ID:LTOR5_HUMAN DESCRIPTION: RecName: Full=Ragulator complex protein LAMTOR5; AltName: Full=Hepatitis B virus X-interacting protein; Short=HBV X-interacting protein; Short=HBX-interacting protein; AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5; FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. SUBUNIT: Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form an heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus. SUBCELLULAR LOCATION: Cytoplasm. Lysosome. TISSUE SPECIFICITY: Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX. SIMILARITY: Belongs to the LAMTOR5 family. SEQUENCE CAUTION: Sequence=AAH62619.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43504
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0005085 guanyl-nucleotide exchange factor activity GO:0032947 protein complex scaffold
Biological Process: GO:0007050 cell cycle arrest GO:0008361 regulation of cell size GO:0009615 response to virus GO:0016241 regulation of macroautophagy GO:0019079 viral genome replication GO:0032008 positive regulation of TOR signaling GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0061462 protein localization to lysosome GO:0071230 cellular response to amino acid stimulus
JD160629 - Sequence 141653 from Patent EP1572962. JD466980 - Sequence 448004 from Patent EP1572962. AF029890 - Homo sapiens hepatitis B virus X interacting protein (XIP) mRNA, complete cds. BC062619 - Homo sapiens hepatitis B virus x interacting protein, mRNA (cDNA clone MGC:71071 IMAGE:5190406), complete cds. AK056679 - Homo sapiens cDNA FLJ32117 fis, clone PANCR1000185. AK054769 - Homo sapiens cDNA FLJ30207 fis, clone BRACE2001534, moderately similar to HEPATITIS B VIRUS X INTERACTING PROTEIN. JD564128 - Sequence 545152 from Patent EP1572962. JD551290 - Sequence 532314 from Patent EP1572962. JD113001 - Sequence 94025 from Patent EP1572962. JD250320 - Sequence 231344 from Patent EP1572962. JD182344 - Sequence 163368 from Patent EP1572962. JD113148 - Sequence 94172 from Patent EP1572962. JD506917 - Sequence 487941 from Patent EP1572962. JD550059 - Sequence 531083 from Patent EP1572962. AY623819 - Homo sapiens hepatitis B virus x interacting protein (HBXIP) mRNA, complete cds. HQ257924 - Synthetic construct Homo sapiens clone IMAGE:100072233 hepatitis B virus x interacting protein (HBXIP) gene, encodes complete protein. KJ893068 - Synthetic construct Homo sapiens clone ccsbBroadEn_02462 HBXIP gene, encodes complete protein. CR456866 - Homo sapiens full open reading frame cDNA clone RZPDo834H0615D for gene HBXIP, hepatitis B virus x interacting protein; complete cds, incl. stopcodon. CR542130 - Homo sapiens full open reading frame cDNA clone RZPDo834D1123D for gene HBXIP, hepatitis B virus x interacting protein; complete cds, without stopcodon.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus
Reactome (by CSHL, EBI, and GO)
Protein O43504 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
