ID:LHX1_HUMAN DESCRIPTION: RecName: Full=LIM/homeobox protein Lhx1; Short=LIM homeobox protein 1; AltName: Full=Homeobox protein Lim-1; Short=hLim-1; FUNCTION: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. SUBUNIT: Interacts with LDB1 via the tandem LIM domains (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines. DOMAIN: The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity). SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 2 LIM zinc-binding domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48742
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001702 gastrulation with mouth forming second GO:0001705 ectoderm formation GO:0001706 endoderm formation GO:0001822 kidney development GO:0001823 mesonephros development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007267 cell-cell signaling GO:0007275 multicellular organism development GO:0007389 pattern specification process GO:0007399 nervous system development GO:0008045 motor neuron axon guidance GO:0009653 anatomical structure morphogenesis GO:0009791 post-embryonic development GO:0009880 embryonic pattern specification GO:0009887 animal organ morphogenesis GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0009953 dorsal/ventral pattern formation GO:0010468 regulation of gene expression GO:0010842 retina layer formation GO:0021510 spinal cord development GO:0021517 ventral spinal cord development GO:0021527 spinal cord association neuron differentiation GO:0021537 telencephalon development GO:0021549 cerebellum development GO:0021702 cerebellar Purkinje cell differentiation GO:0021871 forebrain regionalization GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation GO:0030154 cell differentiation GO:0032525 somite rostral/caudal axis specification GO:0035502 metanephric part of ureteric bud development GO:0035846 oviduct epithelium development GO:0035847 uterine epithelium development GO:0035849 nephric duct elongation GO:0035852 horizontal cell localization GO:0040019 positive regulation of embryonic development GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0048646 anatomical structure formation involved in morphogenesis GO:0048703 embryonic viscerocranium morphogenesis GO:0048793 pronephros development GO:0060041 retina development in camera-type eye GO:0060059 embryonic retina morphogenesis in camera-type eye GO:0060065 uterus development GO:0060066 oviduct development GO:0060067 cervix development GO:0060068 vagina development GO:0060322 head development GO:0060429 epithelium development GO:0061205 paramesonephric duct development GO:0072001 renal system development GO:0072049 comma-shaped body morphogenesis GO:0072050 S-shaped body morphogenesis GO:0072077 renal vesicle morphogenesis GO:0072164 mesonephric tubule development GO:0072177 mesonephric duct development GO:0072178 nephric duct morphogenesis GO:0072224 metanephric glomerulus development GO:0072278 metanephric comma-shaped body morphogenesis GO:0072283 metanephric renal vesicle morphogenesis GO:0072284 metanephric S-shaped body morphogenesis GO:0090009 primitive streak formation GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis GO:0097379 dorsal spinal cord interneuron posterior axon guidance GO:0097477 lateral motor column neuron migration GO:2000543 positive regulation of gastrulation GO:2000744 positive regulation of anterior head development GO:2000768 positive regulation of nephron tubule epithelial cell differentiation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
