Human Gene LGALS1 (ENST00000215909.10_4) from GENCODE V47lift37
  Description: galectin 1 (from RefSeq NM_002305.4)
Gencode Transcript: ENST00000215909.10_4
Gencode Gene: ENSG00000100097.12_7
Transcript (Including UTRs)
   Position: hg19 chr22:38,071,643-38,075,809 Size: 4,167 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr22:38,071,710-38,075,756 Size: 4,047 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:38,071,643-38,075,809)mRNA (may differ from genome)Protein (135 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Human Cortex Gene ExpressionMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LEG1_HUMAN
DESCRIPTION: RecName: Full=Galectin-1; Short=Gal-1; AltName: Full=14 kDa laminin-binding protein; Short=HLBP14; AltName: Full=14 kDa lectin; AltName: Full=Beta-galactoside-binding lectin L-14-I; AltName: Full=Galaptin; AltName: Full=HBL; AltName: Full=HPL; AltName: Full=Lactose-binding lectin 1; AltName: Full=Lectin galactoside-binding soluble 1; AltName: Full=Putative MAPK-activating protein PM12; AltName: Full=S-Lac lectin 1;
FUNCTION: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.
SUBUNIT: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
SIMILARITY: Contains 1 galectin domain.
WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00116";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LGALS1
Diseases sorted by gene-association score: benign metastasizing leiomyoma (3), chronic monocytic leukemia (2), gestational trophoblastic neoplasm (2), connective tissue disease (2), echolalia (2), germ cell and embryonal cancer (1), hypertrichotic osteochondrodysplasia cantu type (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1531.90 RPKM in Cells - Cultured fibroblasts
Total median expression: 15258.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.9067-0.312 Picture PostScript Text
3' UTR -11.3053-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR015535 - Galectin_1
IPR001079 - Galectin_CRD

Pfam Domains:
PF00337 - Galactoside-binding lectin

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1GZW - X-ray 1W6M - X-ray 1W6N - X-ray 1W6O - X-ray 1W6P - X-ray 1W6Q - X-ray 2KM2 - NMR MuPIT 2ZKN - X-ray MuPIT 3OY8 - X-ray MuPIT 3OYW - X-ray MuPIT 3T2T - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P09382
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0030395 lactose binding
GO:0042803 protein homodimerization activity
GO:0043236 laminin binding

Biological Process:
GO:0002317 plasma cell differentiation
GO:0006915 apoptotic process
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010977 negative regulation of neuron projection development
GO:0031295 T cell costimulation
GO:0034120 positive regulation of erythrocyte aggregation
GO:0035900 response to isolation stress
GO:0042493 response to drug
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045445 myoblast differentiation
GO:0046598 positive regulation of viral entry into host cell
GO:0048678 response to axon injury
GO:0071333 cellular response to glucose stimulus
GO:0071407 cellular response to organic cyclic compound
GO:2001200 positive regulation of dendritic cell differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  CR456511 - Homo sapiens LGALS1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.LGALS1).
LF210353 - JP 2014500723-A/17856: Polycomb-Associated Non-Coding RNAs.
EU363770 - Homo sapiens beta-galactoside-binding lectin precursor (LGALS1) mRNA, complete cds.
AK312161 - Homo sapiens cDNA, FLJ92447, Homo sapiens lectin, galactoside-binding, soluble, 1 (galectin 1)(LGALS1), mRNA.
BC020675 - Homo sapiens lectin, galactoside-binding, soluble, 1, mRNA (cDNA clone MGC:22383 IMAGE:4722280), complete cds.
GQ891519 - Homo sapiens clone HEL-S-240 epididymis secretory sperm binding protein mRNA, complete cds.
AL832117 - Homo sapiens mRNA; cDNA DKFZp686E23103 (from clone DKFZp686E23103).
D28452 - Homo sapiens mRNA for beta-galactoside-binding protein 14kDa, 5'UTR region.
BC001693 - Homo sapiens lectin, galactoside-binding, soluble, 1, mRNA (cDNA clone MGC:1818 IMAGE:2967299), complete cds.
AB097036 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: PM12.
J04456 - Human 14 kd lectin mRNA, complete cds.
X15256 - Homo sapiens mRNA for 14kDa beta-galactoside-binding lectin.
E02651 - cDNA encoding human lectin.
X14829 - Human mRNA for beta-galactoside-binding lectin.
AB463095 - Synthetic construct DNA, clone: pF1KB8449, Homo sapiens LGALS1 gene for lectin, galactoside-binding, soluble, 1, without stop codon, in Flexi system.
AM392658 - Synthetic construct Homo sapiens clone IMAGE:100002542 for hypothetical protein (LGALS1 gene).
CU013398 - Homo sapiens LGALS1, mRNA (cDNA clone IMAGE:100000272), complete cds, without stop codon, in Gateway system.
BT006775 - Homo sapiens lectin, galactoside-binding, soluble, 1 (galectin 1) mRNA, complete cds.
DQ892263 - Synthetic construct clone IMAGE:100004893; FLH184687.01X; RZPDo839A10146D lectin, galactoside-binding, soluble, 1 (galectin 1) (LGALS1) gene, encodes complete protein.
DQ895465 - Synthetic construct Homo sapiens clone IMAGE:100009925; FLH184683.01L; RZPDo839A10145D lectin, galactoside-binding, soluble, 1 (galectin 1) (LGALS1) gene, encodes complete protein.
KJ891542 - Synthetic construct Homo sapiens clone ccsbBroadEn_00936 LGALS1 gene, encodes complete protein.
CU013110 - Homo sapiens LGALS1, mRNA (cDNA clone IMAGE:100000368), complete cds, with stop codon, in Gateway system.
LN607840 - Homo sapiens partial mRNA for lectin, galactoside-binding, soluble, 1 (LGALS1 gene).
LF337227 - JP 2014500723-A/144730: Polycomb-Associated Non-Coding RNAs.
LF337228 - JP 2014500723-A/144731: Polycomb-Associated Non-Coding RNAs.
LF337230 - JP 2014500723-A/144733: Polycomb-Associated Non-Coding RNAs.
LF337231 - JP 2014500723-A/144734: Polycomb-Associated Non-Coding RNAs.
S44881 - HL14=beta-galactoside binding protein [human, line CEM C7, mRNA Partial, 143 nt].
JD174400 - Sequence 155424 from Patent EP1572962.
LF337232 - JP 2014500723-A/144735: Polycomb-Associated Non-Coding RNAs.
MA445930 - JP 2018138019-A/17856: Polycomb-Associated Non-Coding RNAs.
MA572804 - JP 2018138019-A/144730: Polycomb-Associated Non-Coding RNAs.
MA572805 - JP 2018138019-A/144731: Polycomb-Associated Non-Coding RNAs.
MA572807 - JP 2018138019-A/144733: Polycomb-Associated Non-Coding RNAs.
MA572808 - JP 2018138019-A/144734: Polycomb-Associated Non-Coding RNAs.
MA572809 - JP 2018138019-A/144735: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P09382 (Reactome details) participates in the following event(s):

R-HSA-8952289 FAM20C phosphorylates FAM20C substrates
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5E8, ENST00000215909.1, ENST00000215909.2, ENST00000215909.3, ENST00000215909.4, ENST00000215909.5, ENST00000215909.6, ENST00000215909.7, ENST00000215909.8, ENST00000215909.9, LEG1_HUMAN, LGALS1 , NM_002305, P09382, Q9UDK5, uc317cnh.1, uc317cnh.2
UCSC ID: ENST00000215909.10_4
RefSeq Accession: NM_002305.4
Protein: P09382 (aka LEG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.