Human Gene KTN1 (ENST00000395314.8_7) from GENCODE V47lift37
  Description: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. (from UniProt Q86UP2)
Gencode Transcript: ENST00000395314.8_7
Gencode Gene: ENSG00000126777.18_14
Transcript (Including UTRs)
   Position: hg19 chr14:56,046,925-56,151,297 Size: 104,373 Total Exon Count: 44 Strand: +
Coding Region
   Position: hg19 chr14:56,078,767-56,150,821 Size: 72,055 Coding Exon Count: 43 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:56,046,925-56,151,297)mRNA (may differ from genome)Protein (1357 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCMGI
PubMedReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: KTN1_HUMAN
DESCRIPTION: RecName: Full=Kinectin; AltName: Full=CG-1 antigen; AltName: Full=Kinesin receptor;
FUNCTION: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
SUBUNIT: Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Vesicle membrane protein anchored to the endoplasmic reticulum.
TISSUE SPECIFICITY: High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.
SIMILARITY: Belongs to the kinectin family.
SEQUENCE CAUTION: Sequence=AAH50555.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA02794.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.88 RPKM in Muscle - Skeletal
Total median expression: 1532.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -84.10178-0.472 Picture PostScript Text
3' UTR -90.30476-0.190 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024854 - Kinectin

Pfam Domains:
PF05104 - Ribosome receptor lysine/proline rich region

ModBase Predicted Comparative 3D Structure on Q86UP2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019894 kinesin binding
GO:0045296 cadherin binding

Biological Process:
GO:0007018 microtubule-based movement
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF210034 - JP 2014500723-A/17537: Polycomb-Associated Non-Coding RNAs.
D13629 - Homo sapiens KIAA0004 mRNA.
AK302797 - Homo sapiens cDNA FLJ61494 complete cds, highly similar to Kinectin.
BC050555 - Homo sapiens kinectin 1 (kinesin receptor), mRNA (cDNA clone IMAGE:6059709), partial cds.
Z22551 - H.sapiens kinectin gene.
AY264265 - Homo sapiens kinectin variant 1 mRNA, complete cds.
BC112337 - Homo sapiens kinectin 1 (kinesin receptor), mRNA (cDNA clone MGC:133337 IMAGE:40068009), complete cds.
BC117132 - Homo sapiens kinectin 1 (kinesin receptor), mRNA (cDNA clone MGC:150741 IMAGE:40125683), complete cds.
BC143720 - Homo sapiens kinectin 1 (kinesin receptor), mRNA (cDNA clone MGC:177251 IMAGE:9052234), complete cds.
L25616 - Homo sapiens kinectin mRNA, complete cds.
HQ258602 - Synthetic construct Homo sapiens clone IMAGE:100073199 Unknown protein gene, encodes complete protein.
AB527439 - Synthetic construct DNA, clone: pF1KE1030, Homo sapiens KTN1 gene for kinectin 1, without stop codon, in Flexi system.
MA445611 - JP 2018138019-A/17537: Polycomb-Associated Non-Coding RNAs.
BC066337 - Homo sapiens kinectin 1 (kinesin receptor), mRNA (cDNA clone IMAGE:5302867), partial cds.
LF334193 - JP 2014500723-A/141696: Polycomb-Associated Non-Coding RNAs.
JC506661 - Sequence 29 from Patent EP2733220.
JC737773 - Sequence 29 from Patent WO2014075939.
JC506666 - Sequence 34 from Patent EP2733220.
JC737778 - Sequence 34 from Patent WO2014075939.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
BC058736 - Homo sapiens kinectin 1 (kinesin receptor), mRNA (cDNA clone IMAGE:6645668), partial cds.
BC104648 - Homo sapiens kinectin 1 (kinesin receptor), mRNA (cDNA clone IMAGE:6616516), partial cds.
LF334199 - JP 2014500723-A/141702: Polycomb-Associated Non-Coding RNAs.
LF334200 - JP 2014500723-A/141703: Polycomb-Associated Non-Coding RNAs.
LF334201 - JP 2014500723-A/141704: Polycomb-Associated Non-Coding RNAs.
LF334202 - JP 2014500723-A/141705: Polycomb-Associated Non-Coding RNAs.
LF334204 - JP 2014500723-A/141707: Polycomb-Associated Non-Coding RNAs.
LF334208 - JP 2014500723-A/141711: Polycomb-Associated Non-Coding RNAs.
LF334209 - JP 2014500723-A/141712: Polycomb-Associated Non-Coding RNAs.
LF334210 - JP 2014500723-A/141713: Polycomb-Associated Non-Coding RNAs.
MA569770 - JP 2018138019-A/141696: Polycomb-Associated Non-Coding RNAs.
MA569776 - JP 2018138019-A/141702: Polycomb-Associated Non-Coding RNAs.
MA569777 - JP 2018138019-A/141703: Polycomb-Associated Non-Coding RNAs.
MA569778 - JP 2018138019-A/141704: Polycomb-Associated Non-Coding RNAs.
MA569779 - JP 2018138019-A/141705: Polycomb-Associated Non-Coding RNAs.
MA569781 - JP 2018138019-A/141707: Polycomb-Associated Non-Coding RNAs.
MA569785 - JP 2018138019-A/141711: Polycomb-Associated Non-Coding RNAs.
MA569786 - JP 2018138019-A/141712: Polycomb-Associated Non-Coding RNAs.
MA569787 - JP 2018138019-A/141713: Polycomb-Associated Non-Coding RNAs.
LF334215 - JP 2014500723-A/141718: Polycomb-Associated Non-Coding RNAs.
LF334217 - JP 2014500723-A/141720: Polycomb-Associated Non-Coding RNAs.
AY536375 - Homo sapiens rhabdomyosarcoma antigen MU-RMS-40.19 mRNA, partial cds.
LF334219 - JP 2014500723-A/141722: Polycomb-Associated Non-Coding RNAs.
LF334221 - JP 2014500723-A/141724: Polycomb-Associated Non-Coding RNAs.
LF334222 - JP 2014500723-A/141725: Polycomb-Associated Non-Coding RNAs.
LF334224 - JP 2014500723-A/141727: Polycomb-Associated Non-Coding RNAs.
LF334225 - JP 2014500723-A/141728: Polycomb-Associated Non-Coding RNAs.
AK308272 - Homo sapiens cDNA, FLJ98220.
LF334228 - JP 2014500723-A/141731: Polycomb-Associated Non-Coding RNAs.
LF334229 - JP 2014500723-A/141732: Polycomb-Associated Non-Coding RNAs.
LF334230 - JP 2014500723-A/141733: Polycomb-Associated Non-Coding RNAs.
LF334231 - JP 2014500723-A/141734: Polycomb-Associated Non-Coding RNAs.
LF334232 - JP 2014500723-A/141735: Polycomb-Associated Non-Coding RNAs.
LF334233 - JP 2014500723-A/141736: Polycomb-Associated Non-Coding RNAs.
AK300703 - Homo sapiens cDNA FLJ55573 complete cds, highly similar to Kinectin.
LF334236 - JP 2014500723-A/141739: Polycomb-Associated Non-Coding RNAs.
AK125499 - Homo sapiens cDNA FLJ43510 fis, clone PERIC2003720, highly similar to Kinectin.
LF334242 - JP 2014500723-A/141745: Polycomb-Associated Non-Coding RNAs.
AK055870 - Homo sapiens cDNA FLJ31308 fis, clone LIVER1000139, highly similar to Kinectin.
LF334244 - JP 2014500723-A/141747: Polycomb-Associated Non-Coding RNAs.
BX537639 - Homo sapiens mRNA; cDNA DKFZp686M10116 (from clone DKFZp686M10116).
LF334245 - JP 2014500723-A/141748: Polycomb-Associated Non-Coding RNAs.
LF334246 - JP 2014500723-A/141749: Polycomb-Associated Non-Coding RNAs.
AK309840 - Homo sapiens cDNA, FLJ99881.
LF334248 - JP 2014500723-A/141751: Polycomb-Associated Non-Coding RNAs.
LF334249 - JP 2014500723-A/141752: Polycomb-Associated Non-Coding RNAs.
AK124180 - Homo sapiens cDNA FLJ42186 fis, clone THYMU2032155.
BX537523 - Homo sapiens mRNA; cDNA DKFZp686L034 (from clone DKFZp686L034).
LF334250 - JP 2014500723-A/141753: Polycomb-Associated Non-Coding RNAs.
LF334252 - JP 2014500723-A/141755: Polycomb-Associated Non-Coding RNAs.
LF334255 - JP 2014500723-A/141758: Polycomb-Associated Non-Coding RNAs.
JD025890 - Sequence 6914 from Patent EP1572962.
AJ270687 - Homo sapiens partial unknown mRNA from drug-resistant melanoma cells, 3'UTR, clone DSM-3.
LF334257 - JP 2014500723-A/141760: Polycomb-Associated Non-Coding RNAs.
JD034491 - Sequence 15515 from Patent EP1572962.
JD224058 - Sequence 205082 from Patent EP1572962.
JD296925 - Sequence 277949 from Patent EP1572962.
LF334258 - JP 2014500723-A/141761: Polycomb-Associated Non-Coding RNAs.
JD359543 - Sequence 340567 from Patent EP1572962.
JD300797 - Sequence 281821 from Patent EP1572962.
JD276844 - Sequence 257868 from Patent EP1572962.
JD469270 - Sequence 450294 from Patent EP1572962.
MA569792 - JP 2018138019-A/141718: Polycomb-Associated Non-Coding RNAs.
MA569794 - JP 2018138019-A/141720: Polycomb-Associated Non-Coding RNAs.
MA569796 - JP 2018138019-A/141722: Polycomb-Associated Non-Coding RNAs.
MA569798 - JP 2018138019-A/141724: Polycomb-Associated Non-Coding RNAs.
MA569799 - JP 2018138019-A/141725: Polycomb-Associated Non-Coding RNAs.
MA569801 - JP 2018138019-A/141727: Polycomb-Associated Non-Coding RNAs.
MA569802 - JP 2018138019-A/141728: Polycomb-Associated Non-Coding RNAs.
MA569805 - JP 2018138019-A/141731: Polycomb-Associated Non-Coding RNAs.
MA569806 - JP 2018138019-A/141732: Polycomb-Associated Non-Coding RNAs.
MA569807 - JP 2018138019-A/141733: Polycomb-Associated Non-Coding RNAs.
MA569808 - JP 2018138019-A/141734: Polycomb-Associated Non-Coding RNAs.
MA569809 - JP 2018138019-A/141735: Polycomb-Associated Non-Coding RNAs.
MA569810 - JP 2018138019-A/141736: Polycomb-Associated Non-Coding RNAs.
MA569813 - JP 2018138019-A/141739: Polycomb-Associated Non-Coding RNAs.
MA569819 - JP 2018138019-A/141745: Polycomb-Associated Non-Coding RNAs.
MA569821 - JP 2018138019-A/141747: Polycomb-Associated Non-Coding RNAs.
MA569822 - JP 2018138019-A/141748: Polycomb-Associated Non-Coding RNAs.
MA569823 - JP 2018138019-A/141749: Polycomb-Associated Non-Coding RNAs.
MA569825 - JP 2018138019-A/141751: Polycomb-Associated Non-Coding RNAs.
MA569826 - JP 2018138019-A/141752: Polycomb-Associated Non-Coding RNAs.
MA569827 - JP 2018138019-A/141753: Polycomb-Associated Non-Coding RNAs.
MA569829 - JP 2018138019-A/141755: Polycomb-Associated Non-Coding RNAs.
MA569832 - JP 2018138019-A/141758: Polycomb-Associated Non-Coding RNAs.
MA569834 - JP 2018138019-A/141760: Polycomb-Associated Non-Coding RNAs.
MA569835 - JP 2018138019-A/141761: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86UP2 (Reactome details) participates in the following event(s):

R-HSA-5625959 Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
R-HSA-5672083 KTN1 binds Kinesin-1
R-HSA-8952289 FAM20C phosphorylates FAM20C substrates
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-195258 RHO GTPase Effectors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-194315 Signaling by Rho GTPases
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B4DZ88, CG1, ENST00000395314.1, ENST00000395314.2, ENST00000395314.3, ENST00000395314.4, ENST00000395314.5, ENST00000395314.6, ENST00000395314.7, KIAA0004, KTN1_HUMAN, NR_175290, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57, uc318xht.1, uc318xht.2
UCSC ID: ENST00000395314.8_7
RefSeq Accession: NM_001079521.2
Protein: Q86UP2 (aka KTN1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.