ID:LBX1_HUMAN DESCRIPTION: RecName: Full=Transcription factor LBX1; AltName: Full=Ladybird homeobox protein homolog 1; FUNCTION: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord (By similarity). SUBUNIT: Interacts with SKOR1 which acts as a transcriptional corepressor (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 46689 - Homeodomain-like 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
ModBase Predicted Comparative 3D Structure on P52954
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.