Human Gene LGALS7 (ENST00000378626.5_6) from GENCODE V47lift37

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Description: galectin 7 (from RefSeq NM_002307.4)
Gencode Transcript: ENST00000378626.5_6
Gencode Gene: ENSG00000205076.5_11
Transcript (Including UTRs)
Position: hg19 chr19:39,261,608-39,264,157 Size: 2,550 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr19:39,261,666-39,264,132 Size: 2,467 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:39,261,608-39,264,157)			mRNA (may differ from genome)		Protein (136 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: LEG7_HUMAN DESCRIPTION: RecName: Full=Galectin-7; Short=Gal-7; AltName: Full=HKL-14; AltName: Full=PI7; AltName: Full=p53-induced gene 1 protein; FUNCTION: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Secreted (Potential). Note=May be secreted by a non-classical secretory pathway. TISSUE SPECIFICITY: Mainly expressed in stratified squamous epithelium. INDUCTION: By p53/TP53. SIMILARITY: Contains 1 galectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-7; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00143";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: LGALS7 Diseases sorted by gene-association score: postencephalitic parkinson disease (2), infantile neuroaxonal dystrophy 1 (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D019833 Genistein C006780 bisphenol A C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester D015127 9,10-Dimethyl-1,2-benzanthracene D000643 Ammonium Chloride D001564 Benzo(a)pyrene D002251 Carbon Tetrachloride D002273 Carcinogens D003520 Cyclophosphamide more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 124.96 RPKM in Skin - Not Sun Exposed (Suprapubic) Total median expression: 279.43 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-8.00	25	-0.320	Picture	PostScript	Text
3' UTR	-18.60	58	-0.321	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR001079 - Galectin_CRD

Pfam Domains:
PF00337 - Galactoside-binding lectin

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1BKZ - X-ray MuPIT

2GAL - X-ray MuPIT

3GAL - X-ray MuPIT

3ZXE - X-ray MuPIT

3ZXF - X-ray MuPIT

4GAL - X-ray MuPIT

5GAL - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P47929


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0030246 carbohydrate binding Biological Process: GO:0006915 apoptotic process GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0005634 nucleus GO:0005737 cytoplasm GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BC042911 - Homo sapiens lectin, galactoside-binding, soluble, 7B, mRNA (cDNA clone IMAGE:5479169), partial cds. U06643 - Human keratinocyte lectin 14 (HKL-14) mRNA, complete cds. BC073743 - Homo sapiens lectin, galactoside-binding, soluble, 7B, mRNA (cDNA clone MGC:88745 IMAGE:5478866), complete cds. BC061588 - Homo sapiens lectin, galactoside-binding, soluble, 7B, mRNA (cDNA clone MGC:75149 IMAGE:6202380), complete cds. L07769 - Homo sapiens galectin-7 mRNA, complete cds. JD102661 - Sequence 83685 from Patent EP1572962. KJ900799 - Synthetic construct Homo sapiens clone ccsbBroadEn_10193 LGALS7B gene, encodes complete protein. AB590978 - Synthetic construct DNA, clone: pFN21AE1213, Homo sapiens LGALS7B gene for lectin, galactoside-binding, soluble, 7B, without stop codon, in Flexi system. CR456917 - Homo sapiens full open reading frame cDNA clone RZPDo834E0716D for gene LGALS7, lectin, galactoside-binding, soluble, 7 (galectin 7); complete cds, incl. stopcodon.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000378626.1, ENST00000378626.2, ENST00000378626.3, ENST00000378626.4, LEG7_HUMAN, LGALS7B, NM_002307, P47929, PIG1, Q6IB87, uc318okt.1, uc318okt.2 UCSC ID: ENST00000378626.5_6 RefSeq Accession: NM_002307.4 Protein: P47929 (aka LEG7_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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