Human Gene LANCL1 (ENST00000450366.7_8) from GENCODE V47lift37
  Description: LanC like 1, transcript variant 1 (from RefSeq NM_006055.3)
Gencode Transcript: ENST00000450366.7_8
Gencode Gene: ENSG00000115365.13_11
Transcript (Including UTRs)
   Position: hg19 chr2:211,295,975-211,341,483 Size: 45,509 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr2:211,299,211-211,341,120 Size: 41,910 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:211,295,975-211,341,483)mRNA (may differ from genome)Protein (399 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 81.48 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 970.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.50156-0.433 Picture PostScript Text
3' UTR -778.013236-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008928 - 6-hairpin_glycosidase-like
IPR012341 - 6hp_glycosidase
IPR007822 - LANC-like
IPR020464 - LanC-like_prot_euk

Pfam Domains:
PF05147 - Lanthionine synthetase C-like protein

SCOP Domains:
48208 - Six-hairpin glycosidases
48225 - Seven-hairpin glycosidases
158745 - LanC-like
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes

ModBase Predicted Comparative 3D Structure on Q53TN2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity


-  Descriptions from all associated GenBank mRNAs
  Y11395 - Homo sapiens mRNA for lanthionine synthetase C-like protein 1 (LANCL1 gene).
JD490708 - Sequence 471732 from Patent EP1572962.
JD277419 - Sequence 258443 from Patent EP1572962.
JD276702 - Sequence 257726 from Patent EP1572962.
JD147290 - Sequence 128314 from Patent EP1572962.
JD280549 - Sequence 261573 from Patent EP1572962.
JD296537 - Sequence 277561 from Patent EP1572962.
JD167557 - Sequence 148581 from Patent EP1572962.
JD304523 - Sequence 285547 from Patent EP1572962.
JD056926 - Sequence 37950 from Patent EP1572962.
JD442079 - Sequence 423103 from Patent EP1572962.
JD250273 - Sequence 231297 from Patent EP1572962.
JD282862 - Sequence 263886 from Patent EP1572962.
JD078584 - Sequence 59608 from Patent EP1572962.
JD245937 - Sequence 226961 from Patent EP1572962.
JD412536 - Sequence 393560 from Patent EP1572962.
JD433843 - Sequence 414867 from Patent EP1572962.
JD096658 - Sequence 77682 from Patent EP1572962.
JD098913 - Sequence 79937 from Patent EP1572962.
JD490129 - Sequence 471153 from Patent EP1572962.
JD466702 - Sequence 447726 from Patent EP1572962.
JD561507 - Sequence 542531 from Patent EP1572962.
JD372185 - Sequence 353209 from Patent EP1572962.
JD323719 - Sequence 304743 from Patent EP1572962.
JD202781 - Sequence 183805 from Patent EP1572962.
BC007041 - Homo sapiens cDNA clone IMAGE:3826223, containing frame-shift errors.
JD060117 - Sequence 41141 from Patent EP1572962.
JD441364 - Sequence 422388 from Patent EP1572962.
JD363566 - Sequence 344590 from Patent EP1572962.
JD237786 - Sequence 218810 from Patent EP1572962.
JD562501 - Sequence 543525 from Patent EP1572962.
JD375497 - Sequence 356521 from Patent EP1572962.
JD088712 - Sequence 69736 from Patent EP1572962.
AK294674 - Homo sapiens cDNA FLJ51489 complete cds, highly similar to LanC-like protein 1.
JD305851 - Sequence 286875 from Patent EP1572962.
JD554197 - Sequence 535221 from Patent EP1572962.
JD039174 - Sequence 20198 from Patent EP1572962.
BC028685 - Homo sapiens LanC lantibiotic synthetase component C-like 1 (bacterial), mRNA (cDNA clone MGC:26280 IMAGE:4829574), complete cds.
JD428120 - Sequence 409144 from Patent EP1572962.
AK309295 - Homo sapiens cDNA, FLJ99336.
AK309088 - Homo sapiens cDNA, FLJ99129.
JD358695 - Sequence 339719 from Patent EP1572962.
AK312381 - Homo sapiens cDNA, FLJ92709, highly similar to Homo sapiens LanC lantibiotic synthetase component C-like 1 (bacterial) (LANCL1), mRNA.
KJ893004 - Synthetic construct Homo sapiens clone ccsbBroadEn_02398 LANCL1 gene, encodes complete protein.
DQ893780 - Synthetic construct Homo sapiens clone IMAGE:100008240; FLH167502.01L; RZPDo839B0789D LanC lantibiotic synthetase component C-like 1 (bacterial) (LANCL1) gene, encodes complete protein.
CR541777 - Homo sapiens full open reading frame cDNA clone RZPDo834E0130D for gene LANCL1, LanC lantibiotic synthetase component C-like 1 (bacterial); complete cds, without stopcodon.
JD395847 - Sequence 376871 from Patent EP1572962.
JD339245 - Sequence 320269 from Patent EP1572962.
JD440639 - Sequence 421663 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R453, ENST00000450366.1, ENST00000450366.2, ENST00000450366.3, ENST00000450366.4, ENST00000450366.5, ENST00000450366.6, hCG_16716 , LANCL1 , NM_006055, Q53TN2, Q53TN2_HUMAN, uc320ruk.1, uc320ruk.2
UCSC ID: ENST00000450366.7_8
RefSeq Accession: NM_006055.3
Protein: Q53TN2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.