ID:LEP_HUMAN DESCRIPTION: RecName: Full=Leptin; AltName: Full=Obese protein; AltName: Full=Obesity factor; Flags: Precursor; FUNCTION: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. SUBUNIT: Interacts with SIGLEC6. SUBCELLULAR LOCATION: Secreted. DISEASE: Defects in LEP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. SIMILARITY: Belongs to the leptin family. WEB RESOURCE: Name=R&D Systems' cytokine mini-reviews: Leptin; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1773"; WEB RESOURCE: Name=Wikipedia; Note=Leptin entry; URL="http://en.wikipedia.org/wiki/Leptin"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/lep/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41159
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001525 angiogenesis GO:0001542 ovulation from ovarian follicle GO:0001666 response to hypoxia GO:0001819 positive regulation of cytokine production GO:0001890 placenta development GO:0001932 regulation of protein phosphorylation GO:0001936 regulation of endothelial cell proliferation GO:0002021 response to dietary excess GO:0003300 cardiac muscle hypertrophy GO:0006006 glucose metabolic process GO:0006111 regulation of gluconeogenesis GO:0006112 energy reserve metabolic process GO:0006114 glycerol biosynthetic process GO:0006629 lipid metabolic process GO:0006635 fatty acid beta-oxidation GO:0006909 phagocytosis GO:0007165 signal transduction GO:0007260 tyrosine phosphorylation of STAT protein GO:0007565 female pregnancy GO:0007584 response to nutrient GO:0007623 circadian rhythm GO:0008203 cholesterol metabolic process GO:0008206 bile acid metabolic process GO:0008217 regulation of blood pressure GO:0008284 positive regulation of cell proliferation GO:0008343 adult feeding behavior GO:0009062 fatty acid catabolic process GO:0009892 negative regulation of metabolic process GO:0010469 regulation of receptor activity GO:0010507 negative regulation of autophagy GO:0010888 negative regulation of lipid storage GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014823 response to activity GO:0019222 regulation of metabolic process GO:0019953 sexual reproduction GO:0021954 central nervous system neuron development GO:0030073 insulin secretion GO:0030217 T cell differentiation GO:0030300 regulation of intestinal cholesterol absorption GO:0031667 response to nutrient levels GO:0032008 positive regulation of TOR signaling GO:0032099 negative regulation of appetite GO:0032310 prostaglandin secretion GO:0032355 response to estradiol GO:0032615 interleukin-12 production GO:0032635 interleukin-6 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032814 regulation of natural killer cell activation GO:0032817 regulation of natural killer cell proliferation GO:0032868 response to insulin GO:0033197 response to vitamin E GO:0033210 leptin-mediated signaling pathway GO:0033686 positive regulation of luteinizing hormone secretion GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway GO:0035556 intracellular signal transduction GO:0035630 bone mineralization involved in bone maturation GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway GO:0042102 positive regulation of T cell proliferation GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0042307 positive regulation of protein import into nucleus GO:0042445 hormone metabolic process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042593 glucose homeostasis GO:0042755 eating behavior GO:0043066 negative regulation of apoptotic process GO:0043270 positive regulation of ion transport GO:0043410 positive regulation of MAPK cascade GO:0044320 cellular response to leptin stimulus GO:0045471 response to ethanol GO:0045598 regulation of fat cell differentiation GO:0045765 regulation of angiogenesis GO:0045906 negative regulation of vasoconstriction GO:0046325 negative regulation of glucose import GO:0046427 positive regulation of JAK-STAT cascade GO:0046628 positive regulation of insulin receptor signaling pathway GO:0046850 regulation of bone remodeling GO:0046881 positive regulation of follicle-stimulating hormone secretion GO:0048639 positive regulation of developmental growth GO:0050796 regulation of insulin secretion GO:0050810 regulation of steroid biosynthetic process GO:0050892 intestinal absorption GO:0050901 leukocyte tethering or rolling GO:0050999 regulation of nitric-oxide synthase activity GO:0051726 regulation of cell cycle GO:0051897 positive regulation of protein kinase B signaling GO:0060587 regulation of lipoprotein lipid oxidation GO:0060612 adipose tissue development GO:0061037 negative regulation of cartilage development GO:0070093 negative regulation of glucagon secretion GO:0071298 cellular response to L-ascorbic acid GO:0071300 cellular response to retinoic acid GO:0072604 interleukin-6 secretion GO:0072606 interleukin-8 secretion GO:0090335 regulation of brown fat cell differentiation GO:0098868 bone growth GO:1900015 regulation of cytokine production involved in inflammatory response GO:1900180 regulation of protein localization to nucleus GO:1900745 positive regulation of p38MAPK cascade GO:1904651 positive regulation of fat cell apoptotic process GO:1990051 activation of protein kinase C activity GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000486 negative regulation of glutamine transport GO:2000491 positive regulation of hepatic stellate cell activation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
