ID:LGMN_HUMAN DESCRIPTION: RecName: Full=Legumain; EC=3.4.22.34; AltName: Full=Asparaginyl endopeptidase; AltName: Full=Protease, cysteine 1; Flags: Precursor; FUNCTION: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. CATALYTIC ACTIVITY: Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds. SUBCELLULAR LOCATION: Lysosome (By similarity). TISSUE SPECIFICITY: Ubiquitous. Particularly abundant in kidney, heart and placenta. PTM: Glycosylated. SIMILARITY: Belongs to the peptidase C13 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99538
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003014 renal system process GO:0006508 proteolysis GO:0006624 vacuolar protein processing GO:0007613 memory GO:0008284 positive regulation of cell proliferation GO:0008306 associative learning GO:0010447 response to acidic pH GO:0010629 negative regulation of gene expression GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0032801 receptor catabolic process GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0040015 negative regulation of multicellular organism growth GO:0042359 vitamin D metabolic process GO:0043524 negative regulation of neuron apoptotic process GO:0045931 positive regulation of mitotic cell cycle GO:0051603 proteolysis involved in cellular protein catabolic process GO:0071277 cellular response to calcium ion GO:0090026 positive regulation of monocyte chemotaxis GO:0097061 dendritic spine organization GO:0097202 activation of cysteine-type endopeptidase activity GO:0097264 self proteolysis GO:1900273 positive regulation of long-term synaptic potentiation GO:1901185 negative regulation of ERBB signaling pathway GO:1904646 cellular response to beta-amyloid GO:2001028 positive regulation of endothelial cell chemotaxis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
