Human Gene LACTB (ENST00000261893.9_4) from GENCODE V47lift37
  Description: lactamase beta, transcript variant 1 (from RefSeq NM_032857.5)
Gencode Transcript: ENST00000261893.9_4
Gencode Gene: ENSG00000103642.12_8
Transcript (Including UTRs)
   Position: hg19 chr15:63,414,060-63,434,260 Size: 20,201 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr15:63,414,071-63,434,004 Size: 19,934 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:63,414,060-63,434,260)mRNA (may differ from genome)Protein (547 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LACTB_HUMAN
DESCRIPTION: RecName: Full=Serine beta-lactamase-like protein LACTB, mitochondrial; EC=3.4.-.-; Flags: Precursor;
SUBCELLULAR LOCATION: Mitochondrion.
TISSUE SPECIFICITY: Expressed predominantly in skeletal muscle.
SIMILARITY: Belongs to the peptidase S12 family.
CAUTION: Was originally (PubMed:11551941) identified as 39S ribosomal protein L56 (MRP-L56).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LACTB
Diseases sorted by gene-association score: lung abscess (19), otitis media (5), mycobacterium fortuitum (4), gastroenteritis (4), meningitis (3), pneumonia (3), salmonellosis (3), endocarditis (3), cellulitis (2), autoinflammation with infantile enterocolitis (1), neisseria meningitidis infection (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.52 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 288.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -37.50256-0.146 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001466 - Beta-lactam-related
IPR012338 - Beta-lactam/transpept-like

Pfam Domains:
PF00144 - Beta-lactamase

SCOP Domains:
56601 - beta-lactamase/transpeptidase-like

ModBase Predicted Comparative 3D Structure on P83111
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008233 peptidase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding

Biological Process:
GO:0006508 proteolysis
GO:0006629 lipid metabolic process
GO:0019216 regulation of lipid metabolic process

Cellular Component:
GO:0005739 mitochondrion
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  KJ895262 - Synthetic construct Homo sapiens clone ccsbBroadEn_04656 LACTB gene, encodes complete protein.
BC067288 - Homo sapiens lactamase, beta, mRNA (cDNA clone MGC:75417 IMAGE:30366453), complete cds.
AK027808 - Homo sapiens cDNA FLJ14902 fis, clone PLACE1005467.
AY358709 - Homo sapiens clone DNA76522 MRPL56 (UNQ843) mRNA, complete cds.
BC037198 - Homo sapiens lactamase, beta, mRNA (cDNA clone IMAGE:4780106), containing frame-shift errors.
JD021581 - Sequence 2605 from Patent EP1572962.
JD033801 - Sequence 14825 from Patent EP1572962.
JD020999 - Sequence 2023 from Patent EP1572962.
JD032778 - Sequence 13802 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000261893.1, ENST00000261893.2, ENST00000261893.3, ENST00000261893.4, ENST00000261893.5, ENST00000261893.6, ENST00000261893.7, ENST00000261893.8, LACTB , LACTB_HUMAN, MRPL56 , NM_032857, P83096, P83111, uc317gvd.1, uc317gvd.2, UNQ843/PRO1781
UCSC ID: ENST00000261893.9_4
RefSeq Accession: NM_032857.5
Protein: P83111 (aka LACTB_HUMAN or LACB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.