be the ortholog of mouse KRT71 (PubMed:11703281). SEQUENCE CAUTION: Sequence=BAC04039.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00038 - Intermediate filament protein PF16208 - Keratin type II head
SCOP Domains: 46579 - Prefoldin 47661 - t-snare proteins 69754 - Ribosome binding protein Y (YfiA homologue) 64593 - Intermediate filament protein, coiled coil region 90257 - Myosin rod fragments 57997 - Tropomyosin
ModBase Predicted Comparative 3D Structure on Q14CN4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
