ID:LHX5_HUMAN DESCRIPTION: RecName: Full=LIM/homeobox protein Lhx5; Short=LIM homeobox protein 5; FUNCTION: Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed in fetal brain and in various regions of the adult central nervous system including the spinal cord, the thalamus, and the cerebellum. SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 2 LIM zinc-binding domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H2C1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007267 cell-cell signaling GO:0021527 spinal cord association neuron differentiation GO:0021549 cerebellum development GO:0021702 cerebellar Purkinje cell differentiation GO:0021766 hippocampus development GO:0021846 cell proliferation in forebrain GO:0021879 forebrain neuron differentiation GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation GO:0042127 regulation of cell proliferation GO:0045893 positive regulation of transcription, DNA-templated
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
