Human Gene LLPH (ENST00000266604.7_7) from GENCODE V47lift37

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Description: LLP homolog, long-term synaptic facilitation factor (from RefSeq NM_032338.4)
Gencode Transcript: ENST00000266604.7_7
Gencode Gene: ENSG00000139233.7_10
Transcript (Including UTRs)
Position: hg19 chr12:66,510,335-66,524,530 Size: 14,196 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr12:66,517,620-66,522,886 Size: 5,267 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:66,510,335-66,524,530)			mRNA (may differ from genome)		Protein (129 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: LLPH_HUMAN DESCRIPTION: RecName: Full=Protein LLP homolog; AltName: Full=Protein LAPS18-like; SIMILARITY: Belongs to the learning-associated protein family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009505 4,4'-diaminodiphenylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001564 Benzo(a)pyrene D018038 Sodium Selenite D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.98 RPKM in Testis Total median expression: 128.10 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-10.70	53	-0.202	Picture	PostScript	Text
3' UTR	-2335.10	7285	-0.321	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR018784 - LAPS18-like

Pfam Domains:
PF10169 - Learning-associated protein

ModBase Predicted Comparative 3D Structure on Q9BRT6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0001099 basal RNA polymerase II transcription machinery binding GO:0003723 RNA binding Biological Process: GO:0060999 positive regulation of dendritic spine development GO:0097484 dendrite extension Cellular Component: GO:0005634 nucleus GO:0005694 chromosome GO:0005730 nucleolus

Descriptions from all associated GenBank mRNAs


	JD311763 - Sequence 292787 from Patent EP1572962. JD414793 - Sequence 395817 from Patent EP1572962. JD311762 - Sequence 292786 from Patent EP1572962. JD476722 - Sequence 457746 from Patent EP1572962. JD379646 - Sequence 360670 from Patent EP1572962. JD560687 - Sequence 541711 from Patent EP1572962. JD094107 - Sequence 75131 from Patent EP1572962. JD379645 - Sequence 360669 from Patent EP1572962. JD120549 - Sequence 101573 from Patent EP1572962. JD120550 - Sequence 101574 from Patent EP1572962. JD414791 - Sequence 395815 from Patent EP1572962. JD379644 - Sequence 360668 from Patent EP1572962. JD414790 - Sequence 395814 from Patent EP1572962. JD466377 - Sequence 447401 from Patent EP1572962. AK091568 - Homo sapiens cDNA FLJ34249 fis, clone FCBBF4000500. AX747065 - Sequence 590 from Patent EP1308459. AK057947 - Homo sapiens cDNA FLJ25218 fis, clone STM00381. BC070232 - Homo sapiens LLP homolog, long-term synaptic facilitation (Aplysia), mRNA (cDNA clone MGC:88214 IMAGE:4594274), complete cds. BC107780 - Homo sapiens LLP homolog, long-term synaptic facilitation (Aplysia), mRNA (cDNA clone MGC:104302 IMAGE:6698895), complete cds. JD123462 - Sequence 104486 from Patent EP1572962. JD190636 - Sequence 171660 from Patent EP1572962. JD270651 - Sequence 251675 from Patent EP1572962. JD293573 - Sequence 274597 from Patent EP1572962. JD092228 - Sequence 73252 from Patent EP1572962. JD183924 - Sequence 164948 from Patent EP1572962. JD066641 - Sequence 47665 from Patent EP1572962. JD029639 - Sequence 10663 from Patent EP1572962. JD309270 - Sequence 290294 from Patent EP1572962. JD361176 - Sequence 342200 from Patent EP1572962. JD447031 - Sequence 428055 from Patent EP1572962. JD472506 - Sequence 453530 from Patent EP1572962. JD145147 - Sequence 126171 from Patent EP1572962. JD111965 - Sequence 92989 from Patent EP1572962. JD313309 - Sequence 294333 from Patent EP1572962. BC006002 - Homo sapiens LLP homolog, long-term synaptic facilitation (Aplysia), mRNA (cDNA clone MGC:14817 IMAGE:4247279), complete cds. JD159699 - Sequence 140723 from Patent EP1572962. JD508436 - Sequence 489460 from Patent EP1572962. JD522479 - Sequence 503503 from Patent EP1572962. JD289011 - Sequence 270035 from Patent EP1572962. JD087948 - Sequence 68972 from Patent EP1572962. KJ894968 - Synthetic construct Homo sapiens clone ccsbBroadEn_04362 LLPH gene, encodes complete protein. AK301359 - Homo sapiens cDNA FLJ57212 complete cds, highly similar to Transmembrane BAX inhibitor motif-containing protein 4.

Other Names for This Gene


	Alternate Gene Symbols: C12orf31, cPERP-G , ENST00000266604.1, ENST00000266604.2, ENST00000266604.3, ENST00000266604.4, ENST00000266604.5, ENST00000266604.6, LLPH_HUMAN, NM_032338, Q3B766, Q9BRT6, uc317ihw.1, uc317ihw.2 UCSC ID: ENST00000266604.7_7 RefSeq Accession: NM_032338.4 Protein: Q9BRT6 (aka LLPH_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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