Human Gene LAMB1 (ENST00000222399.11_7) from GENCODE V47lift37
  Description: laminin subunit beta 1 (from RefSeq NM_002291.3)
Gencode Transcript: ENST00000222399.11_7
Gencode Gene: ENSG00000091136.15_11
Transcript (Including UTRs)
   Position: hg19 chr7:107,564,244-107,643,606 Size: 79,363 Total Exon Count: 34 Strand: -
Coding Region
   Position: hg19 chr7:107,564,396-107,643,330 Size: 78,935 Coding Exon Count: 33 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:107,564,244-107,643,606)mRNA (may differ from genome)Protein (1786 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LAMB1_HUMAN
DESCRIPTION: RecName: Full=Laminin subunit beta-1; AltName: Full=Laminin B1 chain; AltName: Full=Laminin-1 subunit beta; AltName: Full=Laminin-10 subunit beta; AltName: Full=Laminin-12 subunit beta; AltName: Full=Laminin-2 subunit beta; AltName: Full=Laminin-6 subunit beta; AltName: Full=Laminin-8 subunit beta; Flags: Precursor;
FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-6 (laminin- 311 or K-laminin), laminin-8 (laminin-411), laminin-10 (laminin- 511) and laminin-12 (laminin-213).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
DOMAIN: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
DOMAIN: Domains VI and IV are globular.
SIMILARITY: Contains 13 laminin EGF-like domains.
SIMILARITY: Contains 1 laminin IV type B domain.
SIMILARITY: Contains 1 laminin N-terminal domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LAMB1
Diseases sorted by gene-association score: lissencephaly 5* (1368), pierson syndrome (17), teratocarcinoma (16), subcortical band heterotopia (10), band heterotopia (8), myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency (7), anthracosis (7), diffuse mesangial sclerosis (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 150.49 RPKM in Cells - Cultured fibroblasts
Total median expression: 1510.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.40137-0.412 Picture PostScript Text
3' UTR -18.30152-0.120 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002049 - EGF_laminin
IPR013015 - Laminin_IV
IPR008211 - Laminin_N
IPR009053 - Prefoldin

Pfam Domains:
PF00053 - Laminin EGF domain
PF00055 - Laminin N-terminal (Domain VI)

SCOP Domains:
46579 - Prefoldin
49785 - Galactose-binding domain-like
57196 - EGF/Laminin
57997 - Tropomyosin
58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain

ModBase Predicted Comparative 3D Structure on P07942
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding

Biological Process:
GO:0007155 cell adhesion
GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031175 neuron projection development
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035987 endodermal cell differentiation
GO:0042476 odontogenesis
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050679 positive regulation of epithelial cell proliferation

Cellular Component:
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005606 laminin-1 complex
GO:0005607 laminin-2 complex
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0031012 extracellular matrix
GO:0043257 laminin-8 complex
GO:0043259 laminin-10 complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF209508 - JP 2014500723-A/17011: Polycomb-Associated Non-Coding RNAs.
BX648251 - Homo sapiens mRNA; cDNA DKFZp686N12115 (from clone DKFZp686N12115).
M61916 - Human laminin B1 chain mRNA, complete cds.
BC113455 - Homo sapiens laminin, beta 1, mRNA (cDNA clone MGC:142015 IMAGE:8322507), complete cds.
AB384752 - Synthetic construct DNA, clone: pF1KB3109, Homo sapiens LAMB1 gene for laminin subunit beta-1 precursor, complete cds, without stop codon, in Flexi system.
AK307611 - Homo sapiens cDNA, FLJ97559.
AK309921 - Homo sapiens cDNA, FLJ99962.
AK303501 - Homo sapiens cDNA FLJ52150 complete cds, moderately similar to Laminin beta-1 chain precursor.
BC044633 - Homo sapiens laminin, beta 1, mRNA (cDNA clone IMAGE:4889995), containing frame-shift errors.
BC052598 - Homo sapiens cDNA clone IMAGE:4135495, containing frame-shift errors.
MA445085 - JP 2018138019-A/17011: Polycomb-Associated Non-Coding RNAs.
BC026018 - Homo sapiens laminin, beta 1, mRNA (cDNA clone IMAGE:3530032), partial cds.
LF329180 - JP 2014500723-A/136683: Polycomb-Associated Non-Coding RNAs.
LF329179 - JP 2014500723-A/136682: Polycomb-Associated Non-Coding RNAs.
LF329178 - JP 2014500723-A/136681: Polycomb-Associated Non-Coding RNAs.
E01259 - Part of cDNA encoding human laminin beta 1 chain.
M20206 - Human laminin B1 mRNA, complete cds.
LF329177 - JP 2014500723-A/136680: Polycomb-Associated Non-Coding RNAs.
LF329176 - JP 2014500723-A/136679: Polycomb-Associated Non-Coding RNAs.
LF329175 - JP 2014500723-A/136678: Polycomb-Associated Non-Coding RNAs.
LF329174 - JP 2014500723-A/136677: Polycomb-Associated Non-Coding RNAs.
LF329173 - JP 2014500723-A/136676: Polycomb-Associated Non-Coding RNAs.
LF329172 - JP 2014500723-A/136675: Polycomb-Associated Non-Coding RNAs.
LF329171 - JP 2014500723-A/136674: Polycomb-Associated Non-Coding RNAs.
LF329170 - JP 2014500723-A/136673: Polycomb-Associated Non-Coding RNAs.
LF329169 - JP 2014500723-A/136672: Polycomb-Associated Non-Coding RNAs.
LF329168 - JP 2014500723-A/136671: Polycomb-Associated Non-Coding RNAs.
LF329167 - JP 2014500723-A/136670: Polycomb-Associated Non-Coding RNAs.
LF329166 - JP 2014500723-A/136669: Polycomb-Associated Non-Coding RNAs.
E02610 - DNA encoding a part of human laminin B1 chain.
LF329165 - JP 2014500723-A/136668: Polycomb-Associated Non-Coding RNAs.
LF329164 - JP 2014500723-A/136667: Polycomb-Associated Non-Coding RNAs.
LF329162 - JP 2014500723-A/136665: Polycomb-Associated Non-Coding RNAs.
LF329161 - JP 2014500723-A/136664: Polycomb-Associated Non-Coding RNAs.
LF329160 - JP 2014500723-A/136663: Polycomb-Associated Non-Coding RNAs.
DQ577005 - Homo sapiens piRNA piR-45117, complete sequence.
LF329158 - JP 2014500723-A/136661: Polycomb-Associated Non-Coding RNAs.
LF329157 - JP 2014500723-A/136660: Polycomb-Associated Non-Coding RNAs.
LF329156 - JP 2014500723-A/136659: Polycomb-Associated Non-Coding RNAs.
LF329155 - JP 2014500723-A/136658: Polycomb-Associated Non-Coding RNAs.
LF329154 - JP 2014500723-A/136657: Polycomb-Associated Non-Coding RNAs.
LF329153 - JP 2014500723-A/136656: Polycomb-Associated Non-Coding RNAs.
LF329151 - JP 2014500723-A/136654: Polycomb-Associated Non-Coding RNAs.
MA564757 - JP 2018138019-A/136683: Polycomb-Associated Non-Coding RNAs.
MA564756 - JP 2018138019-A/136682: Polycomb-Associated Non-Coding RNAs.
MA564755 - JP 2018138019-A/136681: Polycomb-Associated Non-Coding RNAs.
MA564754 - JP 2018138019-A/136680: Polycomb-Associated Non-Coding RNAs.
MA564753 - JP 2018138019-A/136679: Polycomb-Associated Non-Coding RNAs.
MA564752 - JP 2018138019-A/136678: Polycomb-Associated Non-Coding RNAs.
MA564751 - JP 2018138019-A/136677: Polycomb-Associated Non-Coding RNAs.
MA564750 - JP 2018138019-A/136676: Polycomb-Associated Non-Coding RNAs.
MA564749 - JP 2018138019-A/136675: Polycomb-Associated Non-Coding RNAs.
MA564748 - JP 2018138019-A/136674: Polycomb-Associated Non-Coding RNAs.
MA564747 - JP 2018138019-A/136673: Polycomb-Associated Non-Coding RNAs.
MA564746 - JP 2018138019-A/136672: Polycomb-Associated Non-Coding RNAs.
MA564745 - JP 2018138019-A/136671: Polycomb-Associated Non-Coding RNAs.
MA564744 - JP 2018138019-A/136670: Polycomb-Associated Non-Coding RNAs.
MA564743 - JP 2018138019-A/136669: Polycomb-Associated Non-Coding RNAs.
MA564742 - JP 2018138019-A/136668: Polycomb-Associated Non-Coding RNAs.
MA564741 - JP 2018138019-A/136667: Polycomb-Associated Non-Coding RNAs.
MA564739 - JP 2018138019-A/136665: Polycomb-Associated Non-Coding RNAs.
MA564738 - JP 2018138019-A/136664: Polycomb-Associated Non-Coding RNAs.
MA564737 - JP 2018138019-A/136663: Polycomb-Associated Non-Coding RNAs.
MA564735 - JP 2018138019-A/136661: Polycomb-Associated Non-Coding RNAs.
MA564734 - JP 2018138019-A/136660: Polycomb-Associated Non-Coding RNAs.
MA564733 - JP 2018138019-A/136659: Polycomb-Associated Non-Coding RNAs.
MA564732 - JP 2018138019-A/136658: Polycomb-Associated Non-Coding RNAs.
MA564731 - JP 2018138019-A/136657: Polycomb-Associated Non-Coding RNAs.
MA564730 - JP 2018138019-A/136656: Polycomb-Associated Non-Coding RNAs.
MA564728 - JP 2018138019-A/136654: Polycomb-Associated Non-Coding RNAs.
LF329149 - JP 2014500723-A/136652: Polycomb-Associated Non-Coding RNAs.
LF329148 - JP 2014500723-A/136651: Polycomb-Associated Non-Coding RNAs.
LF329147 - JP 2014500723-A/136650: Polycomb-Associated Non-Coding RNAs.
LF329146 - JP 2014500723-A/136649: Polycomb-Associated Non-Coding RNAs.
LF329145 - JP 2014500723-A/136648: Polycomb-Associated Non-Coding RNAs.
LF329144 - JP 2014500723-A/136647: Polycomb-Associated Non-Coding RNAs.
LF329142 - JP 2014500723-A/136645: Polycomb-Associated Non-Coding RNAs.
LF329141 - JP 2014500723-A/136644: Polycomb-Associated Non-Coding RNAs.
LF329137 - JP 2014500723-A/136640: Polycomb-Associated Non-Coding RNAs.
LF329136 - JP 2014500723-A/136639: Polycomb-Associated Non-Coding RNAs.
LF212484 - JP 2014500723-A/19987: Polycomb-Associated Non-Coding RNAs.
LF213284 - JP 2014500723-A/20787: Polycomb-Associated Non-Coding RNAs.
LF329135 - JP 2014500723-A/136638: Polycomb-Associated Non-Coding RNAs.
JD211406 - Sequence 192430 from Patent EP1572962.
JD042435 - Sequence 23459 from Patent EP1572962.
JD394163 - Sequence 375187 from Patent EP1572962.
MA564726 - JP 2018138019-A/136652: Polycomb-Associated Non-Coding RNAs.
MA564725 - JP 2018138019-A/136651: Polycomb-Associated Non-Coding RNAs.
MA564724 - JP 2018138019-A/136650: Polycomb-Associated Non-Coding RNAs.
MA564723 - JP 2018138019-A/136649: Polycomb-Associated Non-Coding RNAs.
MA564722 - JP 2018138019-A/136648: Polycomb-Associated Non-Coding RNAs.
MA564721 - JP 2018138019-A/136647: Polycomb-Associated Non-Coding RNAs.
MA564719 - JP 2018138019-A/136645: Polycomb-Associated Non-Coding RNAs.
MA564718 - JP 2018138019-A/136644: Polycomb-Associated Non-Coding RNAs.
MA564714 - JP 2018138019-A/136640: Polycomb-Associated Non-Coding RNAs.
MA564713 - JP 2018138019-A/136639: Polycomb-Associated Non-Coding RNAs.
MA564712 - JP 2018138019-A/136638: Polycomb-Associated Non-Coding RNAs.
MA448061 - JP 2018138019-A/19987: Polycomb-Associated Non-Coding RNAs.
MA448861 - JP 2018138019-A/20787: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_prionPathway - Prion Pathway

Reactome (by CSHL, EBI, and GO)

Protein P07942 (Reactome details) participates in the following event(s):

R-HSA-216051 Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111
R-HSA-443778 Interaction of L1 with Laminin-1
R-HSA-2328145 Laminin-111 binds collagen type IV
R-HSA-4084507 Laminin-111 binds endostatin dimer
R-HSA-2533874 Laminin-511 degradation by MMP14
R-HSA-2328129 Dystroglycan binds Laminins and Dystrophin
R-HSA-2396083 Laminins bind galactosyl sulfatide and related sulfated glycolipids
R-HSA-2327803 Laminins bind Nidogens 1, 2
R-HSA-2426355 NTN4 binds laminins with gamma-1, gamma-3
R-HSA-2396124 AGRN binds Laminins with gamma-1 subunit
R-HSA-4084505 Laminins bind HSPG2
R-HSA-216058 Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521
R-HSA-3907292 Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411
R-HSA-216048 Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)
R-HSA-8952289 FAM20C phosphorylates FAM20C substrates
R-HSA-2426450 Laminins:Nidogens binds collagen type IV networks
R-HSA-2426530 Laminins:Nidogens binds HSPG2
R-HSA-3000157 Laminin interactions
R-HSA-373760 L1CAM interactions
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-1474244 Extracellular matrix organization
R-HSA-422475 Axon guidance
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-1266738 Developmental Biology
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000222399.1, ENST00000222399.10, ENST00000222399.2, ENST00000222399.3, ENST00000222399.4, ENST00000222399.5, ENST00000222399.6, ENST00000222399.7, ENST00000222399.8, ENST00000222399.9, LAMB1_HUMAN, NM_002291, P07942, Q14D91, uc317deu.1, uc317deu.2
UCSC ID: ENST00000222399.11_7
RefSeq Accession: NM_002291.3
Protein: P07942 (aka LAMB1_HUMAN or LMB1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.