ID:LIF_HUMAN DESCRIPTION: RecName: Full=Leukemia inhibitory factor; Short=LIF; AltName: Full=Differentiation-stimulating factor; Short=D factor; AltName: Full=Melanoma-derived LPL inhibitor; Short=MLPLI; AltName: INN=Emfilermin; Flags: Precursor; FUNCTION: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. SUBCELLULAR LOCATION: Secreted. PHARMACEUTICAL: In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies (ART). SIMILARITY: Belongs to the LIF/OSM family. WEB RESOURCE: Name=Wikipedia; Note=Leukemia inhibitory factor entry; URL="http://en.wikipedia.org/wiki/Leukemia_inhibitory_factor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P15018
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001974 blood vessel remodeling GO:0006955 immune response GO:0007260 tyrosine phosphorylation of STAT protein GO:0007275 multicellular organism development GO:0007566 embryo implantation GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0010628 positive regulation of gene expression GO:0019221 cytokine-mediated signaling pathway GO:0019827 stem cell population maintenance GO:0030324 lung development GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043410 positive regulation of MAPK cascade GO:0045595 regulation of cell differentiation GO:0045651 positive regulation of macrophage differentiation GO:0045835 negative regulation of meiotic nuclear division GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046697 decidualization GO:0046888 negative regulation of hormone secretion GO:0048286 lung alveolus development GO:0048644 muscle organ morphogenesis GO:0048666 neuron development GO:0048711 positive regulation of astrocyte differentiation GO:0048861 leukemia inhibitory factor signaling pathway GO:0048863 stem cell differentiation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0060135 maternal process involved in female pregnancy GO:0060426 lung vasculature development GO:0060463 lung lobe morphogenesis GO:0060707 trophoblast giant cell differentiation GO:0060708 spongiotrophoblast differentiation GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation GO:1900182 positive regulation of protein localization to nucleus GO:1901676 positive regulation of histone H3-K27 acetylation GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
