Human Gene SYNE3 (ENST00000334258.9_6) from GENCODE V47lift37
Description: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. (from UniProt Q6ZMZ3) Gencode Transcript: ENST00000334258.9_6 Gencode Gene: ENSG00000176438.13_12 Transcript (Including UTRs) Position: hg19 chr14:95,883,831-95,942,173 Size: 58,343 Total Exon Count: 17 Strand: - Coding Region Position: hg19 chr14:95,884,163-95,942,158 Size: 57,996 Coding Exon Count: 17
ID:SYNE3_HUMAN DESCRIPTION: RecName: Full=Nesprin-3; AltName: Full=Nuclear envelope spectrin repeat protein 3; FUNCTION: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells. SUBUNIT: Component of LINC complexes composed of SUN domain- containing proteins SUN1 or SUN2 coupled to KASH domain-containing proteins (SYNE1, SYNE2 or SYNE3), also called nesprins. Interacts with PLEC (via actin-binding domain). Interacts with DST (By similarity). Interacts with SYNE1 via spectrin repeats. SUBCELLULAR LOCATION: Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Note=Localized uniformly throughout the nuclear envilope in aortic endothelial cells. Located at the rough reticulum endoplasmic (RER) in some cells. TISSUE SPECIFICITY: Expressed in aortic endothelial cells (at protein level). DOMAIN: The KASH domain is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. SIMILARITY: Belongs to the nesprin family. SIMILARITY: Contains 1 KASH domain. SIMILARITY: Contains 2 spectrin repeats. SEQUENCE CAUTION: Sequence=BAC05312.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD18582.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD62365.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZMZ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008092 cytoskeletal protein binding GO:0051015 actin filament binding
Biological Process: GO:0007010 cytoskeleton organization GO:0008360 regulation of cell shape GO:0090150 establishment of protein localization to membrane GO:0090286 cytoskeletal anchoring at nuclear membrane
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
