ID:LIPS_HUMAN DESCRIPTION: RecName: Full=Hormone-sensitive lipase; Short=HSL; EC=3.1.1.79; FUNCTION: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. CATALYTIC ACTIVITY: Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate. CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. CATALYTIC ACTIVITY: Monoacylglycerol + H(2)O = glycerol + a carboxylate. ENZYME REGULATION: Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. SUBUNIT: Interacts with PTRF in the adipocyte cytoplasm. SUBCELLULAR LOCATION: Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. PTM: Phosphorylation by AMPK may block translocation to lipid droplets (By similarity). SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/lipe/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q05469
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006468 protein phosphorylation GO:0006629 lipid metabolic process GO:0008152 metabolic process GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0016042 lipid catabolic process GO:0019433 triglyceride catabolic process GO:0042758 long-chain fatty acid catabolic process GO:0046340 diacylglycerol catabolic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
